Journal of Macromolecular Science Part A, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: Feb. 27, 2025
Language: Английский
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522
Published: Dec. 21, 2022
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.
Language: Английский
Citations
259
Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3023 - 3023
Published: July 26, 2022
Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.
Language: Английский
Citations
206
Marine Drugs, Journal Year: 2023, Volume and Issue: 21(3), P. 189 - 189
Published: March 18, 2023
Today, with the salient advancements of modern and smart technologies related to tissue engineering regenerative medicine (TE-RM), use sustainable biodegradable materials biocompatibility cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer can be obtained from brown seaweed develop wide variety composites for TE, drug delivery, wound healing, cancer therapy. This renewable biomaterial displays several fascinating properties such high biocompatibility, low toxicity, cost-effectiveness, mild gelation by inserting divalent cations (e.g., Ca2+). In this context, challenges still exist in relation solubility viscosity high-molecular weight alginate, density intra- inter-molecular hydrogen bonding, polyelectrolyte nature aqueous solution, lack suitable organic solvents. Herein, TE-RM applications alginate-based are deliberated, focusing on current trends, important challenges, future prospects.
Language: Английский
Citations
107
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 230, P. 123231 - 123231
Published: Jan. 11, 2023
Language: Английский
Citations
69
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1147 - 1147
Published: Jan. 20, 2022
The articular cartilage has insufficient intrinsic healing abilities, and injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials for repair regeneration, allowing the delivery of cells therapeutic drugs gene sequences. In light heterogeneity findings reporting benefits using alginate a better understanding alginate-based systems is needed in order improve approaches aiming enhance regeneration with this compound. This review provides an in-depth evaluation literature, focusing on manipulation as tool support processes involved demonstrate how such material, used direct compound or combined cell therapy scaffold-guided transfer procedures, may assist optimal manner future applications patients.
Language: Английский
Citations
68
Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(6)
Published: Nov. 28, 2022
Marine organisms provide novel and broad sources for the preparations applications of biomaterials. Since urgent requirement bio‐hydrogels to mimic tissue extracellular matrix (ECM), natural biomacromolecule hydrogels derived from marine have received increasing attention. Benefiting their outstanding bioactivity biocompatibility, many attempts been made reconstruct ECM components by applying marine‐derived hydrogels. Moreover, successfully applied in biomedicine means microfluidics, electrospray, bioprinting. In this review, classification characteristics are summarized. particular, role development biomaterials is also introduced. Then, recent advances bio‐fabrication strategies various hydrogel materials focused upon. Besides, influences types on functions biomedical discussed depth. Finally, critical reflections limitations future presented.
Language: Английский
Citations
41
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(19), P. 21800 - 21813
Published: May 9, 2022
In this study, we developed three-dimensional (3D) printed annular ring-like scaffolds of hydrogel (gelatin-alginate) constructs encapsulated with a mixture human cardiac AC16 cardiomyocytes (CMs), fibroblasts (CFs), and microvascular endothelial cells (ECs) as organoid models in preparation for investigating the role microgravity cardiovascular disease initiation development. We studied mechanical properties acellular confirmed their cell compatibility well heterocellular coupling tissue engineering. Rheological analysis performed on showed to be elastogenic elastic modulus within range native
Language: Английский
Citations
39
Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 321, P. 103030 - 103030
Published: Oct. 20, 2023
The impairment of articular cartilage due to traumatic incidents or osteoarthritis has posed significant challenges for healthcare practitioners, researchers, and individuals suffering from these conditions. Due the absence an approved treatment strategy complete restoration defects their native state, tissue condition often deteriorates over time, leading osteoarthritic (OA). However, recent advancements in field regenerative medicine have unveiled promising prospects through utilization injectable hydrogels. This versatile class biomaterials, characterized by ability emulate characteristics cartilage, offers distinct advantage minimally invasive administration directly site damage. These hydrogels can also serve as ideal delivery vehicles a diverse range bioactive agents, including growth factors, anti-inflammatory drugs, steroids, cells. controlled release such biologically active molecules hydrogel scaffolds accelerate healing, stimulate chondrogenesis, modulate inflammatory microenvironment halt progression. present review aims describe methods used design hydrogels, expound upon applications molecules, provide update on advances leveraging systems foster regeneration.
Language: Английский
Citations
39
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 230, P. 123246 - 123246
Published: Jan. 14, 2023
Language: Английский
Citations
31
Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 266, P. 111018 - 111018
Published: Sept. 21, 2023
Language: Английский
Citations
30