Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394

Published: June 11, 2024

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.

Language: Английский

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Inspired by nature: Bioinspired and biomimetic photocatalysts for biomedical applications

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

The field of photocatalysis has witnessed a significant advancement in the development bioinspired and biomimetic photocatalysts for various biomedical applications, including drug delivery, tissue engineering, cancer therapy, bioimaging. Nature evolved efficient light-harvesting systems energy conversion mechanisms, which serve as benchmark researchers. However, reproducing such complexity harnessing it applications is daunting task. It requires comprehensive understanding underlying biological processes ability to replicate them synthetically. By utilizing light energy, these can trigger specific chemical reactions, leading targeted release, enhanced regeneration, precise imaging structures. In this context, addressing stability, long-term performance, scalability, cost-effectiveness materials crucial their widespread implementation applications. While challenges stability persist, advantages delivery personalized medicine make fascinating area research. purpose review provide analysis evaluation existing research, highlighting advancements, current challenges, advantages, limitations, future prospects biomedicine.

Language: Английский

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Liposomal Formulations: A Recent Update

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 36 - 36

Published: Dec. 30, 2024

Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative loading release mechanisms highlighted this review of next-generation liposomal formulations. Due to poor kinetics capacity, conventional liposomes limited clinical use. Scientists developed new carrier control encapsulation methods address these limits. Drug can be optimized by creating lipid compositions that match a drug's charge hydrophobicity. By selecting lipids adding co-solvents or surfactants, scientists increased formulations while maintaining stability. Nanotechnology has also created multifunctional with triggered personalized delivery. Surface modification like PEGylation ligand conjugation direct disease regions, improving therapeutic efficacy reducing off-target effects. In addition loading, researchers focused on spatiotemporal modulation release. Stimuli-responsive drugs response bodily signals. Liposomes pH- temperature-sensitive. To improve reduce systemic toxicity, added stimuli-responsive components membranes precisely kinetics. Advanced magnetic targeting ultrasound. Pro Drug, RNA approach may administration. Magnetic helps aggregate at illness sites improves delivery, whereas ultrasound-mediated facilitates on-demand encapsulated medicines. This covers recent preclinical research showing the promise for cancer, infectious diseases, neurological disorders inflammatory disorders. The transfer innovative from lab practice involves key difficulties such scalability, manufacturing difficulty, regulatory

Language: Английский

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Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 10, 2024

Language: Английский

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The potential of exosomes as a new therapeutic strategy for glioblastoma

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 203, P. 114460 - 114460

Published: Aug. 31, 2024

Glioblastoma (GBM) stands for the most common and aggressive type of brain tumour in adults. It is highly invasive, which explains its short rate survival. Little known about risk factors, current therapy still ineffective. Hence, efforts are underway to develop novel effective treatment approaches against this cancer. Exosomes being explored as a promising strategy conveying delivering therapeutic cargo GBM cells. They can fuse with cell membrane and, consequently, serve delivery systems context. Due their nanoscale size, exosomes cross blood-brain barrier (BBB), constitutes significant hurdle chemotherapeutic drugs used GBM. subsequently inhibit oncogenes, activate suppressor genes, induce immune responses, control growth. However, despite representing tool GBM, further research clinical studies regarding exosome biology, engineering, applications need be completed. Here, we sought review application through an in-depth analysis scientific on entire process, from isolation purification design transformation into anti-oncogenic drug systems. Surface modification enhance BBB penetration GBM-cell targeting also topic discussion.

Language: Английский

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Nanomaterial-Enhanced Microneedles: Emerging Therapies for Diabetes and Obesity

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1344 - 1344

Published: Oct. 21, 2024

Drug delivery systems (DDS) have improved therapeutic agent administration by enhancing efficacy and patient compliance while minimizing side effects. They enable targeted delivery, controlled release, bioavailability. Transdermal drug (TDDS) offer non-invasive medication evolved to include methods such as chemical enhancers, iontophoresis, microneedles (MN), nanocarriers. MN technology provides innovative solutions for chronic metabolic diseases like diabetes obesity using various types. For management, MNs continuous glucose monitoring, diabetic wound healing, painless insulin delivery. treatment, provide sustained transdermal of anti-obesity drugs or nanoparticles (NPs). Hybrid integrating wearable sensors smart materials enhance treatment effectiveness management. Nanotechnology has advanced nano-scaled liposomes polymeric NPs with MNs. In glucose-responsive facilitate At the same time, lipid nanocarriers in dissolving extended release stability absorption disorder therapies. DDS are advancing toward personalized treatments enhanced nanomaterials. These approaches can outcomes through precise real-time monitoring. However, widespread implementation faces challenges ensuring biocompatibility, improving technologies, scaling production, obtaining regulatory approval. This review will present recent advances developing applying nanomaterial-enhanced management also discussing challenges, limitations, future perspectives these DDS.

Language: Английский

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Metal oxide nanoparticles: Synthesis and applications in energy, biomedical, and environment sector

Journal of the Chinese Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Metal oxide nanoparticles (MONPs), pivotal in cutting‐edge research, are examined comprehensively this article. Encompassing definition, types, and applications, the focus intensifies on synthesis methods. Detailed discussions include chemical approaches for silver oxide, zinc nickel copper tin NPs. Additionally, article emphasizes burgeoning significance of green methods tailoring these The applications section underscores their role wastewater treatment, water splitting, biomedical fields. This targeted resource offers in‐depth insights into MONP synthesis, bridging gap between traditional environmentally conscious methodologies, researchers practitioners emerging technologies. In article, future perspectives also discussed.

Language: Английский

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Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Russian Journal of General Chemistry, Journal Year: 2023, Volume and Issue: 93(7), P. 1867 - 1899

Published: July 1, 2023

Abstract The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving solubility of hydrophobic bioactives. Further, liposomal vehicles reviewed, both advantages limitations discussed. Literature assay covers up-to-date information about last three five years, although brief background is given pioneer works addressing liposomes their evolution from bench bedside. Final part devoted modern modifications vesicular nanocarriers which can be adapted specific administration way due improved targeting properties, permeability, mucoadhesiveness possibility cross biological barriers. Therein, such kinds transfersomes, niosomes, ethosomes, chitosomes evaluated; separate sections focus formulations, i.e., phytosomes invasomes.

Language: Английский

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Peptide-Based Therapeutics in Cancer Therapy

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(10), P. 2679 - 2696

Published: Sept. 28, 2023

Language: Английский

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Incorporation of cellular membrane protein extracts into lipid nanoparticles enhances their cellular uptake and mRNA delivery efficiency

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113676 - 113676

Published: April 1, 2025

mRNA therapeutics enable transient expression of desired proteins within cells, holding great potential for advancements in vaccines, protein replacement therapies and gene editing approaches. Lipid nanoparticles (LNPs) are arguably the leading nanoplatform delivery due to their scalability transfection efficiency. However, limited ability target specific cell types, inefficient cellular uptake by many endosomal entrapment represent challenges improving targeted delivery. To address this, we evaluated a novel class LNPs functionalized with cell-derived membrane proteins, that refer as hybrisomes. Membrane extracts (MPEs) were isolated from cultured cells using mild detergent-based extraction protocol. Cy5-labeled encoding eGFP was used form hybrisomes investigate internalization efficiency via flow cytometry microscopy, MPE content incorporated into during microfluidic mixing. MPEs successfully lipid Remarkably, up 15-fold higher than LNPs, while improved 8-fold depending on Further studies confirmed enhanced is partially explained presence hybrisomes' unique morphology including bleb-like structures. Moreover, versatility demonstrated producing formulations different which led variations delivery, suggesting type derived influences biological function. These findings pave way development more effective nanotherapeutic strategies.

Language: Английский

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