International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(6), P. 2998 - 2998
Published: March 15, 2021
Interleukin
(IL)-4
and
IL-13
are
known
as
pleiotropic
Th2
cytokines
with
a
wide
range
of
biological
properties
functions
especially
in
immune
responses.
In
addition,
increasing
activities
have
also
been
determined
oncogenesis
tumor
progression
several
malignancies.
It
is
now
generally
accepted
that
IL-4
can
exert
effects
on
epithelial
cells
through
corresponding
receptors.
Type
II
receptor
(IL-4Rα/IL-13Rα1),
predominantly
expressed
non-hematopoietic
cells,
identified
to
be
the
main
target
for
both
tumors.
Moreover,
signal
by
binding
IL-13Rα2
receptor.
Structural
similarity
due
use
same
complex
generated
response
IL-4/IL-13
results
overlapping
but
distinct
signaling
pathways
functions.
The
aim
this
review
was
summarize
knowledge
about
their
receptors
pancreatic
cancer
order
understand
implication
tumorigenesis
developing
possible
new
diagnostic
therapeutic
targets.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(7)
Published: Feb. 10, 2021
Abstract
In
the
past
decade,
bacteria‐based
cancer
immunotherapy
has
attracted
much
attention
in
academic
circle
due
to
its
unique
mechanism
and
abundant
applications
triggering
host
anti‐tumor
immunity.
One
advantage
of
bacteria
lies
their
capability
targeting
tumors
preferentially
colonizing
core
area
tumor.
Because
are
pathogen‐associated
molecular
patterns
that
can
effectively
activate
immune
cells
even
tumor
immunosuppressive
microenvironment,
they
capable
enhancing
specific
recognition
elimination
cells.
More
attractively,
during
rapid
development
synthetic
biology,
using
gene
technology
enable
be
an
efficient
producer
immunotherapeutic
agents
led
many
creative
paradigms.
The
combination
nanomaterials
also
displays
infinite
imagination
multifunctional
endowment
for
immunotherapy.
current
progress
report
summarizes
recent
advances
with
foci
on
naive
bacteria‐,
engineered
bacterial
components‐based
immunotherapy,
at
same
time
discusses
future
directions
this
field
research
based
present
developments.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12567 - 12603
Published: Aug. 2, 2021
Immunotherapy
that
harnesses
the
human
immune
system
to
fight
cancer
has
received
widespread
attention
and
become
a
mainstream
strategy
for
treatment.
Cancer
immunotherapy
not
only
eliminates
primary
tumors
but
also
treats
metastasis
recurrence,
representing
major
advantage
over
traditional
treatments.
Recently
with
development
of
nanotechnology,
there
exists
much
work
applying
nanomaterials
on
basis
their
excellent
physiochemical
properties,
such
as
efficient
tissue-specific
delivery
function,
huge
specific
surface
area,
controllable
chemistry.
Consequently,
nanotechnology
holds
significant
potential
in
improving
efficacy
immunotherapy.
Nanotechnology-based
mainly
manifests
its
inhibitory
effect
via
two
different
approaches:
one
is
produce
an
effective
anti-tumor
response
during
tumorigenesis,
other
enhance
tumor
defense
ability
by
modulating
suppression
mechanism
microenvironment.
With
success
immunotherapy,
understanding
interaction
between
smart
nanomedicine
provided
vigorous
vitality
This
review
highlights
application,
progress,
prospect
process
immunoediting
discusses
several
engineering
methods
improve
efficiency
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
12(1), P. 92 - 106
Published: Aug. 14, 2021
Nanoparticulate
drug
delivery
systems
(Nano-DDSs)
have
emerged
as
possible
solution
to
the
obstacles
of
anticancer
delivery.
However,
clinical
outcomes
and
translation
are
restricted
by
several
drawbacks,
such
low
loading,
premature
leakage
carrier-related
toxicity.
Recently,
pure
nano-assemblies
(PDNAs),
fabricated
self-assembly
or
co-assembly
molecules,
attracted
considerable
attention.
Their
facile
reproducible
preparation
technique
helps
remove
bottleneck
nanomedicines
including
quality
control,
scale-up
production
translation.
Acting
both
carriers
cargos,
carrier-free
PDNAs
an
ultra-high
even
100%
loading.
In
addition,
combination
therapies
based
on
could
possibly
address
most
intractable
problems
in
cancer
treatment,
tumor
metastasis
resistance.
present
review,
latest
development
for
treatment
is
overviewed.
First,
classified
according
composition
assembly
mechanisms
discussed.
Furthermore,
co-delivery
summarized,
with
special
focus
improvement
therapeutic
outcomes.
Finally,
future
prospects
challenges
efficient
therapy
spotlighted.
Small,
Journal Year:
2021,
Volume and Issue:
17(52)
Published: Aug. 3, 2021
The
antitumor
efficiency
and
clinical
translation
of
traditional
nanomedicines
is
mainly
restricted
by
low
drug
loading,
complex
preparation
technology,
potential
toxicity
caused
the
overused
carrier
materials.
In
recent
decades,
small-molecule
prodrug
nanoassemblies
(SMP-NAs),
which
are
formed
self-assembly
prodrugs
themselves,
have
been
widely
investigated
with
distinct
advantages
ultrahigh
drug-loading
negligible
excipients-trigged
adverse
reaction.
Benefited
from
simple
process,
SMP-NAs
used
for
chemotherapy,
phototherapy,
immunotherapy,
tumor
diagnosis.
addition,
combination
therapy
based
on
accurate
co-delivery
behavior
can
effectively
address
challenges
heterogeneity
multidrug
resistance.
Recent
trends
in
outlined,
corresponding
mechanisms
discussed
detail.
Besides,
smart
stimuli-responsive
summarized,
special
emphasis
structure-function
relationships.
Finally,
outlooks
cancer
highlighted.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11306 - 11306
Published: Oct. 20, 2021
Cancer
is
a
condition
caused
by
many
mechanisms
(genetic,
immune,
oxidation,
and
inflammatory).
Anticancer
therapy
aims
to
destroy
or
stop
the
growth
of
cancer
cells.
Resistance
treatment
theleading
cause
inefficiency
current
standard
therapies.
Targeted
therapies
are
most
effective
due
low
number
side
effects
resistance.
Among
small
molecule
natural
compounds,
flavonoids
particular
interest
for
theidentification
new
anticancer
agents.
Chalcones
precursors
all
have
biological
activities.
The
activity
chalcones
ability
these
compounds
act
on
targets.
Natural
chalcones,
such
as
licochalcones,
xanthohumol
(XN),
panduretin
(PA),
loncocarpine,
been
extensively
studied
modulated.
Modification
basic
structure
in
order
obtain
with
superior
cytotoxic
properties
has
performed
modulating
aromatic
residues,
replacing
residues
heterocycles,
obtaining
hybrid
molecules.
A
huge
chalcone
derivatives
diaryl
ether,
sulfonamide,
amine
obtained,
their
presence
being
favorable
activity.
amino
group
aminochalconesis
always
antitumor
This
why
molecules
different
nitrogen
hetercycles
obtained.
From
these,
azoles
(imidazole,
oxazoles,
tetrazoles,
thiazoles,
1,2,3-triazoles,
1,2,4-triazoles)
importance
identification
Briefings in Bioinformatics,
Journal Year:
2021,
Volume and Issue:
22(5)
Published: Jan. 6, 2021
Abstract
Anticancer
peptides
constitute
one
of
the
most
promising
therapeutic
agents
for
combating
common
human
cancers.
Using
wet
experiments
to
verify
whether
a
peptide
displays
anticancer
characteristics
is
time-consuming
and
costly.
Hence,
in
this
study,
we
proposed
computational
method
named
identify
via
deep
representation
learning
features
(iACP-DRLF)
using
light
gradient
boosting
machine
algorithm
features.
Two
kinds
sequence
embedding
technologies
were
used,
namely
soft
symmetric
alignment
unified
(UniRep)
embedding,
both
which
involved
neural
network
models
based
on
long
short-term
memory
networks
their
derived
networks.
The
results
showed
that
use
greatly
improved
capability
discriminate
from
other
peptides.
Also,
UMAP
(uniform
manifold
approximation
projection
dimension
reduction)
SHAP
(shapley
additive
explanations)
analysis
proved
UniRep
have
an
advantage
over
identification.
python
script
pretrained
could
be
downloaded
https://github.com/zhibinlv/iACP-DRLF
or
http://public.aibiochem.net/iACP-DRLF/.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(11), P. 3834 - 3834
Published: Oct. 27, 2021
Cancer
is
one
of
the
leading
causes
death
globally,
associated
with
multifactorial
pathophysiological
components.
In
particular,
genetic
mutations,
infection
or
inflammation,
unhealthy
eating
habits,
exposition
to
radiation,
work
stress,
and/or
intake
toxins
have
been
found
contribute
development
and
progression
cancer
disease
states.
Early
detection
proper
treatment
enhance
chances
survival
healing,
but
side
effects
anticancer
drugs
still
produce
detrimental
responses
that
counteract
benefits
in
terms
hospitalization
survival.
Recently,
several
natural
bioactive
compounds
were
possess
properties,
capable
killing
transformed
cancerous
cells
without
being
toxic
their
normal
counterparts.
This
effect
occurs
when
products
are
conventional
treatments,
thereby
suggesting
nutraceutical
supplementation
may
successful
therapy.
review
aims
discuss
current
literature
on
four
extracts
mostly
characterized
by
a
specific
polyphenolic
profile.
activities
reported
support
treatment:
(1)
inhibition
cell
proliferation,
(2)
antioxidant
activity,
(3)
anti-inflammatory
activity.
On
other
hand,
owing
attenuation
therapies,
antioxidants
improving
compliance
patients
undergoing
treatment.
Thus,
supplementation,
along
drug
treatment,
be
considered
for
better
cancer.
It
should
noted,
however,
data
from
studies
plant
preparations
discussed,
it
appropriate
ensure
experiments
conducted
accordance
accepted
pharmacological
research
practices
so
as
not
disclose
information
only
partially
correct.
