Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 614 - 614

Published: Jan. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Language: Английский

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Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2710 - 2710

Published: Aug. 6, 2021

Ultra-processed foods (UPFs) consumption could affect gut microbiota diversity and profile. We aimed to evaluate the effects of UPFs on microbiota, considering role sex. The (using NOVA criteria) was assessed with a validated 137-item food-frequency questionnaire. Participants (n = 359) were classified into less than three servings per day 96) more five 90). Women men subclassified following same criteria. 16S rRNA sequencing performed from DNA fecal samples, differences in analyzed using EdgeR. relationship between bacteria by Spearman correlation comparison tertiles consumption. who consumed servings/day presented an increase Acidaminococcus, Butyrivibrio, Gemmiger, Shigella, Anaerofilum, Parabacteroides, Bifidobacterium, Enterobacteriales, Bifidobacteriales Actinobacteria decrease Melainabacter Lachnospira. positively associated pizza industrially processed dairy women. Men Granulicatella, Blautia, Carnobacteriaceae, Bacteroidaceae, Peptostreptococcaceae, Bacteroidia Bacteroidetes Anaerostipes Clostridiaceae. correlated meat. This study suggests that may composition differently women men.

Language: Английский

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Impact of Plant-Based Meat Alternatives on the Gut Microbiota of Consumers: A Real-World Study

Foods, Journal Year: 2021, Volume and Issue: 10(9), P. 2040 - 2040

Published: Aug. 30, 2021

Eating less meat is increasingly seen as a healthier, more ethical option. This leading to growing numbers of flexitarian consumers looking for plant-based alternatives (PBMAs) replace at least some the animal they consume. Popular PBMA products amongst flexitarians, including mince, burgers, sausages and meatballs, are often perceived low-quality, ultra-processed foods. However, we argue that mere industrial processing ingredients plant origin does not make product by default. To test our hypothesis, conducted randomised controlled trial assess changes gut microbiota group 20 participants who replaced several meat-containing meals per week with cooked compared these those experienced size-matched control. Stool samples were subjected 16S rRNA sequencing. The resulting raw data was analysed in compositionality-aware manner, using range innovative bioinformatic methods. Noteworthy included an increase butyrate metabolising potential—chiefly 4-aminobutyrate/succinate glutarate pathways—and joint abundance butyrate-producing taxa intervention We also observed decrease Tenericutes phylum control group. Based on findings, concluded occasional replacement dietary patterns can promote positive microbiome consumers.

Language: Английский

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Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Oct. 10, 2022

The production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows association between UPF adverse health outcomes, including inflammatory gastro-intestinal disorders obesity. gut microbiota been suggested as potential mediator effects on metabolism health. However, few studies have conducted in order to elucidate these aspects. Therefore, aim present study was assess cross-sectional associations a population senior subjects (n = 645) within frame PREDIMED-Plus trial. Eligible participants were men women (aged 55-75 years), without documented history cardiovascular disease at enrollment, with overweight/obesity (body mass index ≤ 27 <40 kg/m2) metabolic syndrome. Using information food frequency questionnaires, UPF, expressed percentage total dietary energy intake kcal/day, calculated considering those items classified group 4 NOVA system. Population categorized according tertiles consumption. Taxonomic fecal information, along blood biochemical parameters, anthropometric measurements clinical data obtained. Bioinformatics analysis performed composition We observed that allocated highest tertile (21.4 ± 5.0 % kcal/day) presented lower adherence MedDiet (p < 0.001) higher 0.001). taxonomic revealed significant (Benjamini-Hochberg adjusted p 0.2) positive specific taxa (T) consumption: Alloprevotella 0.041 vs. T2; 0.065 T3), Negativibacillus 0.096 Prevotella 0.116 Sutterella T2). positively associated overweight obesity In addition, related diseases low fruits vegetables, observed.

Language: Английский

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The Effect of ß-Glucan Prebiotic on Kidney Function, Uremic Toxins and Gut Microbiome in Stage 3 to 5 Chronic Kidney Disease (CKD) Predialysis Participants: A Randomized Controlled Trial

Nutrients, Journal Year: 2022, Volume and Issue: 14(4), P. 805 - 805

Published: Feb. 14, 2022

There is growing evidence that gut dysbiosis contributes to the progression of chronic kidney disease (CKD) owing several mechanisms, including microbiota-derived uremic toxins, diet and immune-mediated factors. The aim this study was investigate effect a ß-glucan prebiotic on function, toxins microbiome in stage 3 5 CKD participants. Fifty-nine participants were randomized either intervention group (n = 30) or control 29). primary outcomes assess function (urea, creatinine glomerular filtration rate), plasma levels total free (p-cresyl sulfate (pCS), indoxyl-sulfate (IxS), p-cresyl glucuronide (pCG) indoxyl 3-acetic acid (IAA) microbiota using 16S rRNA sequencing at baseline, week 8 14. (age 40.6 ± 11.4 y) 41.3 12.0 did not differ age any other socio-demographic variables baseline. no significant changes over 14 weeks. reduction toxin different time points, IxS weeks (p 0.003) < 0.001), pCS 0.006) pCG 0.001, p respectively) differences relative abundances genera between groups. Enterotyping revealed population consisted only two four enterotypes: Bacteroides 2 Prevotella. redundancy analysis showed few factors significantly affected microbiome: these included triglyceride body mass index 0.002), high- density lipoprotein 0.001) 0.002). altered intestinal origin favorably microbiome.

Language: Английский

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Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3365 - 3365

Published: July 28, 2023

Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown the development of obesity may be influenced by taxonomic shifts gut microbiota response consumption dietary fats. Further, these alterations have been promote important changes satiation signals including hormones (leptin, ghrelin, GLP-1, peptide YY and CCK) orexigenic anorexigenic neuropeptides (AgRP, NPY, POMC, CART) influence hyperphagia therefore obesity. In this review, we highlight mechanisms which can both locally gastrointestinal tract via microbiota-gut-brain communication. Then, describe effects interventions associated on satiety through microbiota-dependent mechanisms. Lastly, present optimizing therapies prebiotics, probiotics, synbiotics weight loss surgery help restore beneficial enhancing reduce subsequent Overall, better understanding fats induce taxonomical their impact signaling pathways will develop more targeted therapeutic delaying onset furthering its treatment.

Language: Английский

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A concept for international societally relevant microbiology education and microbiology knowledge promulgation in society

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(5)

Published: May 1, 2024

Executive summary Microbes are all pervasive in their distribution and influence on the functioning well‐being of humans, life general planet. Microbially‐based technologies contribute hugely to supply important goods services we depend upon, such as provision food, medicines clean water. They also offer mechanisms strategies mitigate solve a wide range problems crises facing humanity at levels, including those encapsulated sustainable development goals (SDGs) formulated by United Nations. For example, microbial can multiple ways decarbonisation hence confronting global warming, provide sanitation water billions people lacking them, improve soil fertility food production develop vaccines other reduce some cases eliminate deadly infections. foundation biotechnology, an increasingly growing business sector source employment, centre bioeconomy , Green Deal etc. But, because microbes largely invisible, they not familiar most people, so opportunities effectively prevent often missed decision‐makers, with negative consequences this entrains. To correct lack vital knowledge, International Microbiology Literacy Initiative–the IMiLI–is recruiting from microbiology community making freely available, teaching resources for curriculum societally relevant that be used levels learning. Its goal is society literate and, consequence, able take full advantage potential minimise activities. In addition about microbes, almost every lesson discusses have sustainability SDGs ability pressing societal inequalities. The thus teaches sustainability, needs citizenship. lessons reveal impacts activities our daily lives personal, family, community, national relevance decisions levels. And, effective, evidence‐based require only information but critical systems thinking, teach these key generic aspects deliberation. IMiLI learner‐centric, academic microbiology‐centric deal everyday issues. These span topics diverse owning caring companion animal, vast foods produced via processes, impressive geological formations created childhood illnesses how managed waste pollution. leverage exceptional excitement exploration discovery typifies much progress capture interest, inspire motivate educators learners alike. establishing Regional Centres translate into regional languages adapt them cultures, promote use assist employing them. Two now operational. constitute interface between resource creators educators–learners. As such, will collect analyse feedback end‐users transmit materials improved refined, new added response demand: thereby directly involved evolution resources. interactions educators–learners mediated establish dynamic synergistic relationships–a education ecosystem–in which become learners, optimised players/stakeholders empowered motivation increased. concept embraces principle embedded wider context societal, biosphere planetary needs, inequalities, confront us need decisioning, should ultimately lead better citizenship more resilient. Abstract planet Earth world: reactor countless microbially driven chemical transformations energy transfers push pull many geochemical cycling elements life, or amplify climate change (e.g., Nature Reviews Microbiology, 2019, 17, 569) impact organisms, humans. both ancestors chemistry allowed evolve Life's engines: How made earth habitable, 2023). understand functions, humans its live sustainably organisms sharing it, microbes. recent editorial (Environmental 21, 1513), advocated literacy society. Our based knowledge subject microbiology, multitude component topics, plus number additional disciplines vitally current microbiology. Rather it focused us–individuals/communities/nations/the human world–and reaching informed issues regularly us, ranging personal importance. words, understanding essential adulthood transition must acquired early school. 2019 Editorial marked launch Initiative, IMiLI. Here, present may achieved rationale underpinning it; type being realise framing treated responsibilities decision‐making; role local languages, according cultural serve hubs networks. featuring learner‐centric been selected inherent relevance, interest excite engage. Importantly, coherently integrate emphasise overarching stewardship thinking interdependencies processes. More broadly, emphasises multifarious applications leveraged human/animal, plant, environmental health, social equity, alleviate humanitarian deficits causes conflicts among peoples increase (Microbial Biotechnology, 2023, 16(6), 1091–1111). although primary target available (CC BY‐NC 4.0) schoolchildren educators, philosophy intended ages, abilities spectra worldwide: university education, lifelong learning, curiosity‐driven, web‐based acquisition public outreach. aim ecosystem democratises knowledge.

Language: Английский

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Daily Cashew and Brazil Nut Consumption Modifies Intestinal Health in Overweight Women on Energy-Restricted Intervention: A Randomized Controlled Trial (Brazilian Nuts Study)

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(3), P. 962 - 977

Published: Jan. 21, 2024

Language: Английский

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The Relationship Between Nutrition Habits, BMI, Anxiety, and Seborrheic Dermatitis

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

Seborrheic dermatitis (SD) is a chronic, inflammatory disease characterized by unknown etiopathogenesis. It affects skin areas rich in sebaceous glands. There are strong data on the relationship between nutrition habits, body mass index (BMI), psychoemotional status, and gland diseases such as acne, rosacea, androgenetic alopecia. However, there very little SD, BMI, status. We aimed to evaluate status patients with SD. One hundred SD 110 healthy controls aged 18-65 years were included. Adolescents Food Habits Checklist (AFHC), questionnaire form consisting information about habits Depression Anxiety Stress Scale-21 (DASS-21) completed participants, BMI was calculated. Severity of positively correlated (p = 0.018). Patients consumed more bread less fruits-vegetables 0.001, p 0.006). Margarine, animal fat, sugar consumption higher moderate severe 0.008, 0.050). AFHC score lower 0.009). DASS-21 anxiety subscale total scores group 0.035, 0.049). Nutrition may play critical role etiopathogenesis Healthy prevent occurrence exacerbation

Language: Английский

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Relationship between rumen microbial differences and traits among Hu sheep, Tan sheep, and Dorper sheep

Journal of Animal Science, Journal Year: 2022, Volume and Issue: 100(9)

Published: Aug. 11, 2022

Rumen microbes play an important role in the growth and development of ruminants. Differences variety will affect rumen community structure. The three excellent sheep breeds were selected for this study (Hu sheep, Tan Dorper sheep) have different uses origins. raised on same diet to 180 d age a consistent environment. 16S rDNA V3 V4 region sequencing was used assess individuals (60 per breed). There differences microbial diversity among (P < 0.05). Principal coordinate analysis showed that varieties separated, but also partially overlapped. Linear discriminant effect size identified total 19 biomarkers breeds. Of these biomarkers, five Hu significantly negatively correlated with average feed conversion rate Six which Ruminococcus positively body weight at 80 In Rikenellaceae_RC9_gut_group meat fat, volatile fatty acids (VFAs), such as butyric acid isobutyric may regulate mutton fat deposition by affecting concentration VFAs. Functional prediction revealed enrichment functional pathways small. All enriched functions, fermentation chemoheterotrophy. results show there are microorganisms breeds, influence host.The is most digestive organ ruminants, microflora plays process digestion. This compared key each breed, analyzed their correlation economic traits sheep. various traits. Therefore, we believe link between differential provides new idea trait improvement.

Language: Английский

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