Electrically Conductive Lignin Reinforced Polyacrylic Acid/Hyaluronic Acid Scaffolds With PEDOT:HA Nanoparticles DOI Creative Commons
Caitriona Winters, Marta Carsí, M. J. Sanchı́s

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)

Published: Oct. 1, 2024

ABSTRACT Hydrogel materials are continually developing in biomedical engineering and recently a lot of effort has gone into their engineered performance physiological applications. Porosity is an important characteristic for tissue scaffolds to allow enhanced biocompatibility the pore size needed dependent on application type which hydrogel being used regenerate. Regarding applications, use conducting polymers gaining popularity due promising potential stimulate cell growth proliferation through electrical stimulation. Building previous development by authors, this study focuses biocompatible scaffold with adjustable porosity swelling capabilities, robust mechanical properties, conductivity, high thermal stability. The objective work examine effect freezing temperature, cross‐linker final characteristics then determine possible porosity, degree, compression strength, biocompatibility, material were analyzed found be affected varied synthesis methods used. Overall, synthesized exhibit good increased fluorescence over 3 days 70% viability, stability up 200°C range 1725% 8472%. They also portray properties Young's Moduli 11 kPa 4.54 MPa 0.78–71.98 μm depending Through variations methods, highly porous, absorbent, stable have been synthesized. Notably, single recipe tailorable applications from drug delivery wound repair.

Language: Английский

Bioprinting of self-healing materials and nanostructures for biomedical applications: Recent advances and progresses on fabrication and characterization techniques DOI
Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib, Gelareh Mikaeeli Kangarshahi

et al.

Bioprinting, Journal Year: 2024, Volume and Issue: 38, P. e00335 - e00335

Published: Feb. 1, 2024

Language: Английский

Citations

11
Biomaterials-based hydrogels for therapeutic applications DOI Creative Commons
Mariana Chelu, Adina Magdalena Musuc

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

Citations

10
On the design of lignin reinforced acrylic acid/hyaluronic acid adhesive hydrogels with conductive PEDOT:HA nanoparticles DOI Creative Commons
Caitriona Winters, Marta Carsí, M. J. Sanchı́s

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 133093 - 133093

Published: June 12, 2024

Hydrogels are of great importance in biomedical engineering. They possess the ability to mimic bodily soft tissues, and this allows exciting possibilities for applications such as tissue engineering, drug delivery wound healing, however much work remains on stability mechanical robustness allow translation clinical applications. The herein describes synthesis analysis a biocompatible, versatile hydrogel that has tailorable swelling, high when swollen thermal stability. methods used produce with elasticity, good properties rapid crosslinking whilst displaying biocompatibility, adhesion, conductivity. It been shown cell viability samples is above 80 % all cases, Young's Modulus up 85 kPa swelling degrees were achieved. These materials show potential use numerous adhesive sensors, skin grafts systems.

Language: Английский

Citations

10
Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application DOI Open Access

Leonardo Donati,

Maria Luisa Valicenti,

Samuele Giannoni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386

Published: Sept. 26, 2024

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.

Language: Английский

Citations

3
Electrically Conductive Lignin Reinforced Polyacrylic Acid/Hyaluronic Acid Scaffolds With PEDOT:HA Nanoparticles DOI Creative Commons
Caitriona Winters, Marta Carsí, M. J. Sanchı́s

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)

Published: Oct. 1, 2024

ABSTRACT Hydrogel materials are continually developing in biomedical engineering and recently a lot of effort has gone into their engineered performance physiological applications. Porosity is an important characteristic for tissue scaffolds to allow enhanced biocompatibility the pore size needed dependent on application type which hydrogel being used regenerate. Regarding applications, use conducting polymers gaining popularity due promising potential stimulate cell growth proliferation through electrical stimulation. Building previous development by authors, this study focuses biocompatible scaffold with adjustable porosity swelling capabilities, robust mechanical properties, conductivity, high thermal stability. The objective work examine effect freezing temperature, cross‐linker final characteristics then determine possible porosity, degree, compression strength, biocompatibility, material were analyzed found be affected varied synthesis methods used. Overall, synthesized exhibit good increased fluorescence over 3 days 70% viability, stability up 200°C range 1725% 8472%. They also portray properties Young's Moduli 11 kPa 4.54 MPa 0.78–71.98 μm depending Through variations methods, highly porous, absorbent, stable have been synthesized. Notably, single recipe tailorable applications from drug delivery wound repair.

Language: Английский

Citations

2