Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging DOI Creative Commons
Ramar Thangam, Ramasamy Paulmurugan, Heemin Kang

et al.

Nanomaterials, Journal Year: 2021, Volume and Issue: 12(1), P. 18 - 18

Published: Dec. 22, 2021

Functionalized nanomaterials of various categories are essential for developing cancer nano-theranostics brain diseases; however, some limitations exist in their effectiveness and clinical translation, such as toxicity, limited tumor penetration, inability to cross blood–brain blood-tumor barriers. Metal with functional fluorescent tags possess unique properties improving properties, including surface plasmon resonance (SPR), superparamagnetism, photo/bioluminescence, which facilitates imaging applications addition deliveries. Moreover, these multifunctional could be synthesized through chemical modifications on physical surfaces via attaching targeting peptides, fluorophores, quantum dots (QD), improve the application by facilitating theranostic modalities. In inherent CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PAI (Photo-acoustic imaging), X-ray contrast imaging, nanoparticles probes serve brain-targeted candidates several The primary criteria translational must zero toxicity. beneficial aspects systems proportioned towards personalized disease management comprising diagnostic therapeutic abilities a single biodegradable nanomaterial. This review highlights emerging engineered reach deliver therapeutics how this adopting modalities applications.

Language: Английский

Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components DOI Creative Commons
Robin Augustine, Anwarul Hasan, Rosita Primavera

et al.

Materials Today Communications, Journal Year: 2020, Volume and Issue: 25, P. 101692 - 101692

Published: Sept. 20, 2020

The utilization of nanomaterials in the biological and medical field is quickly progressing, particularly areas where traditional diagnostics treatment approaches have limited success. success products such as biomedical implants, wound dressings drug delivery systems rely upon their effective interaction between extracellular matrix, cells, intracellular components. Upon contact with mammalian nanoparticles (NPs) begin to interact cell membrane, cytoplasmic proteins, nucleus, other cellular organelles, which result nanoparticle internalization subsequent responses. Such responses elicited by cells a cell-nanomaterials interactions, both at molecular level, are mainly determined morphological, chemical, surface characteristics themselves. This review provides an overview how different attributes, chemical nature, size, shape, charge, topography, stiffness, functional features nanomaterials, influence interactions.

Language: Английский

Citations

371
High-potency ligands for DREADD imaging and activation in rodents and monkeys DOI Creative Commons
Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Oct. 11, 2019

Abstract Designer Receptors Exclusively Activated by Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential human applications as well. The prototypical DREADD agonist clozapine N- oxide (CNO) lacks brain entry and converts to clozapine, making it difficult apply basic translational applications. Here we report the development two novel agonists, JHU37152 JHU37160, first dedicated 18 F positron emission tomography (PET) radiotracer, [ F]JHU37107. We show that JHU37160 exhibit high vivo potency. F]JHU37107 combined PET allows detection locally-targeted neurons, at their long-range projections, enabling noninvasive longitudinal projection mapping.

Language: Английский

Citations

172
Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review DOI Open Access

Tien-Wei Yu,

Hsien‐Yuan Lane, Chieh‐Hsin Lin

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(15), P. 8208 - 8208

Published: July 30, 2021

Alzheimer's disease (AD) is a progressive neurodegenerative and accounts for most cases of dementia. The prevalence AD has increased in the current rapidly aging society contributes to heavy burden on families society. Despite profound impact AD, treatments are unable achieve satisfactory therapeutic effects or stop progression disease. Finding novel become urgent. In this paper, we reviewed approaches five categories: anti-amyloid therapy, anti-tau anti-neuroinflammatory neuroprotective agents including N-methyl-D-aspartate (NMDA) receptor modulators, brain stimulation. trend development shifting from single pathological target more complex mechanism, such as neuroinflammatory processes. While drug repositioning may accelerate pharmacological development, non-pharmacological interventions, especially repetitive transcranial magnetic stimulation (rTMS) direct (tDCS), also have potential clinical application. future, it possible physicians choose appropriate interventions individually basis precision medicine.

Language: Английский

Citations

128
Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy DOI
Ren Cai,

Huandong Xiang,

Dan Yang

et al.

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(39), P. 16113 - 16127

Published: Sept. 28, 2021

Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nanoparticles (NPs) onto the surfaces CuS nanosheets (AuPt@CuS NSs) as highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher conversion efficiency via local electromagnetic enhancement well greater radiation dose deposition form glutathione depletion reactive oxygen species generation. As result, depth tissue penetration improved, hypoxia tumor microenvironment alleviated. With efficacy radiotherapy, be eliminated without later recurrence. It believed that these will play vital role future oncotherapy with effects under guided potential dual-modality system.

Language: Английский

Citations

127
Cellular Process of Polystyrene Nanoparticles Entry into Wheat Roots DOI
Jiahui Zhu, Jia Wang, Ruonan Chen

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(10), P. 6436 - 6444

Published: April 27, 2022

Nanoscale plastic particles are widely found in the terrestrial environment and being increasingly studied recent years. However, knowledge of their translocation accumulation mechanism controlled by nanoplastic characterizations plant tissues is limited, especially cells. Here, 20 mg L–1 polystyrene nanoparticles (PS NPs) with different sizes amino/carboxy groups were employed to investigate internalization process wheat roots From results, we that uptake small-size PS NPs root was increased compared large-size ones, but no observed vascular cylinder. Similar results cellular process. Besides, cell wall could block entry while membrane not. The −NH2 group on surface benefit tissular/cellular −COOH group. both particle size functional group, should be primary factor. Our findings offer important information for understanding behaviors tissues, at level, assessing potential risk food safety, quality, agricultural sustainability.

Language: Английский

Citations

72
Lipid-based nanoparticles to address the limitations of GBM therapy by overcoming the blood-brain barrier, targeting glioblastoma stem cells, and counteracting the immunosuppressive tumor microenvironment DOI Creative Commons
Changhong Zhao,

Xinshu Zhu,

Jianmei Tan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116113 - 116113

Published: Jan. 5, 2024

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, characterized by high heterogeneity, strong invasiveness, poor prognosis, and a low survival rate. A broad range of nanoparticles have been recently developed as drug delivery systems for GBM therapy owing to their inherent size effect ability cross blood-brain barrier (BBB). Lipid-based (LBNPs), such liposomes, solid lipid NPs (SLNs), nano-structured carriers (NLCs), emerged promising system treatment because unique size, surface modification possibilities, proven bio-safety. In this review, main challenges current clinical strategies on how novel LBNPs overcome them were explored. The application progress LBNP-based in chemotherapy, immunotherapy, gene recent years systematically reviewed, prospect was discussed.

Language: Английский

Citations

31
Dancing with reactive oxygen species generation and elimination in nanotheranostics for disease treatment DOI
Zijian Zhou, Kaiyuan Ni, Hongzhang Deng

et al.

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 158, P. 73 - 90

Published: Jan. 1, 2020

Language: Английский

Citations

109
ApoE-Targeting Increases the Transfer of Solid Lipid Nanoparticles with Donepezil Cargo across a Culture Model of the Blood–Brain Barrier DOI Creative Commons
Gizem Rüya Topal, Mária Mészáros, Gergő Porkoláb

et al.

Pharmaceutics, Journal Year: 2020, Volume and Issue: 13(1), P. 38 - 38

Published: Dec. 29, 2020

Pharmacological treatment of central nervous system (CNS) disorders is difficult, because the blood–brain barrier (BBB) restricts penetration many drugs into brain. To solve this unmet therapeutic need, nanosized drug carriers are focus research efforts to develop delivery systems for CNS. For successful nanoparticles (NPs) brain, targeting ligands on their surface necessary. Our aim was design a nanoscale more efficient transfer donepezil, an anticholinergic in therapy Alzheimer’s disease across BBB. Rhodamine B-labeled solid lipid with donepezil cargo were prepared and targeted apolipoprotein E (ApoE), ligand BBB receptors. Nanoparticles characterized by measurement size, polydispersity index, zeta potential, thermal analysis, Fourier-transform infrared spectroscopy, vitro release, stability. Cytotoxicity investigated metabolic assay impedance-based cell analysis. ApoE-targeting increased uptake cultured brain endothelial cells neurons. Furthermore, permeability ApoE-targeted co-culture model also elevated. data indicate that ApoE, which binds receptors, can potentially be exploited CNS nanoparticles.

Language: Английский

Citations

96
Advances in developing therapeutic strategies for Alzheimer's disease DOI Open Access
Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Thi Kim Oanh Nguyen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 139, P. 111623 - 111623

Published: April 26, 2021

Alzheimer's disease (AD) is a progressive deterioration of brain function, initially characterized by cognitive deficits, with loss recent memory and language ability, impairment orientation, problem solving, abstract thinking. While existing drug treatments help reduce the symptoms AD improve people's quality life, they neither slow its progression nor cure it. Currently, targeted delivery to central nervous system (CNS), for therapy AD, confined challenges posed blood-brain interfaces surrounding CNS, limiting bioavailability therapeutics. Among new strategies overcome these limitations successfully deliver drugs nanoparticles (NPs) are able limitations, offering therapeutic designations in term driving cross BBB enter more effectively. The current article aimed summary highlight advances research on development nanotechnology-based therapeutics their implications AD.

Language: Английский

Citations

80
A comprehensive review on the applications of nano-biosensor-based approaches for non-communicable and communicable disease detection DOI
Rout George Kerry, Kingsley Eghonghon Ukhurebor,

Swati Kumari

et al.

Biomaterials Science, Journal Year: 2021, Volume and Issue: 9(10), P. 3576 - 3602

Published: Jan. 1, 2021

The outstretched applications of biosensors in diverse domains has become the reason for their attraction scientific communities. Because they are analytical devices, can detect both quantitative and qualitative biological components through generation detectable signals. In recent past, witnessed significant changes developments design as well features. Nanotechnology revolutionized sensing phenomena by increasing biodiagnostic capacity terms specificity, size, cost, resulting exceptional sensitivity flexibility. steep increase non-communicable diseases across world emerged a matter concern. parallel, abrupt outbreak communicable poses serious threat to mankind. For decreasing morbidity mortality associated with various diseases, early detection subsequent treatment indispensable. Detection different markers generates quantifiable signals that be electrochemical, mass-based, optical, thermal, or piezoelectric. Speculating on incumbent applicability versatility nano-biosensors large disciplines, this review highlights types along mechanisms. Moreover, it deals current advancements made future prospects diagnostics.

Language: Английский

Citations

69