ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(30), P. 39064 - 39078
Published: July 19, 2024
The
bacterial
infection
and
poor
osseointegration
of
Ti
implants
could
significantly
compromise
their
applications
in
bone
repair
replacement.
Based
on
the
carrier
separation
ability
heterojunction
redox
reaction
pseudocapacitive
metal
oxides,
we
report
an
electrically
responsive
TiO2-SnO2-RuO2
coating
with
a
multilayered
heterostructure
implant.
Owing
to
band
gap
structure
coating,
electron
carriers
are
easily
enriched
at
surface,
enabling
response
endogenous
electrical
stimulation
bone.
With
formation
SnO2-RuO2
pseudocapacitance
modified
postcharging
mode
can
change
surface
chemical
state
due
reaction,
enhancing
antibacterial
osteogenesis-related
gene
expression
human
marrow
mesenchymal
stem
cells.
attraction
for
Ca2+,
only
negatively
postcharged
SnO2@RuO2
promote
apatite
deposition.
vivo
experiment
reveals
that
S-SnO2@RuO2-NP
effectively
kill
bacteria
colonized
synostosis
bonding
interface.
Thus,
charging
is
good
strategy
endow
excellent
osseointegration.
Journal of Composites Science,
Journal Year:
2025,
Volume and Issue:
9(3), P. 133 - 133
Published: March 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(45)
Published: Oct. 11, 2024
Abstract
Oral
ulcers
can
be
addressed
using
various
biomaterials
designed
to
deliver
medications
or
cytokines.
Nevertheless,
the
effectiveness
of
these
substances
is
frequently
limited
in
many
patients
due
poor
adherence,
short
retention
time
mouth,
and
less‐than‐optimal
drug
efficacy.
In
this
study,
a
new
hydrogel
patch
(FSH3)
made
silk
fibroin/hyaluronic
acid
matrix
with
light‐sensitive
adhesive
qualities
infused
ferric
iron/shikonin
nanoparticles
enhance
healing
effects
presented.
Initially,
forms
an
barrier
over
mucosal
lesions
through
straightforward
local
injection,
solidifying
when
exposed
UV
light.
Subsequently,
FSH3
demonstrates
superior
reactive
oxygen
species
elimination
near‐infrared
photothermal
bactericidal
activity.
These
characteristics
support
bacterial
regulate
oxidative
levels,
promoting
wound's
progression
from
inflammation
tissue
regeneration.
diabetic
rat
model
mimicking
oral
ulcers,
significantly
speeds
up
by
adjusting
inflammatory
environment
injured
tissue,
maintaining
balance
microbiota,
faster
re‐epithelialization.
Overall,
shows
potential
for
rapid
wound
recovery
may
transform
therapeutic
methods
managing
diabetes.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
41, P. 193 - 206
Published: July 20, 2024
Regulating
macrophage
phenotypes
to
reconcile
the
conflict
between
bacterial
suppression
and
tissue
regeneration
is
ideal
for
treating
infectious
skin
wounds.
Here,
an
injectable
immunoregulatory
hydrogel
(SrmE20)
that
sequentially
drives
phenotypic
polarization
(M0
M1,
then
M2)
was
constructed
by
integrating
anti-inflammatory
components
proinflammatory
solvents.
Hydrogel
microparticles
have
been
proved
to
be
curative
diabetic
wounds.
Current
trends
focus
on
the
integration
of
bioactive
matrix
and
their
smart
stimulus-responsive
release
meet
complex
demand
regeneration
in
wound.
In
this
paper,
we
present
novel
stem
cell
exosome-encapsulated
Chinese
herb
glycyrrhizic
acid
(GA)
hydrogel
for
wound
healing.
The
integrated
GA
endows
with
antibacterial
properties,
while
encapsulated
exosomes
impart
them
pro-angiogenesis
ability.
addition,
as
black
phosphorus
is
incorporated
into
these
hybrid
microparticles,
profile
could
controllable
under
near-infrared
irradiation
due
excellent
photothermal
effect
reversible
phase
transformation
properties
GA.
Based
features,
demonstrated
that
can
effectively
kill
bacteria,
scavenge
free
radical,
promote
angiogenesis
from
vitro
experiments.
Besides,
they
also
markedly
accelerate
healing
process
by
down-regulating
inflammation
promoting
collagen
deposition
bacteria-infected
vivo
These
results
indicate
proposed
exosome-integrated
great
potential
clinical
treatment.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 27, 2024
Abstract
Existing
methods
for
treating
diabetic
oral
ulcers
often
fall
short
in
clinical
environments
due
to
potential
bacterial
contamination,
oxidative
harm,
and
hindered
angiogenesis
throughout
the
healing
process.
Here,
a
hydrogel
patch
(HYG2)
have
been
developed
local
situ
application.
HYG2
comprises
oxidized
pullulan,
quaternized
chitosan,
eumelanin
nanoparticles
derived
from
cuttlefish
ink.
These
components
work
together
efficiently
heal
wounds
associated
with
ulcers.
Application
begins
simple
injection
that
quickly
forms
protective
barrier
over
mucosa,
effectively
stopping
bleeding
counteracting
inflammatory
agents.
is
distinguished
by
its
strong
antibacterial
properties
capacity
eliminate
reactive
oxygen
species,
promoting
bacteria
clearance
managing
stress,
which
accelerates
phase
inflammation
tissue
regeneration.
Additionally,
HYG2's
3D
structure,
incorporating
elements
natural
sources,
offers
exemplary
support
structural
nutritional
cell
needs.
This
enhancement
fosters
adhesion,
migration,
proliferation,
along
further
during
mucosal
remodeling.
Ultimately,
fully
absorbed
body
after
serving
therapeutic
functions.
Evidence
vitro
vivo
studies
shows
markedly
wound
repair,
making
it
promising
treatment
