Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

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Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 9, 2024

Abstract Chemodynamic therapy (CDT) based on intracellular Fenton reaction to produce highly cytotoxic reactive oxygen species (ROS) has played an essential role in tumor therapy. However, this still needs be improved by weakly acidic pH and over-expression of glutathione (GSH) microenvironment (TEM), which hinders its future application. Herein, we reported a multifunctional bimetallic composite nanoparticle MnO 2 @GA-Fe@CAI metal polyphenol network (MPN) structure, could reduce endogenous GSH remodeling improve activity. nanoparticles were prepared first @GA-Fe with Fe 3+ as central ion gallic acid (GA) surface ligands the chelation reaction. Then, carbonic anhydrase inhibitor (CAI) was coupled GA form @GA-Fe@CAI. The properties studied, results showed that CAI pH. At same time, deplete Mn 2+ via redox reactions, re-established TME low GSH. In addition, reduced . catalyzed H O high-lever ROS kill cells. Compared , weight volume for xenograft MDA-MB-231 tumor-bearing mice final inhibition rate 58.09 ± 5.77%, showing therapeutic effect well biological safety. Therefore, study achieved high-efficiency CDT through reshaping microenvironment. Graphical

Language: Английский

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Oxidative Damage as a Fundament of Systemic Toxicities Induced by Cisplatin—The Crucial Limitation or Potential Therapeutic Target?

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14574 - 14574

Published: Sept. 26, 2023

Cisplatin, an inorganic complex of platinum, is a chemotherapeutic drug that has been used for 45 years. Despite the progress pharmaceutical sciences and medicine successful application other platinum complexes same purpose, cisplatin still therapy choice in many cancers. Treatment testicular, ovarian, head neck, urothelial, cervical, esophageal, breast, pulmonary malignancies unthinkable without use this drug. However, also known side effects, which most pronounced are nephrotoxicity leading to acute renal failure, neurotoxicity, ototoxicity. Mechanistic studies have proven one conditions plays major role development cisplatin-induced toxicities oxidative stress. Knowing fact numerous antioxidants can be reduce stress, thereby reducing tissue lesions, organ apoptosis at cellular level, defined as priority investigation cotreatment. To investigate mechanism antioxidant action vivo, animal models employed. In last few years, mostly rodents zebrafish models. article, some recent investigations listed, advantages disadvantages such experimental pointed out.

Language: Английский

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Designing Peptide-Based Nanoinhibitors of Programmed Cell Death Ligand 1 (PD-L1) for Enhanced Chemo-immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1690 - 1701

Published: Jan. 2, 2024

The combination of immune checkpoint blockade (ICB) and chemotherapy has shown significant potential in the clinical treatment various cancers. However, circulating regeneration PD-L1 within tumor cells greatly limits efficiency chemo-immunotherapy consequent patient response rates. Herein, we report synthesis a nanoparticle-based inhibitor (FRS) with rational design for effective endogenous suppression. nanoinhibitor is achieved through self-assembly fluoroalkylated competitive peptides that target palmitoylation. FRS nanoparticles provide efficient protection delivery functional to cytoplasm tumors, showing greater inhibition than nonfluorinated peptidic inhibitors. Moreover, demonstrate synergizes chemotherapeutic doxorubicin (DOX) boost antitumor activities via simultaneous reduction abundance induction immunogenic cell death murine colon models. nano strategy regulation present this study expected advance development ICB inhibitors overcome limitations conventional ICB-assisted chemo-immunotherapy.

Language: Английский

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A cascade nanoplatform for intelligent response to tumor microenvironment and collaborative cancer therapy

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(10), P. 2537 - 2546

Published: Jan. 1, 2024

The DCZCu nanoplatform provides a powerful multimodal synergistic anticancer strategy for tumor growth inhibition in terms of enhanced chemotherapy.

Language: Английский

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Controllable Synthesis of Self-Assembled Nitroimidazole-Based Nanocomplexes for Enhanced Chemodynamic Therapy by Dual-Channel Modulation of Glutathione

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2165 - 2173

Published: May 3, 2024

Chemodynamic therapy (CDT) offers an effective in situ activation for cancer treatments. However, the efficiency of CDT is limited by antioxidant system within tumor cells, including antioxidative niacinamide adenine dinucleotide phosphate (NADPH) and glutathione (GSH). Zeolitic imidazolate framework-8 (ZIF-8) widely used therapies due to its tunable structure properties, but ZIF-8 itself lacks application. In order meet application demand CDT, we select Cu2+ ions that can catalyze a Fenton-like reaction 2-nitroimidazole (2-NI) consume NADPH as new inorganic–organic connection components. Based on reasonable coordination mode ZIF-8, nanoplatform with adjustable size constructed. The synthesized Cu-NI NPs are triple responsive hypoxia, GSH, hydrogen peroxide (H2O2), which selectively enhance Cu+/Cu2+-mediated induce apoptosis/ferroptosis. This work will promote diversification structures provide good implications realization enhanced CDT.

Language: Английский

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Tumor therapy utilizing dual-responsive nanoparticles: A multifaceted approach integrating calcium-overload and PTT/CDT/chemotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 646 - 658

Published: Oct. 25, 2024

Language: Английский

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Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139535 - 139535

Published: Jan. 5, 2025

Language: Английский

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Mitochondria-targeted H2O2 homeostatic disruptors: Harnessing glutathione autoxidation and reversing GSDME “silencing” for ferroptotic and dual-pathway pyroptotic oncotherapy

Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102640 - 102640

Published: Jan. 14, 2025

Language: Английский

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Reactive Oxygen Species Amplifier Based on Bi2WO6/BP Heterojunction for High Efficiency Radiotherapy Enhancement

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Insufficient reactive oxygen species (ROS) generation and radioresistance resulting from the intrinsic features of tumors consistently give rise to unsatisfactory therapeutic outcomes radiotherapy (RT).

Language: Английский

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