Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114502 - 114502
Published: Aug. 23, 2022
Language: Английский
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 22 - 36
Published: Sept. 19, 2022
Language: Английский
Citations
143
Small Methods, Journal Year: 2022, Volume and Issue: 6(8)
Published: June 29, 2022
Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.
Language: Английский
Citations
139
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(8), P. 3233 - 3254
Published: Feb. 28, 2022
Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of had positive effects on clinical treatment. However, is still restricted heterogeneity, immune cell disability, tumor immunosuppressive microenvironment systemic toxicity. Cell membrane-coated nanoparticles (CMCNs) inherit abundant source cell-relevant functions, including "self" markers, cross-talking biological targeting, homing to specific regions. These enable them possess preferred characteristics, better compatibility, weak immunogenicity, escaping, a prolonged circulation, targeting. Therefore, they are applied precisely deliver drugs promote effect immunotherapy. In review, we summarize latest researches biomimetic CMCNs for immunotherapy, outline existing therapies, explore unique functions molecular mechanisms various nanoparticles, analyze challenges which face in translation.
Language: Английский
Citations
134
Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 237, P. 109855 - 109855
Published: April 4, 2022
Language: Английский
Citations
118
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(8), P. 2096 - 2113
Published: Feb. 2, 2021
Cell membranes have recently emerged as a new source of materials for molecular delivery systems. been extruded or sonicated to make nanoscale vesicles. Unlike synthetic lipid polymeric nanoparticles, cell membrane-derived vesicles unique multicomponent feature, comprising lipids, proteins, and carbohydrates. Because contain the intrinsic functionalities signaling networks their parent cells, they can overcome various obstacles encountered
Language: Английский
Citations
116
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 194, P. 114724 - 114724
Published: Feb. 4, 2023
The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after administration, doses fail to reach effective intratumoral concentrations, while high significant tumor inhibition effects may also drive the death healthy cells, endangering patients. Therefore, strategies based on drug delivery systems (DDSs) for avoiding toxicity have been designed. Due their ability protect drugs from early elimination and control release, DDSs can foster exposure therapeutics extending circulation time steadily releasing into sites. However, approval tailored clinical minimal as safety in vivo activity still need be ameliorated manipulating physicochemical characteristics. During last few years, several described improve safety, stability, fine-tune pharmaceuticals release kinetics. Herein, we reviewed main DDSs, namely polymeric conjugates, nano microparticles, hydrogels, microneedles, explored long-acting treatments, highlighting recently proposed modifications potential advantages different therapies. Additionally, important limitations therapies future technology directions were covered.
Language: Английский
Citations
100
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 182, P. 114107 - 114107
Published: Jan. 4, 2022
Language: Английский
Citations
90
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: March 18, 2022
With the gradual demographic shift toward an aging and obese society, increasing number of patients are suffering from bone cartilage injuries. However, conventional therapies hindered by defects materials, failing to adequately stimulate necessary cellular response promote sufficient regeneration, remodeling osseointegration. In recent years, rapid development nanomedicine has initiated a revolution in orthopedics, especially tissue engineering regenerative medicine, due their capacity effectively responses on nanoscale with enhanced drug loading efficiency, targeted capability, increased mechanical properties improved uptake rate, resulting therapeutic effect. Therefore, comprehensive review advancements for diseases is timely beneficial. This firstly summarized wide range existing nanotechnology applications medical field. The progressive nano delivery systems nanomedicine, including nanoparticles biomimetic techniques, which lacking current literature, further described. More importantly, we also highlighted research repair using latest preclinical clinical examples, discussed directions nano-therapies future practice.
Language: Английский
Citations
88
Small Methods, Journal Year: 2022, Volume and Issue: 6(11)
Published: Oct. 6, 2022
Abstract Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following kinetics. Compared natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, magnetic, fluorescent, electrical properties nanomaterials, making them promising replacements for enzymes in industrial, biological, medical fields. On account rapid development recently, their application potentials regeneration medicine are gradually being explored. To highlight achievements field, this review summarizes catalytic mechanism four types representative nanozymes. Then, strategies improve biocompatibility discussed. covers recent advances tissue including wound healing, nerve defect repair, bone regeneration, cardiovascular disease treatment. In addition, challenges prospects nanozyme researches summarized.
Language: Английский
Citations
86
Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)
Published: Nov. 2, 2022
Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.
Language: Английский
Citations
84