Strategies to Overcome Antimicrobial Resistance in Nosocomial Infections, A Review and Update DOI

Nasim Bakhtiyari,

Safar Farajnia,

Samaneh Ghasemali

et al.

Infectious Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 24(6)

Published: Jan. 29, 2024

Abstract: Nosocomial infections, also known as healthcare-associated are a significant global concern due to their strong association with high mortality and morbidity in both developed developing countries. These infections caused by variety of pathogens, particularly the ESKAPE group bacteria, which includes six pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. bacteria have demonstrated noteworthy resistance different antibiotics. : Antimicrobial mechanisms can manifest various forms, including restricting drug uptake, modifying targets, inactivating drugs, active efflux, biofilm formation. Accordingly, strategies been combat antibiotic-resistant bacteria. encompass development new antibiotics, utilization bacteriophages that specifically target these antimicrobial combination therapy use peptides or enzymes genomes essential proteins resistant Among promising approaches overcome antibiotic resistance, CRISPR/Cas system stands out offers many advantages. This enables precise efficient editing genetic material at specific locations genome. Functioning bacterial "adaptive immune system," recognizes, degrades, remembers foreign DNA sequences through spacer segments transcribed into CRISPR RNAs (crRNA). paper has focused on nosocomial involved hospital underlying currently employed address this issue. Special emphasis placed application technology for overcoming resistance.

Language: Английский

Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications DOI Creative Commons
Jasminka Talapko,

Tomislav Meštrović,

Martina Juzbašić

et al.

Antibiotics, Journal Year: 2022, Volume and Issue: 11(10), P. 1417 - 1417

Published: Oct. 16, 2022

The growing emergence of antimicrobial resistance represents a global problem that not only influences healthcare systems but also has grave implications for political and economic processes. As the discovery novel agents is lagging, one solutions innovative therapeutic options would expand our armamentarium against this hazard. Compounds interest in many such studies are peptides (AMPs), which actually represent host’s first line defense pathogens involved innate immunity. They have broad range activity Gram-negative Gram-positive bacteria, fungi, viruses, with specific mechanisms action utilized by different AMPs. Coupled lower propensity development, it becoming clear AMPs can be seen as emerging very promising candidates more pervasive usage treatment infectious diseases. However, their use quotidian clinical practice without challenges. In review, we aimed to summarize state-of-the-art evidence on structure AMPs, well provide detailed information activity. We present contemporary trials application highlight beyond diseases potential challenges may arise increasing availability.

Language: Английский

Citations

137
Bioactive Synthetic Polymers DOI
Kenward Jung, Nathaniel Corrigan, Edgar H. H. Wong

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(2)

Published: Oct. 5, 2021

Abstract Synthetic polymers are omnipresent in society as textiles and packaging materials, construction medicine, among many other important applications. Alternatively, natural play a crucial role sustaining life allowing organisms to adapt their environments by performing key biological functions such molecular recognition transmission of genetic information. In general, the synthetic polymer worlds completely separated due inability for perform specific functions; some cases, cause uncontrolled unwanted responses. However, owing advancement polymerization techniques recent years, new have emerged that provide targeted peptides, or present antiviral, anticancer, antimicrobial activities. this review, emergence generation bioactive bioapplications summarized. Finally, future opportunities area discussed.

Language: Английский

Citations

112
Aggregation-Induced Emission Nanoparticles for Single Near-Infrared Light-Triggered Photodynamic and Photothermal Antibacterial Therapy DOI
Wentao Wang, Fan Wu, Qicheng Zhang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7961 - 7970

Published: May 3, 2022

Phototheranostics is a potential area for precision medicine, which has received increasing attention antibacterial applications. Integrating all phototheranostic modalities in single molecule and achieving precise spatial colocalization challenging task because of the complexity energy dissipation molecular design. Here, type quaternary amine functionalized aggregation-induced emission (AIE), AIEgen, was synthesized used to produce singlet oxygen (1O2) heat, were eradicate bacteria. With introduction positive charge AIE nanoparticles (AIE NPs) could selectively target Notably, NPs displayed obvious performance against Gram-positive bacteria (Staphylococcus aureus) Gram-negative (Escherichia coli). The rates as high 99.9% 99.8% S. aureus E. coli, respectively. Therefore, our results suggested acting broad-spectrum antimicrobial materials, provided strategy treating different microorganisms.

Language: Английский

Citations

104
Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections DOI
Ruige Yang,

Enhua Hou,

Wanqing Cheng

et al.

Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 65(24), P. 16879 - 16892

Published: Dec. 13, 2022

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) continue to endanger public health. Here, we report the synthesis of neolignan isomagnolone (I) and its isomer II, preparation a series novel neolignan-antimicrobial peptide (AMP) mimic conjugates. Notably, conjugates III5 III15 exhibit potent anti-MRSA activity in vitro vivo, comparable that vancomycin, current effective treatment for MRSA. Moreover, display not only fast-killing kinetics low resistance frequency but also toxicity as well effects on bacterial biofilms. Mechanism studies reveal rapid bactericidal through binding phosphatidylglycerol (PG) cardiolipin (CL) membrane, thereby disrupting cell membranes allowing increased reactive oxygen species (ROS) protein DNA leakage. The results indicate these neolignan-AMP could be promising antimicrobial candidates combating MRSA infections.

Language: Английский

Citations

99
Titanium carbide MXene-based hybrid hydrogel for chemo-photothermal combinational treatment of localized bacterial infection DOI

Yuwei Zheng,

Yilang Yan,

Liming Lin

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 142, P. 113 - 123

Published: Feb. 19, 2022

Language: Английский

Citations

96
Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides DOI Creative Commons
Xiaofang Luo,

Huifang Chen,

Yannan Song

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 181, P. 106363 - 106363

Published: Dec. 16, 2022

Language: Английский

Citations

77
Peptide-Based Agents for Cancer Treatment: Current Applications and Future Directions DOI Open Access
Nguyễn Thị Thanh Nhàn, Tohru Yamada, Kaori Yamada

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12931 - 12931

Published: Aug. 18, 2023

Peptide-based strategies have received an enormous amount of attention because their specificity and applicability. Their tumor-targeting ability are applied to diagnosis treatment for cancer patients. In this review, we will summarize recent advancements future perspectives on peptide-based treatment. The literature search was conducted identify relevant articles It performed using PubMed in English until June 2023. Information clinical trials also obtained from ClinicalTrial.gov. Given that several advantages such as targeted delivery the diseased area, personalized designs, relatively small sizes, simple production process, bioactive peptides having anti-cancer activities (anti-cancer or ACPs) been tested pre-clinical settings trials. capability tumor targeting is essentially useful peptide-drug conjugates (PDCs), diagnosis, image-guided surgery. Immunomodulation with peptide vaccines has extensively Despite advantages, FDA-approved agents solid still limited. This review provide a detailed overview current approaches, design strategies, routes administration, new technological advancements. We highlight success limitations therapies

Language: Английский

Citations

55
Antimicrobial peptides: Opportunities and challenges in overcoming resistance DOI Creative Commons

Cezara Bucataru,

Corina Ciobănaşu

Microbiological Research, Journal Year: 2024, Volume and Issue: 286, P. 127822 - 127822

Published: June 26, 2024

Antibiotic resistance represents a global health threat, challenging the efficacy of traditional antimicrobial agents and necessitating innovative approaches to combat infectious diseases. Among these alternatives, peptides have emerged as promising candidates against resistant pathogens. Unlike antibiotics with only one target, can use different mechanisms destroy bacteria, low toxicity mammalian cells compared many conventional antibiotics. Antimicrobial (AMPs) encouraging antibacterial properties are currently employed in clinical treatment pathogen infection, cancer, wound healing, cosmetics, or biotechnology. This review summarizes discusses drug resistance, limitations challenges AMPs peptide applications for combating drug-resistant bacterial infections, strategies enhance their capabilities.

Language: Английский

Citations

45
Three Rounds of Stability-Guided Optimization and Systematical Evaluation of Oncolytic Peptide LTX-315 DOI

Xing‐Yan Fu,

Hao Yin,

Xi‐Tong Chen

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 3885 - 3908

Published: Jan. 26, 2024

Oncolytic peptides represent promising novel candidates for anticancer treatments. In our efforts to develop oncolytic possessing both high protease stability and durable efficiency, three rounds of optimization were conducted on the first-in-class peptide LTX-315. The robust synthetic method, in vitro vivo activity, mechanism investigated. D-type represented by FXY-12 possessed significantly improved proteolytic sustained efficiency. Strikingly, hybrid FXY-30, containing one two camptothecin moieties, exhibited most potent activities. explorations indicated that FXY-30 rapid membranolytic effects induced severe DNA double-strand breaks trigger cell apoptosis. Collectively, this study not only established strategies improve potential but also provided valuable references future development peptides-based chemotherapeutics.

Language: Английский

Citations

26
Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Peptide, by Triggering Oxidative Stress and Cell Cycle Arrest in Candida auris DOI Creative Commons
Irfan A. Rather, Jamal S. M. Sabir, Amer H. Asseri

et al.

Journal of Fungi, Journal Year: 2022, Volume and Issue: 8(2), P. 204 - 204

Published: Feb. 20, 2022

Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing severe invasive infections associated with high mortality rates in hospitalized individuals. Distinct from other species, C. auris can persist longer periods on different surfaces and resistant to all of the major classes antifungal drugs. Therefore, there urgent need new antimycotic drugs improved efficacy reduced toxicity. The development antifungals based antimicrobial peptides various sources considered a promising alternative. In this study, we examined vitro anti-yeast activity human cathelicidin LL-37 against clinical strains alone combination by broth microdilution assay. To understand mechanism action, cell envelopes, cycle arrest, effect oxidative stress enzymes were studied using standard protocols. minimum inhibitory fungicidal concentrations ranged 25–100 50–200 µg/mL, respectively. A interaction 1:1 ratio (cathelicidin LL-37: drug) resulted 70% synergy fluconazole 100% amphotericin B caspofungin. Assessment membrane propidium iodide assay after exposure linked permeabilization inhibition growth viability. These results backed up scanning electron microscopy studies demonstrating that caused cells undergo extensive surface changes. Spectrophotometric analysis revealed as evident significant increase primary antioxidant enzymes. addition, inhibited accumulated S phase. these specify potential developing effective anti-Candida agent.

Language: Английский

Citations

41