Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy DOI
Yujie Pan, Yangyang Li, Xin Zhou

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

The management of diabetic wounds faces significant challenges due to the excessive activation reactive oxygen species (ROS), dysregulation inflammatory response, and impaired angiogenesis. A substantial body evidence suggests that aforementioned diverse factors contributing delayed healing may be associated with autophagy. Impaired autophagy leads endothelial fibroblast dysfunction impedes macrophage phenotypic transformation. This disruption hinders angiogenesis extracellular matrix deposition, ultimately culminating in wound healing. Therefore, biomaterials possessing regulatory functions hold potential for clinical applications enhancing wounds. hybrid multifunctional hydrogel (GelMa@SIS-Qu) has been developed, comprising methacrylamide gelatin (GelMa), a small intestine submucosal acellular (SIS), quercetin nanoparticles, which demonstrates capability promote promotion not only reduces ROS levels cells enhances their antioxidant activity but also mitigates ROS-induced cell apoptosis, thereby promoting Furthermore, facilitates transformation macrophages from M1 phenotype M2 phenotype. study investigates distinctive mechanisms GelMa@SIS-Qu proposes promising therapeutic strategy treating diabetes-related

Language: Английский

Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity DOI Creative Commons
Jiaying Li, Jinjin Ma, Heng Sun

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(21)

Published: May 26, 2023

Implant-associated infection is a major threat affecting the success of orthopedic surgeries. Although various materials scavenge bacteria by generating reactive oxygen species (ROS), intrinsic inability ROS to distinguish from cells notably limits therapeutic effects. Here, we found that arginine carbon dots (Arg-CDs) were transformed exhibited supreme antibacterial and osteoinductive activity. We further designed Schiff base bond between Arg-CDs aldehyde hyaluronic acid/gelatin methacryloyl (HG) hydrogel release in response acidic bone injury microenvironment. The free could selectively kill excessive ROS. Furthermore, Arg-CD-loaded HG composite showed excellent activity through inducing M2 polarization macrophages up-regulating interleukin-10 (Il10) expression. Together, our findings revealed transformation into zero-dimensional endow material with exceptional activity, favoring regeneration infectious bone.

Language: Английский

Citations

71
A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing DOI Creative Commons
Jinjian Huang, Rong Yang, Jiao Jiao

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 29, 2023

High glucose-induced vascular endothelial injury is a major pathological factor involved in non-healing diabetic wounds. To interrupt this process, we design an all-peptide printable hydrogel platform based on highly efficient and precise one-step click chemistry of thiolated γ-polyglutamic acid, glycidyl methacrylate-conjugated arginine-glycine-aspartate sequences. Vascular growth 165-overexpressed human umbilical vein cells are printed using platform, hence fabricating living material with high cell viability spatial distribution control. This cell-laden accelerates the wound healing rats unabated 165 release, which promotes angiogenesis alleviates damages mitochondria, thereby reducing tissue hypoxia, downregulating inflammation, facilitating extracellular matrix remodeling. Together, study offers promising strategy for tissue-friendly, high-efficient, accurate 3D delivery self-renewable therapy.

Language: Английский

Citations

69
Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives DOI Creative Commons

Anthony Ko,

Caizhi Liao

BMEMat, Journal Year: 2023, Volume and Issue: 1(3)

Published: June 30, 2023

Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.

Language: Английский

Citations

67
Porcupine-inspired microneedles coupled with an adhesive back patching as dressing for accelerating diabetic wound healing DOI
Tianqi Liu,

Yanfang Sun,

Guohua Jiang

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 160, P. 32 - 44

Published: Feb. 9, 2023

Language: Английский

Citations

59
Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives DOI

Tejaswini Kolipaka,

Giriraj Pandey,

Noella Abraham

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537

Published: Nov. 2, 2023

Language: Английский

Citations

55
Hyaluronic Acid‐Based Reactive Oxygen Species‐Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing DOI
Chen Shi, Ying Zhang,

Guanfu Wu

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)

Published: Nov. 9, 2023

Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is assess a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for the purpose diabetic wound healing. A (HA@Cur@Ag) successfully synthesized with dual antioxidant, antibacterial, anti-inflammatory properties by crosslinking thiol hyaluronic acid (SH-HA) disulfide-bonded hyperbranched polyethylene glycol (HB-PBHE) through Michael addition; while, incorporating curcumin liposomes silver nanoparticles (AgNPs). HA@Cur@Ag exhibits favorable biocompatibility, degradability, injectivity. outcomes in vitro vivo experiments demonstrate that can effectively be loaded release liposomes, as well ions, thereby facilitating healing multiple mechanisms, including ROS scavenging, bactericidal activity, effects, promotion angiogenesis. Transcriptome sequencing reveals suppresses activation tumour necrosis factor (TNF)/nuclear κB (NF-κB) pathway ameliorate oxidative stress inflammation These findings suggest ROS-responsive hydrogel, which possesses ability precisely coordinate integrate intricate biological molecular processes involved healing, notable potential expediting

Language: Английский

Citations

50
Hydrogel-based dressings designed to facilitate wound healing DOI Creative Commons
Wei Zhang, Lulu Liu, Hui Cheng

et al.

Materials Advances, Journal Year: 2023, Volume and Issue: 5(4), P. 1364 - 1394

Published: Dec. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Language: Английский

Citations

44
A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing DOI

Xinrang Zhai,

Honghua Hu,

Miner Hu

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122064 - 122064

Published: March 15, 2024

Language: Английский

Citations

32
Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers DOI
Chaofan Zhang, Erya Cai, Xiaoliang Qi

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150756 - 150756

Published: March 26, 2024

Language: Английский

Citations

28
A DNA-inspired injectable adhesive hydrogel with dual nitric oxide donors to promote angiogenesis for enhanced wound healing DOI Creative Commons

Yongsheng Zheng,

Yang Dong, Botao Gao

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 176, P. 128 - 143

Published: Jan. 24, 2024

Chronic diabetic wounds are a severe complication of diabetes, often leading to high treatment costs and amputation rates. Numerous studies have revealed that nitric oxide (NO) therapy is promising option because it favours wound revascularization. Here, base-paired injectable adhesive hydrogels (CAT) were prepared using adenine- thymine-modified chitosan (CSA CST). By further introducing S-nitrosoglutathione (GSNO) binary L-arginine (bArg), we obtained NO sustained-release hydrogel (CAT/bArg/GSON) was more suitable for the chronic wounds. The results showed expression HIF-1α VEGF upregulated in CAT/bArg/GSON group, improved blood vessel regeneration observed, indicating an important role NO. In addition, research findings following with hydrogel, viability Staphylococcus aureus Escherichia coli decreased 14 ± 2% 6 1%, respectively. Moreover, microenvironment improved, as evidenced by 60 1% clearance DPPH. particular, histological examination immunohistochemical staining treated CAT/bArg/GSNO exhibited denser neovascularization, faster epithelial tissue regeneration, thicker collagen deposition. Overall, this study proposes effective strategy prepare dressings dual donors. functionality has been thoroughly demonstrated on vascular could be potential promoting healing. This article prepares utilizing principle complementary base pairing, which offers several advantages, including good adhesion, biocompatibility, flow properties, making material dressings. Loaded GSNO bArg can steadily release through degradation gel. Then, released not only possesses antioxidant properties but also continue generate small amount under action NOS. design achieves sustained stable supply at site, maximizing angiogenesis-promoting antibacterial effects More neovascularization abundant observed regenerated tissues. provides repair wound.

Language: Английский

Citations

22