Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 10206 - 10217

Published: May 15, 2023

Cuproptosis shows good application prospects in tumor therapy. However, the copper efflux mechanism and highly expressed intracellular reducing substances can inhibit cuproptosis effects. In this study, a platelet vesicle (PV) coated cuprous oxide nanoparticle (Cu2O)/TBP-2 sensitization system (PTC) was constructed for multiple induction of cuproptosis. PTC prepared by physical extrusion AIE photosensitizer (TBP-2), Cu2O, PV. After biomimetic modification, enhance its long-term blood circulation targeting ability. Subsequently, rapidly degraded to release ions under acid conditions hydrogen peroxides cells. Then, light irradiation, TBP-2 quickly enters cell membrane generates hydroxyl radicals consume glutathione efflux. Accumulated cause lipoylated protein aggregation iron–sulfur loss, which result proteotoxic stress ultimately treatment target induce cells vitro vivo, significantly lung metastasis breast cancer, increase number central memory T peripheral blood, prevent rechallenge. It provides an idea design nanomedicine based on

Language: Английский

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Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

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A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy

Biomaterials, Journal Year: 2023, Volume and Issue: 295, P. 122034 - 122034

Published: Feb. 1, 2023

Language: Английский

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Self‐Reinforced Bimetallic Mito‐Jammer for Ca²⁺ Overload‐Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature damage‐repair capabilities malignant tumors strongly limit efficacy treatments based on a single treatment mode. To address this challenge, self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) calcium peroxide (CaO 2 ) into hyaluronic (HA) ‐modified metal‐organic frameworks (MOF). After cellular, dissociates CaO Cu 2+ tumor microenvironment. The exposed further yields hydrogen (H O Ca weakly acidic environment to strengthen ‐based Fenton‐like reaction. Furthermore, combination chemodynamic therapy overload exacerbates ROS storms mitochondrial damage, resulting downregulation intracellular adenosine triphosphate (ATP) levels blocking Cu‐ATPase sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic death suppresses metastasis simultaneously. study presents multivariate model for revolutionizing mitochondria relying continuous retention ions boost cuproptosis/immunotherapy cancer.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(20)

Published: March 18, 2023

Abstract The tumor microenvironment (TME) is a complex and variable region characterized by hypoxia, low pH, high redox status, overexpression of enzymes, high‐adenosine triphosphate concentrations. In recent years, with the continuous in‐depth study nanomaterials, more TME‐specific response nanomaterials are used for treatment. However, complexity TME causes different types responses various strategies mechanisms action. Aiming to systematically demonstrate advances in research on TME‐responsive this work summarizes characteristics outlines responses. Representative reaction illustrated their merits demerits analyzed. Finally, forward‐looking views TME‐response presented. It envisaged that such emerging treatment cancer expected exhibit dramatic trans‐clinical capabilities, demonstrating extensive potential diagnosis therapy cancer.

Language: Английский

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The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

Nanoscale, Journal Year: 2023, Volume and Issue: 15(29), P. 12137 - 12156

Published: Jan. 1, 2023

Nanozymes are nanomaterials with catalytic properties similar to those of natural enzymes, and they have recently been collectively identified as a class innovative artificial enzymes.

Language: Английский

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PdCu_x Bimetallic Nanoalloys with “Hand‐in‐Hand” Collaboration in POD‐like Activity and “Back‐to‐Back” Confrontation in SPR Effect for Tumor Redox System Control

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)

Published: Sept. 29, 2023

Abstract In reactive‐oxygen‐species‐mediated tumor therapy, the generation and accumulation of ·OH is highly dependent on peroxidase (POD)‐like enzymatic activities antioxidant microenvironment. As noble metal nanoalloys can enhance POD‐like activity by improving electron transfer upgrading active sites, PdCu x ( = 0.6–1.2) bimetallic with optimized activity, enhanced photothermal conversion efficiency, altered glutathione (GSH) consumption ability are synthesized a facile co‐reduction method. The between Pd Cu in their new + catalytic centers contribute to “hand‐in‐hand” collaboration activities, while properties remain almost unchanged because “back‐to‐back” confrontation occurring owing excess produced surface plasmon resonance effect. Moreover, intrinsic GSH those heat from effect tilt redox steady state. Therefore, 0.9 nanoalloy show excellent resulting route, which involves electron‐enriched hydrogen peroxide heat‐enhanced /Cu 2+ ‐coupled Fenton‐like reactions. shed light mechanism responsible for enhancing offer typical model constructing next‐generation alloy nanozymes.

Language: Английский

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Evoking robust immunogenic cell death by synergistic sonodynamic therapy and glucose depletion using Au clusters/single atoms modified TiO2 nanosheets

Nano Research, Journal Year: 2023, Volume and Issue: 16(7), P. 9730 - 9742

Published: March 10, 2023

Language: Английский

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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.

Language: Английский

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