Published: Jan. 1, 2024
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Language: Английский
ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(11), P. 6581 - 6593
Published: May 24, 2024
Photodynamic therapy (PDT) presented tremendous potential for combating implant-related infections, but its antibacterial efficacy was constrained by rapid electron–hole pair recombination of photosensitizers and barrier action a dense biofilm on reactive oxygen species (ROS). Herein, cascade phototherapeutic AuKN-LA nanosystem constructed depositing Au nanoparticles l-arginine (LA) potassium niobate (KN) photosensitizer. In the nanosystem, with lower Fermi levels could capture photogenerated electrons thus suppress to enhance ROS generation. Especifically, trigger generated release nitric oxide (NO) destroy biofilm, thereby facilitating entry ROS. Furthermore, NO itself possessed activity, which form synergy PDT. Then, introduced into poly(l-lactic acid) scaffolds fabricated laser additive manufacturing. Photoelectrochemical analysis proved that separation improved, significantly increasing detection crystal violet staining showed effectively remove sustainably releasing under light irradiation. As consequence, exhibited excellent rates 98.7% 99.2% against E. coli S. aureus, respectively, disrupting bacterial cell membranes causing leakage nucleic acid molecules proteins.
Language: Английский
Citations
28
Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 414 - 421
Published: Jan. 10, 2024
Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive tumor microenvironment (TME) enhance PDT through glutathione (GSH) depletion. Our approach aims expand sources therapeutic benefits by promoting generation superoxide radicals (O
Language: Английский
Citations
19
Small, Journal Year: 2024, Volume and Issue: 20(35)
Published: April 23, 2024
Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles tumor diagnosis treatment lie their ability to target delivery, minimizing toxicity normal tissues while enhancing therapeutic efficacy. Moreover, responsiveness both endogenous exogenous stimuli opens up new possibilities integrating multiple modalities. This review scrutinizes the burgeoning utility combination with chemotherapy other Commencing elucidation synthesis degradation mechanisms, emphasis placed on these materials (e.g., pH, redox reactions, hypoxia, enzymes) light high-intensity focused ultrasound). this exploration delves into strategies harnessing alone, coupled radiotherapy, photothermal therapy, photodynamic gas immunotherapy, starvation chemodynamic elucidating multimodal synergies. Concluding an assessment advances, challenges, constraints oncology, despite hurdles, future investigations are anticipated augment role cancer therapy. These insights can serve a compass devising more efficacious combined strategies.
Language: Английский
Citations
11
ACS Omega, Journal Year: 2024, Volume and Issue: 9(14), P. 16676 - 16686
Published: April 1, 2024
Oxaliplatin (Oxa) is a commonly used chemotherapy drug in the treatment of gastric cancer, but its toxic side effects and resistance after long-term use have seriously limited efficacy. Loading drugs with nanomaterials delivering them to tumor site are common ways overcome above problems. However, as carriers do not therapeutic functions on their own, effect single relatively limited, so there still room for progress related research. Herein, we construct Oxa@Mil-100(Fe) nanocomposites by loading Oxa metal–organic framework (MOF) Mil-100(Fe) high biocompatibility large specific surface area. The pore structure conducive amount drug-loading rate up 27.2%. responsive microenvironment (TME) can release Fe3+ under external stimulation. On one hand, inhibit synthesis DNA induce apoptosis cancer cells. other clear overexpressed glutathione (GSH) TME be reduced Fe2+, inhibiting activity peroxidase 4 (GPX4), leading accumulation intracellular lipid peroxides (LPO), at same time releasing number reactive oxygen species (ROS) through Fenton reaction, inducing ferroptosis With combination ferroptosis, shows good effect, killing cells obvious. In nude mouse model subcutaneous transplantation, significant inhibitory growth, an inhibition nearly 60%. addition excellent antitumor activity, has no obvious or effects. This study provides new idea method combined cancer.
Language: Английский
Citations
9
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Microelectrodes offer exceptional sensitivity, rapid response, and versatility, making them ideal for real-time detection monitoring applications. Photoelectrochemical (PEC) sensors have shown great value in many fields due to their high fast ease of operation. Nevertheless, conventional PEC sensing relies on cumbersome external light sources bulky electrodes, hindering its miniaturization implantation, thereby limiting application disease monitoring. To overcome these limitations, we developed a nanoencapsulated optical fiber (OF)-based microelectrode. The microelectrode features TiO2/CdS nanocrystals bis (2,2′-bipyridine) (10-methylphenanthroline [3,2-a:2′3′-c] pyridine ruthenium(II) dichloride ([Ru(bpy)2dppz]2+) @dsDNA/Au@epigallocatechin gallate nanoparticle (EGCG NP) layers. And the N-terminal pro-brain natriuretic peptide (NT-proBNP) as biomarker cardiovascular diseases was explored. An extensive linear range 1–5000 pg mL–1 combined with low limit 0.36 achieved. This covers not only recommended threshold excluding clinical diagnosis individuals across all age groups but also prognostic target value. sensor exhibited excellent selectivity stability notable labeling recovery capability serum tests. Critically, successfully discriminated alterations NT-proBNP secretion levels within human smooth muscle cells, comparing pre- poststimulation by platelet-derived growth factor-BB. Even more significantly, skin puncture experiment conducted mice demonstrated remarkable implantability biological compatibility OF-PEC addresses critical challenges commonly faced microelectrodes when used implanted devices, such minimizing invasive trauma, mitigating inflammation, preventing biofouling, firmly establishing suitability development advanced implantable devices. Therefore, present OF biosensor is cost-effective, easy operate, miniaturized holds significant potential enabling precise, minimally invasive, continuous markers without causing inflammation. crucial early detection, tracking progression, facilitating personalized treatment strategies, which expands practical sensors.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152755 - 152755
Published: June 1, 2024
Language: Английский
Citations
6
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 174, P. 91 - 103
Published: Dec. 11, 2023
Language: Английский
Citations
14
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality biomedical application. Herein, multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed highly efficient antitumor therapy, which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified NO donor (RuNO) folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), NPs co-liberated DTC Cu2+ site, where formation cytotoxic Cu(DTC)2 complex effectively killed cells. Furthermore, under near-infrared (NIR) light irradiation, could deliver nitric oxide (NO) produce superoxide anions (O2•-), followed more toxic peroxynitrite (ONOO-), led to promoted cell apoptosis. 1064 nm NIR vivo experiments demonstrated an impressively high inhibition rate (∼97%) while good biocompatibility. This work activated approach precision medicine that might imply its potential clinical applications.
Language: Английский
Citations
0
Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1871 - 1871
Published: June 30, 2024
Polyion complex (PIC) nanoparticles, including PIC micelles and PICsomes, are typically composed of poly(ethylene glycol) block copolymers coupled with oppositely charged polyelectrolytes or therapeutic agents via electrostatic interaction. Due to a simple rapid preparation process high drug-loading efficiency, nanoparticles beneficial maintaining the chemical integrity biological activity loaded drugs. However, stability can be disrupted in high-ionic-strength solutions because interaction is DRIVING force; these disruptions thus impair drug delivery. Herein, we summarize advances use for delivery drugs, focusing on different physical strategies employed enhance their stability, enhancing charge density, crosslinking, increasing hydrophobic interactions, forming hydrogen bonds, development PIC-based gels. In particular, describe load peptide antibiotics targeting antibiotic-resistant biofilm-related diseases that chemotherapeutics gaseous donors cancer treatment. Furthermore, application as magnetic resonance imaging contrast summarized first time. Therefore, this review great significance polymeric functional
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 4, 2024
Gas therapy has emerged as a promising approach for treating cancer, with gases like NO, H2S, and CO showing positive effects. Among these, NO is considered key gas molecule significant potential in stopping cancer progression. However, due to its high reactivity short half-life, delivering directly tumors crucial enhancing treatment. NO-driven nanomedicines (NONs) have been developed effectively deliver donors tumors, great progress recent years. This review provides an overview of the latest advancements NO-based nanotherapeutics. It discusses types used current research, mechanisms action behind different delivery systems also explores combining other treatments enhanced therapy. Finally, it examines future prospects challenges using NONs clinical settings
Language: Английский
Citations
2