Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 347, P. 104 - 114
Published: May 6, 2022
Language: Английский
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(21)
Published: March 31, 2022
Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising agents to overcome insufficient immunogenicity cells and poor immune response encountered in PTI still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic properties as well ability perturb redox homeostasis potentiate responsiveness. OMAs, assembled from charge-transfer complexes characterized by broad substrate scope, high accessibility, flexibly tuned optical properties, demonstrate strong phototherapeutic adjuvant abilities via depletion glutathione cysteine, subsequently elicit systemic immunity evoking immunogenic cell death, promoting dendritic maturation, increasing T infiltration. Furthermore, programmed death protein 1 antibody can be employed synergize OMAs suppress evasion ultimately improve treatment outcomes. This study unlocks new paradigms provide versatile OMA-based scaffold future practical applications.
Language: Английский
Citations
81
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Nov. 1, 2022
Cancer vaccine, which can promote tumor-specific immunostimulation, is one of the most important immunotherapeutic strategies and holds tremendous potential for cancer treatment/prevention. Here, we prepare a series nanoparticles composed doxorubicin- tyrosine kinase inhibitor-loaded hyaluronic acid-coated dendritic polymers (termed HDDT nanoparticles) find that convert various cells to micrometer-sized vesicles (1.6−3.2 μm; termed HMVs) with ~100% cell-to-HMV conversion efficiency. We confirm in two tumor-bearing mouse models restrain tumor growth, induce robust immunogenic cell death, primary into an antigen depot by producing HMVs situ serve as personalized vaccines immunotherapy. Furthermore, HDDT-healed mice show strong immune memory effect treatment realize long-term protection against rechallenge. Collectively, present work provides general strategy preparation tumor-associated antigen-containing development vaccines. Autologous elicit anti-tumor responses. authors report design polymer-based loaded doxorubicin inhibitor apatinib death production immuno-stimulatory vesicles, promoting responses preclinical models.
Language: Английский
Citations
70
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332
Published: July 17, 2023
Language: Английский
Citations
47
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(42)
Published: June 24, 2023
Abstract Induction of immunogenic cell death (ICD) represents a robust therapeutic strategy for cancer treatment. However, only few ICD inducers are currently available and many them take effect based on traditional endoplasmic reticulum (ER) stress rather than mitochondrial stress. Besides, mitochondrion is closely related to ER drug delivery via targeting usually shows higher efficiency cytotoxicity that targeting, which inspires explore the cells through Herein, mito‐missile can realize not mitochondria‐targeted photodynamic therapy (PDT)/mild‐temperature photothermal (MTPTT) but also ICD‐induced immunotherapy constructed. The (termed DIH) prepared by coating dc‐IR825 (a mitochondrion‐targeting cyanine dye)‐loaded polyamidoamine dendrimer with hyaluronic acid. precisely target mitochondria produce reactive oxygen species (ROS) mild heat upon near‐infrared (NIR) light irradiation, inducing damage stress‐caused enhanced ICD. By combining PDT, MTPTT, immunotherapy, DIH efficiently inhibit tumor growth even eradicate tumors. This study develops dendrimer‐based nanoplatform realizing mitochondrion‐acting PDT/MTPTT as well stress‐induced potentiated ICD, may provide guideline designing effective in future.
Language: Английский
Citations
46
Nano Letters, Journal Year: 2023, Volume and Issue: 23(14), P. 6544 - 6552
Published: July 4, 2023
As a ROS scavenger, resveratrol exerts neuroprotective effect by polarizing the M1 microglia to anti-inflammatory M2 phenotype for ischemic stroke treatment. However, obstruction of blood–brain barrier (BBB) seriously impairs efficacy resveratrol. Herein, we develop stepwise targeting nanoplatform enhanced therapy, which is fabricated pH-responsive poly(ethylene glycol)-acetal-polycaprolactone-poly(ethylene glycol) (PEG-Acetal-PCL-PEG) and modified with cRGD triphenylphosphine (TPP) on long PEG chain short chain, respectively. The as-designed micelle system features effective BBB penetration through cRGD-mediated transcytosis. Once entering brain tissues endocytosed microglia, shell can be detached from micelles in acidic lysosomes, subsequently exposing TPP target mitochondria. Thus, effectively alleviate oxidative stress inflammation delivery mitochondria, reversing scavenging ROS. This work offers promising strategy treat ischemia-reperfusion injury.
Language: Английский
Citations
46
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 7, 2025
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity known used, they often fail to achieve satisfactory long-term patient outcomes survival. Recently, immunotherapy has shown success patients by harnessing important interactions between immune system cancer. However, many these therapies lead frequent side effects when administered systemically, prompting treatment modifications or discontinuation or, severe cases, fatalities. New approaches like intratumoral immunotherapy, characterized reduced effects, cost, systemic toxicity, offer promising prospects for future applications clinical oncology. In context locally metastatic cancer, combining diverse immunotherapeutic other targeting multiple cancer hallmarks appears crucial. Such combination hold promise improving survival promoting a sustained response. This review aims provide overview approaches, specifically focusing on administration drugs cancers. It also explores integration modalities maximize Additionally, summarizes recent advances discusses novel outlining directions field.
Language: Английский
Citations
2
Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515
Published: Jan. 1, 2025
Language: Английский
Citations
2
Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(34), P. 13519 - 13524
Published: Aug. 23, 2021
The performance of photodynamic therapy (PDT) depends on the solubility, pharmacokinetic behaviors, and photophysical properties photosensitizers (PSs). However, highly conjugated PSs with strong reactive oxygen species (ROS) generation efficiency tend to have poor solubility aggregate in aqueous environments, leading suboptimal PDT performance. Here, we report a new strategy load but poorly soluble zinc-phthalocyanine (ZnP) pores Hf12-QC (QC = 2″,3'-dinitro-[1,1':4',1";4″,1'"-quaterphenyl]-4,4'"-dicarboxylate) nanoscale metal-organic framework afford ZnP@Hf-QC spatially confined ZnP PSs. avoids aggregation-induced quenching excited states significantly enhance ROS upon light irradiation. With higher cellular uptake, enhanced generation, better biocompatibility, mediated exhibited an IC50 0.14 μM achieved exceptional antitumor efficacy >99% tumor growth inhibition 80% cure rates two murine colon cancer models.
Language: Английский
Citations
101
Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 335, P. 1 - 20
Published: May 12, 2021
Language: Английский
Citations
96