Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications DOI Open Access
Domenico Lombardo, Pietro Calandra, Luigi Pasqua

et al.

Materials, Journal Year: 2020, Volume and Issue: 13(5), P. 1048 - 1048

Published: Feb. 26, 2020

In this paper, we survey recent advances in the self-assembly processes of novel functional platforms for nanomaterials and biomaterials applications. We provide an organized overview, by analyzing main factors that influence formation organic nanostructured systems, while putting into evidence challenges, limitations emerging approaches various fields nanotechology biotechnology. outline how building blocks properties, mutual cooperative interactions, as well initial spatial configuration (and environment conditions) play a fundamental role construction efficient materials with desired properties. The insertion endgroups (such polymers, peptides or DNA) within units has enormously increased complexity morphologies functions can be designed fabrication bio-inspired capable mimicking biological activity. However, unwanted uncontrollable effects originating from unexpected thermodynamic perturbations complex interactions interfere at molecular level assembly process. Correction harmonization is one major challenges next decades requires deeper knowledge understanding key drive nanomaterials. Self-assembly still remains central topic current research located interface between material science engineering, biotechnology nanomedicine, it will continue to stimulate renewed interest biologist, physicists engineers combining principles concept supramolecular chemistry.

Language: Английский

Natural Fiber-Reinforced Polylactic Acid, Polylactic Acid Blends and Their Composites for Advanced Applications DOI Open Access
R.A. Ilyas, M.Y.M. Zuhri,

H. A. Aisyah

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(1), P. 202 - 202

Published: Jan. 5, 2022

Polylactic acid (PLA) is a thermoplastic polymer produced from lactic that has been chiefly utilized in biodegradable material and as composite matrix material. PLA prominent biomaterial widely used to replace traditional petrochemical-based polymers various applications owing environmental concerns. Green composites have gained greater attention ecological consciousness grown since they the potential be more appealing than conventional petroleum-based composites, which are toxic nonbiodegradable. PLA-based with natural fiber extensively variety of applications, packaging medicine, due their biodegradable, recyclable, high mechanical strength, low toxicity, good barrier properties, friendly processing, excellent characteristics. A summary fibers, green PLA, along respective classification, functionality, different processing methods, discussed discover fiber-reinforced development for wide range applications. This work also emphasizes research properties blend hybrid over past few years. PLA's strong engineering areas addressed. review covers issues, challenges, opportunities, perspectives developing characterizing composites.

Language: Английский

Citations

255
Biopolymers and composites: Properties, characterization and their applications in food, medical and pharmaceutical industries DOI

Gowthama Prabu Udayakumar,

Subbulakshmi Muthusamy,

Bharathi Selvaganesh

et al.

Journal of environmental chemical engineering, Journal Year: 2021, Volume and Issue: 9(4), P. 105322 - 105322

Published: March 19, 2021

Language: Английский

Citations

244
Systemic Review of Biodegradable Nanomaterials in Nanomedicine DOI Creative Commons
Shi Su, Peter M. Kang

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(4), P. 656 - 656

Published: April 1, 2020

Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment human disease. It has emerged as an important aspect therapeutics, but at same time, also raises concerns regarding safety nanomaterials involved. Recent applications functionalized biodegradable have significantly improved profile nanomedicine.

Language: Английский

Citations

237
Nanoparticle-Based Dressing: The Future of Wound Treatment? DOI

Morgane Berthet,

Yves Gauthier, Céline Lacroix

et al.

Trends in biotechnology, Journal Year: 2017, Volume and Issue: 35(8), P. 770 - 784

Published: June 21, 2017

Language: Английский

Citations

230
The Blood Clearance Kinetics and Pathway of Polymeric Micelles in Cancer Drug Delivery DOI
Xuanrong Sun, Guowei Wang, Hao Zhang

et al.

ACS Nano, Journal Year: 2018, Volume and Issue: 12(6), P. 6179 - 6192

Published: May 30, 2018

Polymer micelles are one of the most investigated nanocarriers for drug delivery; many have entered clinical trials and some in clinic use, but their delivery systems not yet shown expected high therapeutic efficacy clinics. Further understanding vivo behaviors, particularly how quickly by what mechanism polymer cleared (i.e., via or unimers) once injected, is key to solving this dilemma. Herein, we hope answer these questions clinically relevant polyethylene glycol-block-poly(ε-caprolactone) (PEG-PCL) PEG-block-poly(d,l-lactide) (PEG-PDLLA) micelles. A small fraction hydrophobic chain ends was conjugated with a pair fluorescence resonance energy transfer (FRET) dyes, Cy5 Cy5.5, used fabricate FRET whose efficiency correlated percentage chains micelles, micelle degree. In vitro, serum proteins induced PEG-PCL dissociation extent; mouse blood surprisingly did induce shear applied microfluidic channel caused dissociated. After intravenous administration mice, PEG-PDLLA were sequestered into liver as unimers, degree decreased about 20%. The FRET-imaging experiments showed that vessels dissociated which found associated albumin liver. Thus, it concluded that, upon injection, bloodborne (particularly albumin) (∼80%) dissociate Kupffer cells, while intact difficult clear. These able penetrate tumors very stable cell membranes, gradually inside cells. findings on fate clearance directional rational design improved therapeutics; particularly, improving stability prerequisite surface functionalizations such introducing targeting ligands.

Language: Английский

Citations

219
Recent advances in biomedical engineering of nano-hydroxyapatite including dentistry, cancer treatment and bone repair DOI
Mingzu Du, Jingdi Chen, Kaihua Liu

et al.

Composites Part B Engineering, Journal Year: 2021, Volume and Issue: 215, P. 108790 - 108790

Published: March 18, 2021

Language: Английский

Citations

219
A Micro‐Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration DOI
Dai‐Xu Wei, Jin‐Wei Dao, Guo‐Qiang Chen

et al.

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(31)

Published: June 19, 2018

To avoid large open surgery using scaffold transplants, small-sized cell carriers are employed to repair complexly shaped tissue defects. However, most show poor adherences and viability. Therefore, polyhydroxyalkanoate (PHA), a natural biopolymer, is used prepare highly porous microspheres (OPMs) of 300-360 µm in diameter, combining the advantages scaffolds serve as injectable harboring proliferating stem cells. In addition convenient injection defected tissue, contrast performances OPMs made polylactides (PLA OPMs) traditional less hollow (PHA HMs), PHA present suitable surface pores 10-60 interconnected passages with an average size 8.8 µm, leading high vitro adhesion 93.4%, continuous proliferation for 10 d improved differentiation human bone marrow mesenchymal cells (hMSCs). also support stronger osteoblast-regeneration compared HMs, PLA OPMs, commercial hyaluronic acid hydrogels, carrier-free hMSCs ectopic bone-formation mouse model. protect against stresses during injection, allowing more living proliferate migrate damaged tissues. They function like micro-Noah's Ark safely transport defect tissue.

Language: Английский

Citations

212
Synthesis and characterization of curcumin loaded PLA—Hyperbranched polyglycerol electrospun blend for wound dressing applications DOI
Govindaraj Perumal, Sreenath Pappuru, Debashis Chakraborty

et al.

Materials Science and Engineering C, Journal Year: 2017, Volume and Issue: 76, P. 1196 - 1204

Published: March 23, 2017

Language: Английский

Citations

181
4D printing of shape memory polylactic acid (PLA) DOI Creative Commons
Mehrshad Mehrpouya, Henri Vahabi, Shahram Janbaz

et al.

Polymer, Journal Year: 2021, Volume and Issue: 230, P. 124080 - 124080

Published: Aug. 9, 2021

Additive manufacturing has attracted much attention in the last decade as a principal growing sector of complex manufacturing. Precise layer-by-layer patterning materials gives rise to novel designs and fabrication strategies that were previously not possible realize with conventional techniques. Using suitable organized variation printing settings, parts time-dependent shapes can be tuned through environmental stimuli realized. Given these either change their shape over time pre-programmed three-dimensional or revert an initial design, this process become referred four-dimensional (4D) printing. In regard, commonly-used polylactic acid (PLA) polymer been recognized compelling material candidate for 4D it is biobased great memory behavior employed design broad range smart products. review, we investigate properties PLA first section. Then, discuss potential printing, including principles underlying strategy PLA-based self-folding structures. The resulting exhibit response stimulus well temperature, magnetic field, light. We additionally impact geometrical conditions on functionality final printed

Language: Английский

Citations

181
Recent Advances in 3D Printing of Aliphatic Polyesters DOI Creative Commons
Ioana Chiulan, Adriana Nicoleta Frone,

Călin Brandabur

et al.

Bioengineering, Journal Year: 2017, Volume and Issue: 5(1), P. 2 - 2

Published: Dec. 24, 2017

3D printing represents a valuable alternative to traditional processing methods, clearly demonstrated by the promising results obtained in manufacture of various products, such as scaffolds for regenerative medicine, artificial tissues and organs, electronics, components automotive industry, art objects so on. This revolutionary technique showed unique capabilities fabricating complex structures, with precisely controlled physical characteristics, facile tunable mechanical properties, biological functionality easily customizable architecture. In this paper, we provide an overview main 3D-printing technologies currently employed case poly (lactic acid) (PLA) polyhydroxyalkanoates (PHA), two most important classes thermoplastic aliphatic polyesters. Moreover, short presentation methods is briefly discussed. Both PLA PHA, form filaments or powder, proved be suitable fabrication tissue bone regeneration. The processability PHB blends composites fabricated through different techniques, their final characteristics targeted applications bioengineering are thoroughly reviewed.

Language: Английский

Citations

171