Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application DOI Creative Commons
Nafiseh Baheiraei, Mehdi Razavi, Ramin Ghahremanzadeh

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of death worldwide and a major contributor to disability. Cardiac tissue engineering is promising approach for preventing functional damage or improving cardiac function after MI. We aimed introduce novel electroactive patch based on reduced graphene oxide-coated alginate scaffolds due behavior biomaterials regulate cell proliferation, biocompatibility, signal transition.The fabrication patches (ALG) coated with different concentrations oxide (rGO) using sodium hydrosulfite described here. The prepared were thoroughly tested their physicochemical properties cytocompatibility. ALG-rGO also antimicrobial antioxidant properties. Subcutaneous implantation in mice was used evaluate scaffolds' ability induce angiogenesis.The Young modulus increased by increasing rGO concentration from 92 ± 4.51 kPa ALG 431 4.89 ALG-rGO-4 (ALG 0.3% w/v rGO). tensile strength trended similarly. electrical conductivity calculated semi-conductive range (~ 10-4 S/m). Furthermore, when compared scaffolds, human umbilical vein endothelial cells (HUVECs) cultured demonstrated improved viability adhesion. Upregulation VEGFR2 expression at both mRNA protein levels confirmed that coating significantly boosted angiogenic capability against HUVECs. OD620 assay FE-SEM observation antibacterial Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes. showed samples possessed activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging UV-vis spectroscopy. Histological evaluations enhanced vascularization subcutaneous implantation.Our findings suggest scaffold accelerating repair damaged heart tissue.

Language: Английский

Recent advances in cellulose- and alginate-based hydrogels for water and wastewater treatment: A review DOI
Sabarish Radoor,

Jasila Karayil,

Aswathy Jayakumar

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121339 - 121339

Published: Sept. 1, 2023

Language: Английский

Citations

98
Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy DOI

Qimeng Wu,

Yang Hu, Bing Yu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 19 - 43

Published: Aug. 24, 2023

Language: Английский

Citations

55
Nano-hydroxyapatite (nHAp) scaffolds for bone regeneration: Preparation, characterization and biological applications DOI
Fouad Damiri, Ahmed Fatimi, Adina Magdalena Musuc

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105601 - 105601

Published: March 18, 2024

Language: Английский

Citations

34
Alginate-Based Encapsulation Fabrication Technique for Drug Delivery: An Updated Review of Particle Type, Formulation Technique, Pharmaceutical Ingredient, and Targeted Delivery System DOI Creative Commons
Joanne Lai, Abul Kalam Azad, Wan Mohd Azizi Wan Sulaiman

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 370 - 370

Published: March 6, 2024

Alginate is a natural biopolymer widely studied for pharmaceutical applications due to its biocompatibility, low toxicity, and mild gelation abilities. This review summarizes recent advances in alginate-based encapsulation systems targeted drug delivery. formulations like microparticles, nanoparticles, microgels, composites fabricated by methods including ionic gelation, emulsification, spray drying, freeze drying enable tailored loading, enhanced stability, sustained release kinetics. microspheres prepared or provide gastric protection colon-targeted of orally delivered drugs. nanoparticles exhibit cellular uptake tumor-targeting capabilities through the permeation retention effect. Crosslinked alginate microgels allow high loading controlled profiles. Composite gels with cellulose, chitosan, inorganic nanomaterials display improved mechanical properties, mucoadhesion, tunable Alginate-based wound dressings containing antimicrobial promote healing burns chronic wounds topical Although well-established as excipient, more extensive vivo testing needed assess clinical safety efficacy emerging prior human trials. Future opportunities include engineered combining stimuli-responsiveness, active targeting, diagnostic capabilities. In summary, this discusses techniques oral, transdermal, intravenous delivery, an emphasis on approaches enabling therapeutic outcomes.

Language: Английский

Citations

30
3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review DOI
Arnaud Kamdem Tamo, Lesly Dasilva Wandji Djouonkep,

Naomie Beolle Songwe Selabi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132123 - 132123

Published: May 17, 2024

Language: Английский

Citations

18
Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care DOI Open Access

A. S. Alberts,

Elena-Theodora Moldoveanu,

Adelina-Gabriela Niculescu

et al.

Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(3), P. 133 - 133

Published: March 13, 2025

Severe skin injuries such as burns and chronic wounds are a subject of interest in the medical field, they require much attention. These types susceptible to serious complications, which can worsen health patients reduce their quality life. Hydrogels have emerged innovative wound dressings for treating acute wounds, including burns, diabetic foot ulcers, venous leg pressure ulcers. polymeric networks provide moist environment, promote cellular migration, offer antimicrobial properties, being recognized superior conventional dressings. This review aims explore recent advancements hydrogel-based dressings, emphasizing state-of-the-art technologies used this purpose trend achieving personalized therapeutic approaches. Despite promising vitro vivo findings described review, further clinical validation large-scale manufacturing optimizations required widespread adoption.

Language: Английский

Citations

3
4D printing in skin tissue engineering: A revolutionary approach to enhance wound healing and combat infections DOI Creative Commons
Laila A. Damiati, Samar A. Alsudir,

Rean Y. Mohammed

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: 45, P. e00386 - e00386

Published: Jan. 5, 2025

Language: Английский

Citations

2
Bone Regeneration: A Review of Current Treatment Strategies DOI Open Access

Ralphenia D. Pace,

Simone Molinari,

Elisa Mazzoni

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1838 - 1838

Published: March 8, 2025

Bone regeneration has emerged as a critical research and clinical advancement field, fueled by the growing demand for effective treatments in orthopedics oncology. Over past two decades, significant progress biomaterials surgical techniques led to development of novel solutions treating bone defects, surpassing use traditional autologous grafts. This review aims assess latest approaches regeneration, including autologous, allogenic, xenogenic grafts, naturally derived biomaterials, innovative synthetic substitutes such bioceramics, bioactive glasses, metals, polymers, composite materials, other specialized applications. A comprehensive literature search was conducted on PubMed, focusing studies published between 2019 2024, meta-analyses, reviews, systematic reviews. The evaluated range strategies, examining outcomes, materials used, techniques, effectiveness various defects. identified numerous studies, with inclusion criteria focused those exploring strategies. These provided valuable insights into biological outcomes different graft types. Results indicated that while advancements show promising potential, challenges remain optimizing therapeutic strategies across diverse patient populations settings. findings emphasize need an integrated approach combines scientific research, practice, technological innovation improve therapies. Further is required establish standardized protocols determine optimal application enhance quality care.

Language: Английский

Citations

2
A sustainable alginate-based multifunctional porous material with integrated thermal barrier and reversible fire warning for enhanced building protection DOI
Md Hasib Mia, Yuhang Wan, Qing Jiang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123563 - 123563

Published: March 1, 2025

Language: Английский

Citations

2
Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches DOI Creative Commons
Jaewoo Choi, Eun Ji Lee, Woong Bi Jang

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(10), P. 497 - 497

Published: Oct. 8, 2023

Within the human body, intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen maintaining homeostasis. Bioprinting is an innovative technology with potential to revolutionize this field by constructing complex multicellular structures. This technique offers advantage depositing individual cells, growth factors, biochemical signals, thereby facilitating functional vessels. Despite challenges fabricating vascularized constructs, bioprinting has emerged as advance organ engineering. The continuous evolution biomaterial knowledge provides avenue overcome hurdles associated tissue fabrication. article overview biofabrication process used create vascular constructs. It delves into various techniques engineering, including extrusion-, droplet-, laser-based methods. Integrating these prospect crafting artificial remarkable precision functionality. Therefore, impact engineering significant. With technological advances, it holds promise revolutionizing transplantation, regenerative medicine. By mimicking natural complexity vessels, brings us one step closer organs vasculature, ushering new era medical advancement.

Language: Английский

Citations

24