Biomedical Technology, Journal Year: 2024, Volume and Issue: 8, P. 17 - 49
Published: Oct. 1, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 457, P. 141362 - 141362
Published: Jan. 7, 2023
Language: Английский
Citations
51
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129828 - 129828
Published: Jan. 29, 2024
Language: Английский
Citations
34
Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(10), P. 688 - 699
Published: Sept. 4, 2023
Language: Английский
Citations
30
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 15, 2024
This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on transition from acute radiation damage to a fibrotic state. It reviewed cellular and molecular responses radiation, highlighting role myofibroblasts significant impact Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The delves into epigenetic regulation gene expression, contribution extracellular matrix proteins microenvironment, immune system context fibrosis. Additionally, it discusses potential biomaterials artificial intelligence medical research advance understanding treatment suggesting future directions involving bioinformatics personalized therapeutic strategies enhance patient quality life.
Language: Английский
Citations
11
Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 492 - 520
Published: May 30, 2024
Endogenous regeneration is becoming an increasingly important strategy for wound healing as it facilitates skin's own regenerative potential self-healing, thereby avoiding the risks of immune rejection and exogenous infection. However, currently applied biomaterials inducing endogenous skin are simplistic in their structure function, lacking ability to accurately mimic intricate tissue regulate disordered microenvironment. Novel biomimetic with precise structure, chemical composition, biophysical properties offer a promising avenue achieving perfect regeneration. Here, we outline recent advances materials induced from aspects structural functional mimicry, physiological process regulation, property design. Furthermore, novel techniques including situ reprograming, flexible electronic skin, artificial intelligence, single-cell sequencing, spatial transcriptomics, which have contribute development highlighted. Finally, prospects challenges further research application discussed. This review provides reference address clinical problems rapid high-quality
Language: Английский
Citations
10
Biomimetics, Journal Year: 2023, Volume and Issue: 8(5), P. 446 - 446
Published: Sept. 21, 2023
Nanozymes represent a category of nano-biomaterial artificial enzymes distinguished by their remarkable catalytic potency, stability, cost-effectiveness, biocompatibility, and degradability. These attributes position them as premier biomaterials with extensive applicability across medical, industrial, technological, biological domains. Following the discovery ferromagnetic nanoparticles peroxidase-mimicking capabilities, research endeavors have been dedicated to advancing nanozyme utilization. Their capacity emulate functions natural has captivated researchers, prompting in-depth investigations into potential applications. This exploration yielded insights innovations in various areas, including detection mechanisms, biosensing techniques, device development. exhibit diverse compositions, sizes, forms, resembling molecular entities such proteins tissue-based glucose. rapid impact on body necessitates comprehensive understanding intricate interplay. As each day witnesses emergence novel methodologies technologies, integration nanozymes continues surge, promising enhanced comprehension times ahead. review centers expansive deployment advancement materials, encompassing biomedical, biotechnological, environmental contexts.
Language: Английский
Citations
17
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2054 - 2069
Published: March 23, 2024
Cell migration is vital for many fundamental biological processes and human pathologies throughout our life. Dynamic molecular changes in the tissue microenvironment determine modifications of cell movement, which can be reflected either individually or collectively. Endothelial (EC) migratory adaptation occurs during several events phenomena, such as endothelial injury, vasculogenesis, angiogenesis, under both normal highly inflammatory conditions. Several advantageous supported by biomaterials. cells are used combination with various types biomaterials to design scaffolds promoting formation mature blood vessels within engineered structures. Appropriate selection, terms scaffolding properties, promote desirable behavior varying degrees. An increasing amount research could lead creation perfect biomaterial regenerative medicine applications. In this review, we summarize state knowledge regarding possible systems inflammation may influence migration. We also describe forces governing motility a specific focus on ECs. Additionally, discuss EC culture, serve enhance proliferative, proangiogenic, promigratory potential cells. Moreover, introduce mechanisms movement highlight significance understanding these context designing that regeneration.
Language: Английский
Citations
8
Polymer Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 65
Published: Nov. 20, 2024
The biomedical industry has witnessed a transformative evolution with the advent of 3D printing technology. However, inherent limitations, such as inability to produce dynamic human tissues due absence temporal dimension, have persisted, resulting in static and inanimate printed products. To address this challenge enable creation living constructs, concept 4D emerged, marking paradigm shift additive manufacturing. In printing, time becomes fourth breathing life into previously creations. This review paper explores journey from pivotal role manufacturing process. Specifically, it highlights integration time-dependent responsive materials, focusing on stimuli-responsive hydrogels, cornerstone advancements. These materials exhibit remarkable ability adapt respond various stimuli, encompassing physical, chemical, biological signals. delves recent publications synergy between these stimuli shedding light their intricate interactions potential applications. One primary areas interest lies medical applications, notably tissue engineering, where holds immense promise. utilization creating biomimetic scaffolds that can dynamically complex environments. Furthermore, discusses technical considerations prospects technology, emphasizing its revolutionize landscape. amalgamation opens new avenues for personalized medicine, localized drug delivery, regenerative therapies, bridging gap requirements modern healthcare. present offers complete examination evolution, challenges, paving way innovations field.
Language: Английский
Citations
6
ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(5), P. 2251 - 2276
Published: April 10, 2023
Pathological hair loss (also known as alopecia) and shortage of follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation mechanisms in tissue engineering, proliferation HFs vitro has achieved more promising trust treatments alopecia other skin impairments. Theoretically, organoids great potential to develop into native attachments such sweat glands after transplantation. However, since rich extracellular matrix (ECM) deficiency, induction characteristics skin-derived cells gradually fade away along with their trichogenic capacity continuous cell passaging vitro. Therefore, ECM-mimicking support is essential prelude before transplantation implemented. This review summarizes status providing various epidermal dermal a three-dimensional (3D) scaffold homeostasis better mimic vivo environments sake HF-relevant including papilla (DPCs), stem (HFSCs), mesenchymal (MSCs) are able be induced form culture system. The niche microenvironment simulated by different forms biomaterial can offer network ordered growth environment alleviate inductivity promote expression functional proteins. scaffolds often play role ECM substrates bring about epithelial–mesenchymal interaction (EMI) through coculture ensure preservation during passage. Functional formed either or dermis layer. Here, we emphasize importance 3D regeneration Finally, latest progress treatment trials critical analysis properties benefits emerging biomaterials main challenges prospects regenerative approaches discussed.
Language: Английский
Citations
14
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: April 21, 2023
Normal wound healing occurs through a careful orchestration of cytokine and chemokine signaling in response to injury. Chemokines are small family chemotactic cytokines that secreted by immune cells injury primarily responsible for recruiting appropriate cell types injured tissue at the time. Dysregulation is suspected contribute delayed chronic wounds diseased states. Various biomaterials being used development new therapeutics our understanding their effects on limited. It has been shown modifications physiochemical properties can affect body’s reaction. Studying these expression various tissues type help us develop novel biomaterial therapies. In this review, we summarize current research available both natural synthetic healing. investigation, conclude knowledge chemokines still limited many fact share pro-inflammatory anti-inflammatory properties. The predominance either or profile mostly likely dependent timing after exposure biomaterial. More needed better understand interaction contribution activity immunomodulatory effects.
Language: Английский
Citations
13