Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 616 - 616

Published: Jan. 18, 2022

Multidrug resistance is a leading concern in public health. It describes complex phenotype whose predominant feature to wide range of structurally unrelated cytotoxic compounds, many which are anticancer agents. may be also related antimicrobial drugs, and known one the most serious global health threats this century. Indeed, phenomenon has increased both mortality morbidity as consequence treatment failures its incidence healthcare costs. The large amounts antibiotics used human therapies, well for farm animals even fishes aquaculture, resulted selection pathogenic bacteria resistant multiple drugs. not negligible that ongoing COVID-19 pandemic further contribute resistance. In paper, multidrug underlined, focusing on therapeutic options overcome these obstacles drug treatments. Lastly, some recent studies nanodrug delivery systems have been reviewed since they represent significant approach overcoming

Language: Английский

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Anticancer drug resistance: An update and perspective

Drug Resistance Updates, Journal Year: 2021, Volume and Issue: 59, P. 100796 - 100796

Published: Dec. 1, 2021

Driver mutations promote initiation and progression of cancer. Pharmacological treatment can inhibit the action mutant protein; however, drug resistance almost invariably emerges. Multiple studies revealed that cancer is based upon a plethora distinct mechanisms. Drug occur in same protein or different proteins; as well pathway parallel pathways, bypassing intercepted signaling. The dilemma clinical oncologist facing not all genomic alterations tumor microenvironment facilitate cell proliferation are known, neither likely to metastasis. For example, common KRas

Language: Английский

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Hypoxia as a driver of resistance to immunotherapy

Drug Resistance Updates, Journal Year: 2021, Volume and Issue: 59, P. 100787 - 100787

Published: Nov. 18, 2021

Language: Английский

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Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114770 - 114770

Published: March 7, 2023

Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains huge challenge due multiple barriers that significantly the ultimate therapeutic efficacy drugs. Recent advances in nanocarrier technology offer promising opportunity overcome these by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, targeted loaded eyes. This review primarily provides an overview progress contemporary applications nanocarriers, mainly polymer- lipid-based treating various eye highlighting their value achieving delivery. Additionally, covers administration routes, as well prospective future developments challenges field nanocarriers for diseases.

Language: Английский

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Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 31, 2022

Abstract The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable revolutionizing health care by improving efficacy, bioavailability, drug targeting, safety. NPs are intriguing when considering medical applications because their essential unique qualities, including a significantly higher surface to mass ratio, quantum properties, the potential adsorb transport drugs other compounds. However, must overcome or navigate several biological barriers human body successfully deliver at precise locations. Engineering carrier biointerface can help main optimize delivery in more personalized manner. This review discusses significant heterogeneous how engineering promote carriers prevail over hurdles manner, thus ushering era Precision Medicine. We also summarize nanomedicines' current advantages disadvantages administration, from natural/synthetic sources clinical applications. Additionally, we explore innovative NP designs used both non-personalized customized as well they attain therapeutic strategy.

Language: Английский

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Advances of medical nanorobots for future cancer treatments

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: July 14, 2023

Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.

Language: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(11), P. 762 - 779

Published: Sept. 15, 2023

Language: Английский

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Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 63, P. 100844 - 100844

Published: May 2, 2022

Selenium is an essential trace element that crucial for cellular antioxidant defense against reactive oxygen species (ROS). Recently, many selenium-containing compounds have exhibited a wide spectrum of biological activities make them promising scaffolds in Medicinal Chemistry, and, particular, the search novel with anticancer activity. Similarly, certain tellurium-containing also substantial activities. Here we provide overview seleno- and tellurocompounds including chemopreventive activity, or pro-oxidant modulation inflammatory processes, induction apoptosis, autophagy, inhibition multidrug efflux pumps such as P-gp, cancer metastasis, selective targeting tumors enhancement cytotoxic activity chemotherapeutic drugs, well overcoming tumor drug resistance. A review chemistry most relevant resistant cancers presented, paying attention to synthesis these preparation bioactive selenium tellurium nanoparticles. Based on data, use approach development strategies can drive forward therapies adjuvants current drug-resistant cancers.

Language: Английский

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Flower-like Nanozyme with Highly Porous Carbon Matrix Induces Robust Oxidative Storm against Drug-Resistant Cancer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(7), P. 6731 - 6744

Published: March 22, 2023

Reactive oxygen species (ROS) generators are sparking breakthroughs in sensitization and treatment of therapy-resistant tumors, yet the efficacy is drastically compromised by limited substrate concentrations, short lifetimes free radicals, restricted oxidative damage. Herein, a flower-like nanozyme with highly permeable leaflets accommodating catalytic metal sites was developed to address challenges boosting product accessibility. In formation zeolite imidazole framework, cobalt ions promoted polymerization deposition polydopamine. The polymers acted as stiffener for preventing framework collapse maneuvering pore reopening during carbonization. single-atom/cluster porous matrix generated peroxidase/oxidase-like activities high efficiency (Kcat/Km) up 6 orders magnitude greater than that conventional nano-/biozymes. Thereby, robust ROS storm induced selective catalysis led rapid accumulation damage failure antioxidant antiapoptotic defense synchronization drug-resistant cancer cells. By synergy redox homeostasis disrupter co-delivered, significantly antitumor realized vivo. This work offers route kinetically favorable advancing tumors.

Language: Английский

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