Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 27, 2024
Abstract
Antibacterial
photodynamic
therapy
(aPDT)
and
antibacterial
sonodynamic
(aSDT)
utilize
sensitizers
(photosensitizers/sonosensitizers)
to
produce
reactive
oxygen
species
(ROS)
for
treatment
under
the
stimulation
of
light/ultrasound,
which
have
characteristics
broad‐spectrum
properties,
low
drug‐resistance,
effective
targeting
infected
tissues.
Nanomaterials
in
aPDT/aSDT
are
primarily
used
as
nano‐sensitizers
or
nano‐carriers
sensitizers.
They
enhance
stability
permeability
sensitizers,
improve
strengthen
photodynamic/sonodynamic
properties
(modification
absorption
efficiency
light/ultrasonic
response
stress
by
modulation
nanoparticle
shape,
size,
structure).
Also,
they
modifiability
(controlling
release
rate
time
sensitizer
needed
optimize
therapeutic
effect),
programmability
multifunctionality
(flexible
application
nanotechnology
designing
with
multiple
functions,
such
drug
delivery,
targeted
therapy,
monitoring),
expand
possibilities
combination
therapies
(the
can
be
loaded
other
agents,
enabling
therapies).
expected
further
promote
development
achieve
improved
effects.
This
review
summarizes
progress
nanomaterials
recent
years
based
on
current
strategies
provide
a
theoretical
reference
aPDT/aSDT.
Small,
Journal Year:
2021,
Volume and Issue:
17(12)
Published: Feb. 12, 2021
Abstract
Nanotechnology
has
provided
great
opportunities
for
managing
neoplastic
conditions
at
various
levels,
from
preventive
and
diagnostic
to
therapeutic
fields.
However,
when
it
comes
clinical
application,
nanoparticles
(NPs)
have
some
limitations
in
terms
of
biological
stability,
poor
targeting,
rapid
clearance
the
body.
Therefore,
biomimetic
approaches,
utilizing
immune
cell
membranes,
are
proposed
solve
these
issues.
For
example,
macrophage
or
neutrophil
membrane
coated
NPs
developed
with
ability
interact
tumor
tissue
suppress
cancer
progression
metastasis.
The
functionality
particles
largely
depends
on
surface
proteins
cells
their
preserved
function
during
extraction
coating
process
NPs.
Proteins
outer
can
render
a
wide
range
activities
NPs,
including
prolonged
blood
circulation,
remarkable
competency
recognizing
antigens
enhanced
better
cellular
interactions,
gradual
drug
release,
reduced
toxicity
vivo.
In
this
review,
nano‐based
systems
cells‐derived
membranous
layers,
detailed
production
process,
applicability
treatment
discussed.
addition,
future
perspectives
challenges
translation
also
presented.
Nano-Micro Letters,
Journal Year:
2020,
Volume and Issue:
12(1)
Published: July 5, 2020
Abstract
Although
notable
progress
has
been
made
on
novel
cancer
treatments,
the
overall
survival
rate
and
therapeutic
effects
are
still
unsatisfactory
for
patients.
Chemoimmunotherapy,
combining
chemotherapeutics
immunotherapeutic
drugs,
emerged
as
a
promising
approach
treatment,
with
advantages
of
cooperating
two
kinds
treatment
mechanism,
reducing
dosage
drug
enhancing
effect.
Moreover,
nano-based
delivery
system
(NDDS)
was
applied
to
encapsulate
chemotherapeutic
agents
exhibited
outstanding
properties
such
targeted
delivery,
tumor
microenvironment
response
site-specific
release.
Several
nanocarriers
have
approved
in
clinical
chemotherapy
showed
significant
improvement
efficiency
compared
traditional
formulations,
liposomes
(Doxil
®
,
Lipusu
),
nanoparticles
(Abraxane
)
micelles
(Genexol-PM
).
The
applications
NDDS
chemoimmunotherapy
would
be
powerful
strategy
future
which
could
greatly
enhance
efficacy,
reduce
side
optimize
outcomes
Herein,
current
approaches
immunotherapy
were
discussed,
recent
advances
further
reviewed.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: June 7, 2021
Abstract
Over
the
past
decades,
great
interest
has
been
given
to
biomimetic
nanoparticles
(BNPs)
since
rise
of
targeted
drug
delivery
systems
and
nanotechnology.
Biological
vectors
including
cell
membranes,
extracellular
vesicles
(EVs),
viruses
are
considered
promising
candidates
for
owing
their
biocompatibility
biodegradability.
BNPs,
integration
biological
functional
agents,
anticipated
load
cargos
or
camouflage
synthetic
achieve
delivery.
Despite
excellent
intrinsic
properties,
natural
deliberately
modified
endow
multiple
functions
such
as
good
permeability,
improved
loading
capability,
high
specificity.
Through
structural
modification
transformation
vectors,
they
pervasively
utilized
more
effective
vehicles
that
can
deliver
contrast
chemotherapy
drugs,
nucleic
acids,
genes
target
sites
refractory
disease
therapy.
This
review
summarizes
recent
advances
in
based
on
EVs,
viruses,
highlighting
potential
applications
BNPs
fields
biomedical
imaging
therapy
industry,
well
discussing
possibility
clinical
translation
exploitation
trend
these
BNPs.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(6)
Published: May 23, 2022
Immunotherapy
is
used
to
regulate
systemic
hyperactivation
or
hypoactivation
treat
various
diseases.
Biomaterial-based
immunotherapy
systems
can
improve
therapeutic
effects
through
targeted
drug
delivery,
immunoengineering,
etc.
However,
the
immunomodulatory
of
biomaterials
themselves
cannot
be
neglected.
In
this
review,
we
outline
with
functions
discovered
in
recent
years
and
their
applications
disease
treatment.
These
inflammation,
tumors,
autoimmune
diseases
by
regulating
immune
cell
function,
exerting
enzyme-like
activity,
neutralizing
cytokines,
The
prospects
challenges
biomaterial-based
modulation
are
also
discussed.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 945 - 985
Published: Nov. 23, 2020
Cell
primitive-based
functional
materials
that
combine
the
advantages
of
natural
substances
and
nanotechnology
have
emerged
as
attractive
therapeutic
agents
for
cancer
therapy.
primitives
are
characterized
by
distinctive
biological
functions,
such
long-term
circulation,
tumor
specific
targeting,
immune
modulation
etc.
Moreover,
synthetic
nanomaterials
featuring
unique
physical/chemical
properties
been
widely
used
effective
drug
delivery
vehicles
or
anticancer
to
treat
cancer.
The
combination
these
two
kinds
will
catalyze
generation
innovative
biomaterials
with
multiple
high
biocompatibility
negligible
immunogenicity
precise
In
this
review,
we
summarize
most
recent
advances
in
development
cell
Different
primitives,
including
bacteria,
phages,
cells,
membranes,
other
bioactive
introduced
their
strategies
combining
materials,
especially
nanoparticulate
systems,
construction
function-enhanced
also
summarized.
Furthermore,
foreseeable
challenges
future
perspectives
included
research
direction
field.
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(22), P. 4459 - 4474
Published: Jan. 1, 2021
In
the
presented
perspective,
synthetic
method,
characterization,
and
research
progress
in
tumor
therapy
based
on
CMMs
have
been
summarized.
Also
prospects
challenges
of
utilizing
for
discussed.
