Correlation between admission hyperglycemia and postoperative pneumonia after hip fracture surgery: A propensity score-matched study DOI Creative Commons

Yuanchao Luo,

NI Xiao-min,

Wei Yao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 2, 2024

The association between admission hyperglycemia and postoperative pneumonia is unclear in hip fracture patients. We investigated the relationship after surgery. This retrospective study analyzed data from 1,267 geriatric patients admitted for fractures. Patients were categorized into normoglycemic (< 6.10 mmol/L) hyperglycemic (≥ groups based on blood glucose levels. Multivariable logistic regression propensity score matching (PSM) used to control potential confounding variables estimate adjusted odds ratios 95% confidence intervals (POP). also examined dose-dependent link likelihood of developing POP. Further analyses evaluated whether has differing impacts POP outcomes among without diabetes (NDM) versus those with (DM). Additionally, subgroup conducted assess influence other factors occurrence. had significantly higher rates compared patients, both before (13.2% vs. 4.8%) (10.1% 5.8%) PSM. Admission an independent risk factor (OR = 2.64, CI: 1.42–4.92, p 0.002). persisted PSM(OR 2.90, 1.35–3.86, 0.016). levels correlated a greater A dose–response was observed Non-diabetic group at than diabetic hyperglycemia. Finally, increased modulated influenced by ASA classification patient. surgery elderly. There occurrence POP, which more significant non-diabetic

Language: Английский

The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes DOI Open Access
T. G. HILL, David J. Hill

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4070 - 4070

Published: April 6, 2024

Islets of Langerhans are anatomically dispersed within the pancreas and exhibit regulatory coordination between islets in response to nutritional inflammatory stimuli. However, individual islets, there is also multi-faceted function beta-cells, beta-cells other endocrine vascular cell types. This mediated partly through circulatory feedback major secreted hormones, insulin glucagon, but by autocrine paracrine actions islet a range products, including somatostatin, urocortin 3, serotonin, glucagon-like peptide-1, acetylcholine, ghrelin. Their availability can be modulated pericyte-mediated regulation microvascular blood flow. Within islet, both progenitor cells ability trans-differentiate phenotypes alter mass adapt changed metabolic circumstances, regulated within-islet trophic environment. Optimal precariously balanced due high rate required synthesize secrete insulin, they susceptible oxidative endoplasmic reticular stress face demand. Resulting changes dynamics contribute emergence Types 1, 2 gestational diabetes.

Language: Английский

Citations

4
Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging DOI Creative Commons
Maima Matin, Tanuj Joshi, Dongdong Wang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 940 - 940

Published: Aug. 2, 2024

Ginger (

Language: Английский

Citations

4
TIM8 Deficiency in Yeast Induces Endoplasmic Reticulum Stress and Shortens the Chronological Lifespan DOI Creative Commons
Dong Tang,

Wenbin Guan,

Xiaodi Yang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 271 - 271

Published: Feb. 12, 2025

Yeast TIM8 was initially identified as a homolog of human TIMM8A/DDP1, which is associated with deafness-dystonia syndrome. Tim8p located in the mitochondrial intermembrane space and forms hetero-oligomeric complex Tim13p to facilitate protein transport through TIM22 translocation system. Previous research has indicated that not essential for yeast survival but does affect import Tim23p absence Tim8-Tim13 complex. on focused mainly its involvement pathway, precise biological function remains incompletely understood. In this study, we provide first report endoplasmic reticulum (ER) stress response chronological senescence. We found deletion leads both oxidative ER cells while increasing resistance inducer tunicamycin (TM), accompanied by an enhanced basic unfolded (UPR). More importantly, deficiency can lead shortened lifespan (CLS) replicative (RLS). Moreover, improving antioxidant capacity further increased TM tim8Δ strain. Importantly, evidence knockdown TIMM8A ARPE-19 retinal pigment epithelium also induce stress, suggesting potential gene conserved from budding higher eukaryotes. summary, these results suggest novel roles maintaining homeostasis CLS maintenance.

Language: Английский

Citations

0
Different formulations of semaglutide and oxidative stress in subjects with type 2 diabetes and MASLD: an open-label, real-life study DOI

Giovanni Petralli,

Alice Del Zoppo,

Chiara Rovera

et al.

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

Citations

0
The role of endoplasmic reticulum stress in type 2 diabetes mellitus mechanisms and impact on islet function DOI Creative Commons

Zhaxicao He,

Qian Liu, Yan Wang

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19192 - e19192

Published: March 28, 2025

Type 2 diabetes mellitus (T2DM) is a globally prevalent metabolic disorder characterized by insulin resistance and dysfunction of islet cells. Endoplasmic reticulum (ER) stress plays crucial role in the pathogenesis progression T2DM, especially function survival β-cells. β-cells are particularly sensitive to ER because they require substantial synthesis secretion energy. In early stages increased demand for exacerbates β-cell stress. Although unfolded protein response (UPR) can temporarily alleviate this stress, prolonged or excessive leads pancreatic cell apoptosis, resulting insufficient secretion. This review explores mechanisms its impact on We discuss how activates UPR signaling pathways regulate folding degradation, but when becomes excessive, these may contribute death. A deeper understanding impacts cells could lead development novel T2DM treatment strategies aimed at improving slowing disease progression.

Language: Английский

Citations

0
Insights into free radicals scavenging, α-Amylase inhibition, cytotoxic and antifibrotic activities unveiled by Peganum harmala extracts DOI Creative Commons
Nidal Jaradat, Mohammed Hawash, Majid Sharifi‐Rad

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 12, 2024

Peganum harmala L. is used in traditional medicine to treat several health ailments. Hence, the present work aimed investigate DPPH free radical scavenging, α-amylase, cytotoxic, and antifibrotic effects of hydrophilic extract fixed oil obtained from P. seeds. The were assessed for their abilities scavenge radicals inhibit α-amylase using reference bioassays. cytotoxicity was on cancer normal cell lines, including B16F1, Caco-2, COLO205, HeLa, Hep 3B G2, MCF-7, HEK-293 T cells. MTS assay evaluate capabilities utilizing human hepatic stellate (LX-2) line. plant has potent scavenging activity with an IC50 dose 79.43 ± 0.08 µg/ml. Besides, a poor anti-α-amylase effect compared antidiabetic drug Acarbose, doses 398 0.59 25.11 1.22 µg/ml, respectively. In addition, growth Hep3B, HepG2, CaCo2, HeK293t inhibited by 121.34 1.71, 268.3 0.75, 297.20 1.00, 155.60 1.14, 150.01 0.51, 308.35 0.53, 597.93 1.36, 5.38 0.99 at 1000 5-Fluorouracil reduced fibrosis cells 0.089%, while decreased number LX-2 5.81%. plant-fixed exhibits potential antioxidant properties. While showed limited effectiveness as agent demonstrated notable cytotoxic against various tested lines. Furthermore, this significantly reduces fibrotic These findings emphasize therapeutic these products managing disorders warrant further investigation into mechanisms action clinical applications.

Language: Английский

Citations

2
Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy DOI Creative Commons
Qirui Li,

Huiying Xu,

Rui-Ting Ma

et al.

Diabetes Therapy, Journal Year: 2024, Volume and Issue: 15(10), P. 2153 - 2182

Published: Aug. 21, 2024

Diabetes mellitus (DM) significantly impairs patients' quality of life, primarily because its complications, which are the leading cause mortality among individuals with disease. Autophagy has emerged as a key process closely associated DM, including complications such diabetic nephropathy (DN). DN is major complication contributing to chronic kidney disease and renal failure. The intricate connection between autophagy DN, highlights potential for new therapeutic targets. This review examines interplay these conditions, aiming uncover novel approaches treatment enhance our understanding their underlying pathophysiology. It also explores role in maintaining homeostasis involvement development progression DM DN. Furthermore, discusses natural compounds that may alleviate conditions by modulating autophagy.

Language: Английский

Citations

2
Pinitol Improves Diabetic Foot Ulcers in Streptozotocin-Induced Diabetes Rats Through Upregulation of Nrf2/HO-1 Signaling DOI Creative Commons

Jinsick Kim,

Min Young Go,

Chae Young Jeon

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 15 - 15

Published: Dec. 26, 2024

Diabetic foot ulcers represent a severe complication of diabetes, often resulting in amputation and high mortality rates. Currently, there are no treatments for diabetic other than antibiotics dressings. In this study, we evaluated the wound-healing effects an antidiabetic agent pinitol lipopolysaccharide (LPS)-damaged human dermal fibroblasts (HDFs) streptozotocin (STZ)-induced rat models with wound. Our findings indicated that enhanced cell migration, proliferation, wound healing by activating Nrf2, thereby mitigating oxidative stress inflammatory responses at site. Additionally, restored mitochondrial energy metabolism, decreased matrix metalloproteinase (MMP) activity, increased collagen deposition. Furthermore, facilitated angiogenesis, contributing to improved healing. Taken together, these suggest could be promising therapeutic treatment ulcers.

Language: Английский

Citations

1
Lipid on stroke in intracranial artery atherosclerotic stenosis: a mediation role of glucose DOI Creative Commons
Sheng Li, Yiqing Wang,

Xiangyi Zhu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 20, 2024

Objective Expanding on previous investigations, this study aims to elucidate the role of lipid metabolism disorders in development intracranial atherosclerotic stenosis (ICAS) and determination stroke risk. The primary objective is explore connections between parameters acute ischemic (AIS), while also examining potential mediating influence fasting glucose levels. Methods Retrospectively, we collected data from symptomatic ICAS patients at First Affiliated Hospital Soochow University, including their baseline information such as medical histories admission blood biochemical parameters. Stenotic conditions were evaluated using magnetic resonance imaging, computed tomography angiography, or digital subtraction angiography. associations AIS risks investigated via multivariate logistic regression analysis. Results A total 1103 with recruited, among whom 441 (40.0%) suffered new events during hospitalization. After adjusting for confounding factors, RCS curves exhibited a dose-response relationship atherogenic index plasma (AIP), cholesterol (TC), low-density lipoprotein (LDL-C), AIS. Further analysis revealed significant these Furthermore, mediation indicated that (FBG) acted mediator association (AIP, TC, TG) Conclusion Higher patients, particularly AIP, TG, associated an increased Additionally, FBG may mediate risk highlighting need further exploration underlying mechanisms.

Language: Английский

Citations

0
Reactive oxygen species-responsive prodrugs DOI
Sébastien Clément, Jean‐Yves Winum

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 53 - 71

Published: Oct. 4, 2024

Language: Английский

Citations

0