Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(21)

Published: March 8, 2021

Abstract Bone tissue engineering (BTE) is a rapidly growing field aiming to create biofunctional that can integrate and degrade in vivo treat diseased or damaged tissue. It has become evident scaffold fabrication techniques are very important dictating the final structural, mechanical properties, biological response of implanted biomaterials. A comprehensive review current accomplishments on techniques, their structure, function properties for BTE provided herein. Different types biomaterials ranging from inorganic natural synthetic polymers related composites processing presented. Emergent scaffolding such as electrospinning, freeze‐drying, bioprinting, decellularization also discussed. Strategies improve vascularization potential immunomodulation, which considered grand challenge scaffolding,

Language: Английский

---

Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

Materials, Journal Year: 2019, Volume and Issue: 12(11), P. 1824 - 1824

Published: June 5, 2019

During the past two decades, tissue engineering and regenerative medicine field have invested in regeneration reconstruction of pathologically altered tissues, such as cartilage, bone, skin, heart valves, nerves tendons, many others. The 3D structured scaffolds hydrogels alone or combined with bioactive molecules genes cells are able to guide development functional engineered provide mechanical support during vivo implantation. Naturally derived synthetic polymers, bioresorbable inorganic materials, respective hybrids, decellularized been considered scaffolding biomaterials, owing their boosted structural, mechanical, biological properties. A diversity current treatment strategies, emergent technologies used for hydrogel processing, tissue-specific considerations Tissue (TE) purposes herein highlighted discussed depth. newest procedures focusing on behavior multi-cellular interactions native tissues further use vitro model processing also outlined. Completed ongoing preclinical research trials TE applications using hydrogels, challenges, future prospects presented.

Language: Английский

---

Tailoring Materials for Modulation of Macrophage Fate

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(12)

Published: Feb. 9, 2021

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity adaptive hold great promise for broad range of prophylactic therapeutic purposes. This review is focused on design strategies principles immunomodulatory from standpoint materials science to regulate macrophage fate, such activation, polarization, adhesion, migration, proliferation, secretion. It offers comprehensive survey discussion tunability material designs regarding physical, chemical, biological, dynamic cues modulating response. The tailorable encompasses surface properties, topography, mechanics, composition, dynamics. representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating are being exploited cancer immunotherapy, infection regeneration, inflammation resolution, vaccination. A perspective future research directions immunoregulatory also provided.

Language: Английский

---

Chronic wounds: Current status, available strategies and emerging therapeutic solutions

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 328, P. 532 - 550

Published: Sept. 22, 2020

Language: Английский

---

Steps in Mechanotransduction Pathways that Control Cell Morphology

Annual Review of Physiology, Journal Year: 2018, Volume and Issue: 81(1), P. 585 - 605

Published: Nov. 7, 2018

It is increasingly clear that mechanotransduction pathways play important roles in regulating fundamental cellular functions. Of the basic mechanical functions, determination of morphology critical. Cells typically use many mechanosensitive steps and different cell states to achieve a polarized shape through repeated testing microenvironment. Indeed, determined by microenvironment periodic activation motility, mechanotesting, mechanoresponse functions hormones, internal clocks, receptor tyrosine kinases. Patterned substrates controlled environments with defined rigidities limit range behavior influence state decisions are thus very useful for studying these steps. The recently rigidity sensing process provides good example how cells repeatedly test their also linked cancer. In general, aberrant extracellular matrix mechanosensing associated numerous conditions, including cardiovascular disease, aging, fibrosis, correlate changes tissue composition. Hence, detailed descriptions involved responding needed better understand both mechanisms homeostasis pathomechanisms human disease.

Language: Английский

---

Tissue-Specific Decellularization Methods: Rationale and Strategies to Achieve Regenerative Compounds

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(15), P. 5447 - 5447

Published: July 30, 2020

The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of ECM have been thoroughly used in engineering and regenerative medicine research, aiming to restore function damaged or dysfunctional tissues. Tissue decellularization gaining momentum as technique obtain potentially implantable decellularized (dECM) well-preserved key components. Interestingly, tissue-specific dECM becoming feasible option carry out advantages compared other approaches. This review provides an overview most common methods summarizes strategies adopted decellularize tissues, provide helpful guide for future research development.

Language: Английский

---

Biomaterials for In Situ Tissue Regeneration: A Review

Biomolecules, Journal Year: 2019, Volume and Issue: 9(11), P. 750 - 750

Published: Nov. 19, 2019

This review focuses on a somewhat unexplored strand of regenerative medicine, that is in situ tissue engineering. In this approach manufactured scaffolds are implanted the injured region for regeneration within patient. The scaffold designed to attract cells required volume subsequently proliferate, differentiate, and as consequence develop which time will degrade leaving just regenerated tissue. highlights wealth information available from studies ex-situ engineering about selection materials scaffolds. It clear there great opportunities use additive manufacturing prepare complex personalized we speculate by building knowledge technology, development could rapidly increase. Ex-situ handicapped need bioreactor where conditions, however optimized, may not be optimum accelerated growth maintenance cell function. We identify both methodologies prospect has created much promise but delivered little outside scope laboratory-based experiments. propose design selected remain at heart developments field predictive modelling can used optimization

Language: Английский

---

Fabrication, applications and challenges of natural biomaterials in tissue engineering

Applied Materials Today, Journal Year: 2020, Volume and Issue: 20, P. 100656 - 100656

Published: May 6, 2020

Language: Английский

---

Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

Advanced Healthcare Materials, Journal Year: 2019, Volume and Issue: 8(5)

Published: Feb. 4, 2019

Abstract Decellularized extracellular matrix (dECM) is a promising biomaterial for repairing cardiovascular tissue, as dECM most effectively captures the complex array of proteins, glycosaminoglycans, proteoglycans, and many other components that are found in native providing ideal cues regeneration repair damaged myocardium. can be used variety forms, such solid scaffolds maintain structure, or soluble materials form injectable hydrogels tissue repair. has recent success therapies, musculoskeletal, neural, liver tissues. This review focuses on context applications, with variations species sourcing, specifically discusses advances development, vitro studies, vivo implementation, clinical translation.

Language: Английский

---

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Polymers, Journal Year: 2020, Volume and Issue: 12(4), P. 844 - 844

Published: April 6, 2020

Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, may not provide suitable support cell adhesion, proliferation, and differentiation, which decelerates regeneration. To improve biological properties, frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, cytokines. Although there many papers describing synthesis properties of polymer proteins or few reviews comprehensively summarize these molecules. Thus, this review presents the current knowledge about most important peptides used modification This paper also describes influence addition on physicochemical, mechanical, scaffolds. Moreover, article sums up major applications biodegradable natural synthetic modified have been developed within past five years.

Language: Английский

---