ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
13(26), P. 31180 - 31192
Published: June 27, 2021
Poor
mechanical
properties
and
freezing
at
low
temperatures
of
traditional
photochromic
hydrogels
limit
their
applications.
Here,
a
novel
type
nanocomposite
organohydrogels
(NC
OGHs)
by
adding
tungsten
oxide
nanoparticles
was
prepared
simple
one-pot
method.
The
NC
OGHs
demonstrated
excellent
integrated
properties,
including
high
transparency,
low-temperature
resistance,
anti-dehydration,
rewrite
capability,
UV
blocking
ability.
In
addition,
the
degree
coloration
could
be
precisely
controlled
irradiation,
bleaching
process
temperature
atmosphere.
Besides
flexible
optical
information
storage
devices
filters,
these
were
also
used
for
smart
windows
in
both
room
cold
environments.
work
provides
new
insight
into
organohydrogels.
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(15)
Published: May 24, 2022
Abstract
Antibacterial
hydrogels,
particularly
antibiotic‐loaded
are
promising
wound
dressing
materials
for
treatment
of
bacteria‐infected
wound.
However,
it
is
challenging
to
achieve
sustained
release
antibiotics
from
hydrogels
through
physical
encapsulation
the
antibiotics.
Herein,
an
interpenetrating
polymer
network
P(AA‐
co
‐HEMA)
Gen
hydrogel
reported
with
double
crosslinking
formed
by
free
radical
polymerization
2‐hydroxyethyl
methacrylate
(HEMA)
and
acrylic
acid
(AA),
while
using
antibiotic
gentamicin
(Gen)
as
dynamic
crosslinker.
Gentamicin
incorporated
into
networks
via
electrostatic
interaction
between
carboxyl
groups
poly(acrylic
acid)
amino
gentamicin,
which
leads
pH‐responsive
drug
a
significant
increase
in
mechanical
strength
(i.e.,
elastic
modulus,
viscous
compressive
modulus).
More
importantly,
optimal
compositions
demonstrate
long‐lasting
antibacterial
activity
against
both
Gram‐positive
bacteria
(
Staphylococcus
aureus
)
Gram‐negative
Escherichia
coli
over
28
d.
The
vivo
studies
that
conducted
S.
‐infected
full‐thickness
skin
model
loaded
eliminate
wounds
more
effectively
significantly
accelerate
healing
compared
3M
control
without
any
treatment.
Taken
together,
this
potentially
material
Advanced Materials Technologies,
Journal Year:
2022,
Volume and Issue:
7(7)
Published: Feb. 11, 2022
Abstract
Forming
natural
polymers‐based
hydrogels
with
enhanced
mechanical
strength,
outstanding
antifreezing
property
and
superior
conductivity
is
still
a
challenge.
Here,
gelatin/oxidized
dextran
hydrogel
fabricated
it
shows
performance,
antifreeze
tolerance,
due
to
the
synergistic
interaction
of
ammonium
sulfate
betaine.
The
resulting
dextran/(NH
4
)
2
SO
/betaine
exhibits
high
stretchability
(570%),
tough
tensile
(2.49
MPa)
compressive
(46.41
fracture
favorable
(6.05
MJ
m
−3
(3.08
toughness,
(−30
°C)
(2.86
S
−1
).
Based
on
above
characteristics,
applied
for
strain
sensor
monitor
joints
motion
human
body
such
as
finger,
wrist,
elbow,
knee,
neck,
throat.
can
maintain
good
performance
stable
sensing
signal
from
25
−30
°C.
Therefore,
designed
based
polymers
huge
potential
tissue
engineering
biosensing
under
mild
or
extreme
environment.
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(16)
Published: June 9, 2022
Micrometer-sized
hydrogels
are
cross-linked
three-dimensional
network
matrices
with
high-water
contents
and
dimensions
ranging
from
several
to
hundreds
of
micrometers.
Due
their
excellent
biocompatibility
capability
mimic
physiological
microenvironments
in
vivo,
micrometer-sized
have
attracted
much
attention
the
biomedical
engineering
field.
Their
biological
properties
applications
primarily
influenced
by
chemical
compositions
geometries.
However,
inhomogeneous
morphologies
uncontrollable
geometries
limit
traditional
obtained
bulk
mixing.
In
contrast,
microfluidic
technology
holds
great
potential
for
fabrication
since
geometries,
sizes,
structures,
compositions,
physicochemical
can
be
precisely
manipulated
on
demand
based
control
over
fluids.
Therefore,
fabricated
been
applied
field,
including
drug
encapsulation,
cell
tissue
engineering.
This
review
introduces
various
synthesized
different
devices,
highlighting
advantages
those
approaches.
Overall,
emerging
technologies
enrich
accelerate
translation
industrial
production
clinical
applications.
Journal of Materials Chemistry A,
Journal Year:
2023,
Volume and Issue:
11(6), P. 2996 - 3007
Published: Jan. 1, 2023
Stretchable
and
tough
double-network
hydrogels
mediated
by
CaCO
3
microparticles
can
be
used
to
monitor
human
motions
mild
pain
signals
at
the
wound
site.
Regenerative Therapy,
Journal Year:
2024,
Volume and Issue:
26, P. 260 - 274
Published: June 1, 2024
Chronic
wounds
represent
a
significant
global
burden,
afflicting
millions
with
debilitating
complications.
Despite
standard
care,
impaired
healing
persists
due
to
factors
like
persistent
inflammation
and
tissue
regeneration.
Mesenchymal
stem
cell
(MSC)-derived
extracellular
vesicles
(EVs)
offer
an
innovative
regenerative
medicine
approach,
delivering
cell-derived
therapeutic
cargo
in
engineered
nanoscale
delivery
systems.
This
review
examines
pioneering
bioengineering
strategies
engineer
MSC-EVs
into
precision
nanotherapeutics
for
chronic
wounds.
Emerging
technologies
CRISPR
gene
editing,
microfluidic
manufacturing,
biomimetic
systems
are
highlighted
their
potential
enhance
MSC-EV
targeting,
optimize
enrichment,
ensure
consistent
clinical-grade
production.
However,
key
hurdles
remain,
including
batch
variability,
rigorous
safety
assessment
tumorigenicity,
immunogenicity,
biodistribution
profiling.
Crucially,
collaborative
frameworks
harmonizing
regulatory
science
patient
advocacy
hold
the
expediting
clinical
translation.
By
overcoming
these
challenges,
could
catalyze
new
era
of
off-the-shelf
therapies,
restoring
hope
afflicted
by
non-healing
