Recent advances on antimicrobial wound dressing: A review

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2018, Volume and Issue: 127, P. 130 - 141

Published: Feb. 17, 2018

Language: Английский

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Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(5)

Published: Jan. 24, 2020

Abstract The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder wound microenvironment. Although numerous strategies bioactive hydrogels are developed, an effective widely used method remains bottleneck. With aim accelerate healing, many hydrogel dressings with antioxidant functions have emerged proven especially for repair. new strategy in brought by is great significance human health. Here, application repair discussed systematically, aiming provide important theoretical reference further breakthrough healing.

Language: Английский

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PLGA-Based Nanoparticles in Cancer Treatment

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Nov. 2, 2018

Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently in such setups. This review article gives an overview the properties previously reported PLGA nanoparticles (NPs), their behavior biological systems, use Strategies emphasized to target NPs tumor site passively actively. Furthermore, combination introduced that enhance accumulation and, thereby, therapeutic efficacy. In this context, huge number reports on as delivery systems treatment highlight potential carriers therapeutics encourage further translational research.

Language: Английский

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Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Frontiers in Bioengineering and Biotechnology, Journal Year: 2019, Volume and Issue: 7

Published: May 24, 2019

Advances in nanoparticle (NP) production and demand for control over nanoscale systems have had significant impact on tissue engineering regenerative medicine (TERM). NPs with low toxicity, contrasting agent properties, tailorable characteristics, targeted/stimuli-response delivery potential, precise behavior (via external stimuli such as magnetic fields) made it possible their use improving engineered tissues overcoming obstacles TERM. Functional organ replacements require a high degree of spatial temporal the biological events also real-time monitoring. Presentation local bioactive (growth factors, chemokines, inhibitors, cytokines, genes etc.) contrast agents controlled manner are important implements to exert monitor tissues. This need resulted utilization NP based scaffolds multiple growth providing imaging controlling properties scaffolds. Depending application, materials, polymers, metals, ceramics different composites can be utilized NPs. In this review, we will cover TERM provide an outlook future potential systems.

Language: Английский

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Recent advances in inorganic nanomaterials for wound-healing applications

Biomaterials Science, Journal Year: 2019, Volume and Issue: 7(7), P. 2652 - 2674

Published: Jan. 1, 2019

The emergence of inorganic nanoparticles has generated considerable expectation for solving various biomedical issues including wound healing and tissue regeneration. This review article highlights the role recent advancements regeneration along with their advantages, clinical status, challenges future directions.

Language: Английский

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Wound dressings functionalized with silver nanoparticles: promises and pitfalls

Nanoscale, Journal Year: 2019, Volume and Issue: 12(4), P. 2268 - 2291

Published: Dec. 13, 2019

Infections are the main reason why most people die from burns and diabetic wounds. The clinical challenge for treating wound infections through traditional antibiotics has been growing steadily now reached a critical status requiring paradigm shift improved chronic care. US Centers Disease Control have predicted more deaths antimicrobial-resistant bacteria than all types of cancers combined by 2050. Thus, development new dressing materials that do not rely on is paramount importance. Currently, incorporating nanoparticles into scaffolds represents concept 'nanoparticle dressing' which gained considerable attention healing. Silver (Ag-NPs) categorized as metal-based intriguing healing because their excellent antimicrobial properties. Ag-NPs embedded in polymers promote control microorganism growth. However, there several recent disadvantages using to fight infections, such bacterial resistance. This review highlights therapeutic approaches dressings functionalized with potential role revolutionizing Moreover, physiology skin wounds discussed place use care perspective.

Language: Английский

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PLGA-Based Composites for Various Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2034 - 2034

Published: Feb. 12, 2022

Polymeric materials have been extensively explored in the field of nanomedicine; within them, poly lactic-co-glycolic acid (PLGA) holds a prominent position micro- and nanotechnology due to its biocompatibility controllable biodegradability. In this review we focus on combination PLGA with different inorganic nanomaterials form nanocomposites overcome polymer’s limitations extend applications. We discuss their physicochemical properties variety well-established synthesis methods for preparation PLGA-based materials. Recent progress design biomedical applications are thoroughly discussed provide framework future research.

Language: Английский

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The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2020, Volume and Issue: 8

Published: Feb. 11, 2020

Polymeric biomaterials have found widespread applications in nanomedicine, and PLGA particular has been successfully implemented numerous drug delivery formulations due to its synthetic malleability biocompatibility. However, the need for preconception these is increasing, this can be achieved by selection elimination of design variables order systems tailored their specific applications. The starting materials preparation methods shown influence various parameters PLGA-based nanocarriers implementation systems, while computational simulations as a component formulation studies provide valuable information on characteristics. This review provides critical summary synthesis bio-medicine outlines experimental considerations systems.

Language: Английский

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Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing

ACS Biomaterials Science & Engineering, Journal Year: 2020, Volume and Issue: 6(10), P. 5399 - 5430

Published: Aug. 25, 2020

The morbidity, mortality, and burden of burn victims patients with severe diabetic wounds are still high, which leads to an extensively growing demand for novel treatments high clinical efficacy. Biomaterial-based wound treatment approaches have progressed over time from simple cotton wool dressings advanced skin substitutes containing cells growth factors; however, no care approach is yet completely satisfying. Bioactive glasses materials potential in many areas that exhibit unique features biomedical applications. Today, bioactive not only amorphous solid structures can be used as a substitute hard tissue but also promising soft regeneration healing Biologically active elements such Ag, B, Ca, Ce, Co, Cu, Ga, Mg, Se, Sr, Zn incorporated glass networks; hence, the superiority these multifunctional current results their ability release multiple therapeutic ions environment, target different stages process. dissolution products potency inducing angiogenesis exerting several biological impacts on cell functions, involved some other valuable applications, namely hemostatic antibacterial properties. In this review, we focus structure, dynamic process injured skin, existing approaches. basic concepts reviewed better understand relationship between structure its We illustrate role repair regeneration. Finally, research studies applications summarized future trends field elaborated.

Language: Английский

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Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 112, P. 110925 - 110925

Published: April 11, 2020

Language: Английский

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