Published: Nov. 15, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)
Published: Feb. 14, 2024
Abstract Microfluidic chips play crucial roles while lack satisfactory controllability and comprehensive functionality. Inspired by biological systems, this study proposes a method utilizing rolling microneedles (RMNs) to generate muti‐structured templates, realizing photonic crystal membrane (PC) based meta microfluidic microneedle chip (MMM) for efficient wound management. This approach offers advantages in terms of speed cost‐effectiveness, achieving dual‐sided permeation patterned design directly RMNs at desired locations, serving as both template tools fabrication. The integration with PC results the 3D multilayer channels, effectively addressing issues related spontaneous fluid flow. As reaches membrane, it generates distinctive structural colors exhibits fluorescence enhancement, enabling monitoring inflammatory factors mouse wounds facilitating In summary, preparation involving paves way control chips. bioinspired patch holds significant potential not only management but also areas such clinical drug delivery point‐of‐care testing (POCT).
Language: Английский
Citations
24
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 300 - 300
Published: Feb. 21, 2024
Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.
Language: Английский
Citations
23
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)
Published: July 20, 2023
Abstract The discovery of antibiotics has saved millions lives, but the emergence antibiotic‐resistant bacteria become another problem in modern medicine. To avoid or reduce overuse antibacterial treatments, stimuli‐responsive materials, pathogen‐targeting nanoparticles, immunogenic nano‐toxoids, and biomimetic materials are being developed to make sterilization better smarter than conventional therapies. common goal smart (SAMs) is increase antibiotic efficacy function via an mechanism different from that order biological properties while reducing risk drug resistance. research development SAMs increasingly interdisciplinary because new designs require knowledge fields input/collaboration scientists fields. A good understanding energy conversion physiological characteristics cells bacteria, bactericidal structures components nature expected promote SAMs. In this review, importance multidisciplinary insights for emphasized, latest advances categorized discussed according pertinent disciplines including science, physiology, biomimicry.
Language: Английский
Citations
38
npj Flexible Electronics, Journal Year: 2024, Volume and Issue: 8(1)
Published: May 11, 2024
Abstract Wound infection is a worldwide health issue that not only brings large detrimental effects to people’s physical and mental health, but also causes substantial economic burdens society. By using traditional surgical debridement antibiotic therapy, patients generally suffer more pain are at risk of recurring infections. Thus, the development non-antibiotic treatment methods desperately needed. Currently, emerging flexible wound dressings with physiological signal detection, inactivated infectious pathogen, wound-healing promoting properties has exhibited immense potential for infected wound. Among various dressings, MXene‐based electronic materials as special electroactive, mechanical, photophysical, biological performances possess broad application prospect in healthcare. In this review, challenges management introduced. Next, types MXene-based features outlined. Then recent advance detection summarized. Lastly, predicaments, prospects, future directions discussed.
Language: Английский
Citations
12
Small, Journal Year: 2023, Volume and Issue: 20(12)
Published: Nov. 8, 2023
Abstract The treatment of chronic wounds still presents great challenges due to being infected by biofilms and the damaged healing process. current treatments do not address needs wounds. In this study, a highly effective dressing (Dox‐DFO@MN Hy) for is described. This combines advantages microneedles (MNs) hydrogels in MNs employed debride break down wound barrier, providing rapid access therapeutic drugs from hydrogel backing layer. Importantly, kill pathogenic bacteria specifically, Doxycycline hydrochloride (Dox) wrapped into polycaprolactone (PCL) microspheres that have lipase‐responsive properties loaded tips MNs. At same time, layer used seal accelerate healing. Benefiting combination two hydrogel, significantly reduces effectively promotes angiogenesis cell migration vitro. Overall, Dox‐DFO@MN Hy can treat with biofilms, new idea
Language: Английский
Citations
16
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8407 - 8423
Published: April 4, 2024
Triboelectric nanogenerators (TENGs) developed from eco-friendly natural materials rather than traditional electronic are more favorable for biocompatible applications and use in sustainable life-cycle analysis. Silk fibroin (SF) has emerged as an abundant biomaterial that shows great potential the preparation of TENGs. Silk-based triboelectric (SF-TENGs) have green energy harvesting properties, environmentally friendly, biocompatible, not fully present conventional TENGs, important next generation self-powered devices. In this review, latest progress SF-TENGs, including their applied materials, structural manufacturing processes, application scenarios, is discussed. These SF-TENGs show emerging well smart living medical assistance. addition, value been further explored, possibility main challenges expanding applying to field microneedles (MNs)
Language: Английский
Citations
7
Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(14), P. 3513 - 3532
Published: Jan. 1, 2024
Recent advancements in MXene-based wound dressings are discussed, focusing on their contributions to tissue regeneration, infection control, anti-inflammation and photothermal effects, targeted therapeutic delivery.
Language: Английский
Citations
7
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124247 - 124247
Published: May 22, 2024
Language: Английский
Citations
7
Small, Journal Year: 2023, Volume and Issue: 20(18)
Published: Dec. 1, 2023
Abstract Wounds and the subsequent formation of scars constitute a unified complex phased process. Effective treatment is crucial; however, diverse therapeutic approaches for different wounds scars, as well varying needs at stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), novel minimally invasive transdermal drug delivery system, has potential integrated programmed various diseases shown promising applications types scars. In this comprehensive review, latest biotechnological innovations MNPs these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, manage related symptoms. Moreover, scenarios discussed. Additionally, side effects, manufacturing processes, material selection explore clinical translational investigated. This groundwork can provide theoretical basis serve catalyst future pursuit favorable options skin tissue regeneration.
Language: Английский
Citations
15
RSC Advances, Journal Year: 2024, Volume and Issue: 14(17), P. 11643 - 11658
Published: Jan. 1, 2024
Many ordered arrangements are observable in the natural world, serving not only as pleasing aesthetics but also functional improvements.
Language: Английский
Citations
5