Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment

Theranostics, Journal Year: 2019, Volume and Issue: 9(26), P. 8073 - 8090

Published: Jan. 1, 2019

The use of nanomedicine for cancer treatment takes advantage its preferential accumulation in tumors owing to the enhanced permeability and retention (EPR) effect.The development has promised highly effective options unprecedented by standard therapeutics.However, therapeutic efficacy passively targeted is not always satisfactory because it largely influenced heterogeneity intensity EPR effect exhibited within a tumor, at different stages among individual tumors.In addition, limited data on effectiveness human hinders further clinical translation nanomedicine.This unsatisfactory outcome mice humans necessitates novel approaches improve effect.This review focuses current attempts overcoming limitations traditional EPR-dependent incorporating supplementary strategies, such as additional molecular targeting, physical alteration, or physiological remodeling tumor microenvironment.This will provide valuable insight researchers who seek overcome relying alone go "beyond effect".

Language: Английский

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Tumor-Targeted Cascade Nanoreactor Based on Metal–Organic Frameworks for Synergistic Ferroptosis–Starvation Anticancer Therapy

ACS Nano, Journal Year: 2020, Volume and Issue: 14(9), P. 11017 - 11028

Published: Aug. 13, 2020

Although ferroptosis therapy has been proven to be a promising strategy for cancer treatment, its efficacy still might limited by insufficient H2O2 supply in tumor tissue. Herein, we designed cell membrane-cloaked cascade nanoreactor based on ferric metal–organic frameworks (MOF) and glucose oxidase (GOx) decoration synergistic ferroptosis–starvation anticancer therapy. The GOx can catalyze generate sufficient therapy, the consumption caused utilized as another attractive treatment called starvation When reached sites, high concentration of GSH reduced Fe3+ trigger structure collapse MOF release Fe2+ catalyzed oxidation H2O2. Then Fenton reaction happened between produce hydroxyl radicals (•OH) promoted With these reactions, was realized. Furthermore, membrane endows homologous targeting immune escaping ability, which facilitated accumulate into site with efficiency. exhibits efficiency suppression situ consumed produced compounds, promote development precise cooperative spatiotemporal controllability.

Language: Английский

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Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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Transformable Nanosensitizer with Tumor Microenvironment‐Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(25), P. 14051 - 14059

Published: April 2, 2021

Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces mitochondrial dysfunction via overloading intracellular ions synergize with process TME. substantially enhances immunogenic cell death, resulting enhanced T‐cell recruitment infiltration into cold (4T1). In conjunction checkpoint blockade therapy (anti‐PD 1), @CaP‐mediated elicits systemic antitumor immunity, regression non‐treated distant tumors inhibition lung metastasis. This work paves way development “smart” TME‐activatable temporospatial control over responses.

Language: Английский

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A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy

Advanced Science, Journal Year: 2020, Volume and Issue: 7(17)

Published: June 14, 2020

The incorporation of new modalities into chemotherapy greatly enhances the anticancer efficacy combining merits each treatment, showing promising potentials in clinical translations. Herein, a hybrid nanomedicine (Au/FeMOF@CPT NPs) is fabricated using metal-organic framework (MOF) nanoparticles and gold (Au as building blocks for cancer chemo/chemodynamic therapy. MOF NPs are used vehicles to encapsulate camptothecin (CPT), hybridization by Au improves stability physiological environment. Triggered high concentration phosphate inside cells, Au/FeMOF@CPT effectively collapse after internalization, resulting complete drug release activation cascade catalytic reactions. intracellular glucose can be oxidized produce hydrogen dioxide, which further utilized chemical fuel Fenton reaction, thus realizing synergistic efficacy. Benefitting from enhanced permeability retention effect sophisticated fabrications, blood circulation time tumor accumulation significantly increased. In vivo results demonstrate that combination chemodynamic therapy suppresses growth, meantime systemic toxicity this avoided.

Language: Английский

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Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 143(2), P. 538 - 559

Published: Dec. 28, 2020

The past few decades have witnessed an evolution of nanomedicine from biologically inert entities to more smart systems, aimed at advancing in vivo functionality. However, we should recognize that most systems still rely on reasonable explanation-including some over-explanation-rather than definitive evidence, which is a watershed radically determining the speed and extent nanomedicine. Probing nano-bio interactions desirable functionality tissue, cellular, molecular levels frequently overlooked. Progress toward answering these questions will provide instructive insight guiding effective chemo-physical strategies. Thus, next generation, argue much effort be made evidence for proof-of-mechanism, lieu creating many new complicated similar proof-of-concept.

Language: Английский

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Strategies for enhancing cancer chemodynamic therapy performance

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

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Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration

Small, Journal Year: 2020, Volume and Issue: 16(20)

Published: April 24, 2020

Antioxidant nanoparticles have recently gained tremendous attention for their enormous potential in biomedicine. However, discrepant reports of either medical benefits or toxicity, and lack reproducibility many studies, generate uncertainties delaying effective implementation. Herein, the case cerium oxide is considered, a well-known catalyst petrochemistry industry one first antioxidant proposed medicine. Like other nanoparticles, it now described as promising therapeutic alternative, threatening to health. Sources these discrepancies how this analysis helps overcome contradictions found are summarized discussed. For context analysis, what has been reported liver reviewed, where diseases related oxidative stress. Since well-dispersed passively accumulate liver, represents major testing field study new nanomedicines clinical translation. Even more, contradictory works cerium-oxide-associated toxicity protection against stress inflammation. Based on this, finally, intention propose solutions design improved that will work more precisely medicine safely society.

Language: Английский

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Small‐Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery

Small, Journal Year: 2021, Volume and Issue: 17(52)

Published: Aug. 3, 2021

The antitumor efficiency and clinical translation of traditional nanomedicines is mainly restricted by low drug loading, complex preparation technology, potential toxicity caused the overused carrier materials. In recent decades, small-molecule prodrug nanoassemblies (SMP-NAs), which are formed self-assembly prodrugs themselves, have been widely investigated with distinct advantages ultrahigh drug-loading negligible excipients-trigged adverse reaction. Benefited from simple process, SMP-NAs used for chemotherapy, phototherapy, immunotherapy, tumor diagnosis. addition, combination therapy based on accurate co-delivery behavior can effectively address challenges heterogeneity multidrug resistance. Recent trends in outlined, corresponding mechanisms discussed detail. Besides, smart stimuli-responsive summarized, special emphasis structure-function relationships. Finally, outlooks cancer highlighted.

Language: Английский

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Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(24), P. 9057 - 9094

Published: Jan. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Language: Английский

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