Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 29, 2024
Abstract
The
deployment
of
imaging
examinations
has
evolved
into
a
robust
approach
for
the
diagnosis
lymph
node
metastasis
(LNM).
advancement
technology,
coupled
with
introduction
innovative
drugs,
led
to
incorporation
an
increasingly
diverse
array
techniques
clinical
practice.
Nonetheless,
conventional
methods
administering
agents
persist
in
presenting
certain
drawbacks
and
side
effects.
employment
controlled
drug
delivery
systems
(DDSs)
as
conduit
transporting
offers
promising
solution
ameliorate
these
limitations
intrinsic
metastatic
(LN)
imaging,
thereby
augmenting
diagnostic
precision.
Within
scope
this
review,
we
elucidate
historical
context
LN
encapsulate
frequently
employed
DDSs
conjunction
variety
techniques,
specifically
imaging.
Moreover,
engage
discourse
on
conceptualization
practical
application
fusing
treatment
by
employing
DDSs.
Finally,
venture
prospective
applications
realm
LNM
share
our
perspective
potential
trajectory
DDS
development.
Graphical
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(1), P. 131 - 131
Published: Jan. 19, 2024
Lipid
nanoparticles
(LNPs)
have
gained
prominence
as
primary
carriers
for
delivering
a
diverse
array
of
therapeutic
agents.
Biological
products
achieved
solid
presence
in
clinical
settings,
and
the
anticipation
creating
novel
variants
is
increasing.
These
predominantly
encompass
proteins,
nucleic
acids
messenger
RNA.
The
advancement
efficient
LNP-based
delivery
systems
biologics
that
can
overcome
their
limitations
remains
highly
favorable
formulation
strategy.
Moreover,
given
small
size,
biocompatibility,
biodegradation,
LNPs
proficiently
transport
moiety
into
cells
without
significant
toxicity
adverse
reactions.
This
especially
crucial
existing
upcoming
biopharmaceuticals
since
large
molecules
group
present
several
challenges
be
by
LNPs.
review
describes
LNP
technology
summarizes
developments
chemistry,
manufacturing,
characterization
lipids
used
development
biologics.
Finally,
we
perspective
on
potential
opportunities
current
pertaining
to
technology.
Lab on a Chip,
Journal Year:
2024,
Volume and Issue:
24(5), P. 1154 - 1174
Published: Jan. 1, 2024
The
current
landscape
of
microfluidic
technologies
for
lipid
nanoparticle
production,
size
control,
scaling,
and
nanomedicine
post-processing
is
described
in
a
review
this
evolving
field.
Small,
Journal Year:
2024,
Volume and Issue:
20(19)
Published: Feb. 7, 2024
Abstract
Immunotherapy
has
emerged
as
a
potent
strategy
in
cancer
treatment,
with
many
approved
drugs
and
modalities
the
development
stages.
Despite
its
promise,
immunotherapy
is
not
without
limitations,
including
side
effects
suboptimal
efficacy.
Using
nanoparticles
(NPs)
delivery
vehicles
to
target
lymph
nodes
(LNs)
can
improve
efficacy
of
reduce
patients.
In
this
context,
paper
reviews
LN‐targeted
immunotherapeutic
NP
strategies,
mechanisms
transport
during
LN
targeting,
their
related
biosafety
risks.
targeting
LNs
involves
either
passive
influenced
by
physical
properties,
or
active
facilitated
affinity
ligands
on
surfaces,
while
alternative
methods,
such
intranodal
injection
high
endothelial
venule
(HEV)
have
uncertain
clinical
applicability
require
further
research
validation.
NPs
for
increase
biocompatibility,
but
risks
toxicity,
organ
accumulation,
oxidative
stress
remain,
although
strategies
biodegradable
biomacromolecules,
polyethylene
glycol
(PEG)
coating,
impurity
addition
mitigate
these
Additionally,
work
concludes
future‐oriented
discussion,
offering
critical
insights
into
field.
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(24), P. 4773 - 4792
Published: Jan. 1, 2021
Throughout
the
past
decade,
there
has
been
a
rapid
growth
in
development
of
protein/peptide-based
therapeutics.
These
therapeutics
have
found
widespread
applications
treatment
cancer,
infectious
diseases,
and
other
metabolic
disorders
owing
to
their
several
desirable
attributes,
such
as
reduced
toxicity,
diverse
biological
activities,
high
specificity,
potency.
Most
drugs
are
still
administered
parenterally,
is
an
unprecedented
demand
pharmaceutical
industry
develop
oral
delivery
routes
increase
patient
acceptability
convenience.
Recent
advancements
nanomedicine
discoveries
led
nano
micro-particle-based
platforms
for
among
these,
liposomes
emerged
prominent
candidate.
Liposomes
spherical
vesicles
composed
one
or
more
phospholipid
bilayers
enclosing
core
aqueous
phase.
Their
unique
amphiphilic
nature
enables
encapsulation
range
bioactives/drugs
including
both
hydrophobic
hydrophilic
compounds
delivery.
Against
this
backdrop,
review
provides
overview
current
approaches
challenges
associated
with
methods
administration
by
using
potential
vehicle.
First,
conventional
innovative
liposome
formation
discussed
along
applications.
Next,
protein
peptide-derived
thoroughly
addressed.
Lastly,
we
critically
reviewed
utilization
vehicles
proteins
emphasizing
status
future
directions
area.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(28), P. 15459 - 15465
Published: April 27, 2021
A
tumor-targeting
enhanced
chemotherapy,
enabled
by
aptamer-drug
conjugate
nanomicelles,
is
reported
that
boosts
antitumor
immune
responses.
Multivalent
aptamer
drug
(ApMDC),
an
amphiphilic
telodendrimer
consisting
of
a
hydrophilic
and
hydrophobic
monodendron
anchored
with
four
anticancer
drugs
acid-labile
linkers,
was
designed
synthesized.
By
co-self-assembly
ApMDC
analogue,
in
which
replaced
polyethylene
glycol,
the
surface
density
these
nanomicelles
can
be
screened
to
reach
optimal
complementation
between
blood
circulation
ability.
Optimized
enhance
immunogenic
cell
death
tumor
cells,
strikingly
augments
tumor-specific
responses
checkpoint
blockade
immunocompetent
tumor-bearing
mice.
represent
robust
platform
for
structure-function
optimization
conjugates
nanomedicines.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(4), P. 5184 - 5232
Published: March 29, 2022
In
addition
to
the
contribution
of
cancer
cells,
solid
tumor
microenvironment
(TME)
has
a
critical
role
in
determining
expansion,
antitumor
immunity,
and
response
immunotherapy.
Understanding
details
complex
interplay
between
cells
components
TME
provides
an
unprecedented
opportunity
explore
combination
therapy
for
intervening
immune
landscape
improve
immunotherapy
outcome.
One
approach
is
introduction
multifunctional
nanocarriers,
capable
delivering
drug
combinations
that
provide
immunogenic
stimuli
improvement
antigen
presentation,
contemporaneous
with
delivery
coformulated
or
synthetic
molecules
danger
signals
interfere
immune-escape,
immune-suppressive,
T-cell
exclusion
pathways.
This
forward-looking
review
will
discuss
use
lipid-bilayer-encapsulated
liposomes
mesoporous
silica
nanoparticles
heterogeneous
landscapes
pancreatic
ductal
adenocarcinoma
triple-negative
breast
cancer.
We
describe
how
remote
loading
lipid
bilayer
encapsulation
used
synthesis
synergistic
induce
cell
death,
PD-1/PD-L1
axis,
inhibit
indoleamine-pyrrole
2,3-dioxygenase
(IDO-1)
metabolic
pathway,
restore
spatial
access
activated
T-cells
site,
reduce
impact
immunosuppressive
stromal
components.
show
integration
current
knowledge
future
discovery
can
be
rational
nanoenabled
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1940 - 1940
Published: Sept. 14, 2022
Nanoparticulate
technologies
have
revolutionized
drug
delivery
allowing
for
passive
and
active
targeting,
altered
biodistribution,
controlled
release
(temporospatial
or
triggered),
enhanced
stability,
improved
solubilization
capacity,
a
reduction
in
dose
adverse
effects.
However,
their
manufacture
remains
immature,
challenges
exist
on
an
industrial
scale
due
to
high
batch-to-batch
variability
hindering
clinical
translation.
Lipid-based
nanomedicines
remain
the
most
widely
approved
nanomedicines,
current
manufacturing
methods
discontinuous
face
several
problems
such
as
affecting
critical
quality
attributes
(CQAs)
of
product,
laborious
multistep
processes,
need
expert
workforce,
not
being
easily
amenable
scale-up
involving
typically
complex
process
control.
Several
techniques
emerged
recent
years
nanomedicine
manufacture,
but
paradigm
shift
occurred
when
microfluidic
strategies
able
mix
fluids
channels
with
dimensions
tens
micrometers
small
volumes
liquid
reagents
highly
manner
form
nanoparticles
tunable
reproducible
structure
were
employed.
In
this
review,
we
summarize
advancements
lipid-based
using
microfluidics
particular
emphasis
parameters
that
govern
control
CQAs
final
nanomedicines.
The
impact
environments
formation
dynamics
nanomaterials,
application
microdevices
platforms
nanomaterial
screening
are
also
discussed.
