Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122645 - 122645
Published: May 28, 2024
Language: Английский
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 9, 2024
Abstract Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial infection, chronic inflammation, cancer progression organ degeneration, but the mechanism regulation of crosstalk network remain unclear. Main body abstract Cellular stress disrupts mitochondrial homeostasis, facilitates opening permeability transition pore leakage DNA to cell membrane, triggers inflammatory responses by activating cGAS-STING signaling, subsequently induces activation onset pyroptosis. Meanwhile, inflammasome-associated protein caspase-1, Gasdermin D, CARD domain ASC potassium channel are involved in regulating pathway. Importantly, this has a cascade amplification effect that exacerbates immuno-inflammatory response, worsening pathological process autoimmune diseases. Given importance innate immunity, it is emerging new avenue explore mechanisms multiple disease pathogenesis. Therefore, efforts define strategies selectively modulate different settings have been or ongoing. In review, we will describe how mechanistic understanding driving possible therapeutics targeting network, focusing on interacting regulatory proteins, pathways, hub between inflammasomes, Short conclusion This review aims provide insight into roles pyroptosis, highlight some promising directions future research intervention.
Language: Английский
Citations
28
ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10439 - 10453
Published: April 3, 2024
The cGAS-STING pathway plays a crucial role in innate immune activation against cancer and infections, STING agonists based on cyclic dinucleotides (CDN) have garnered attention for their potential use immunotherapy vaccines. However, the limited drug-like properties of CDN necessitate an efficient delivery system to system. To address these challenges, we developed immunostimulatory agonists. Here, examined aqueous coordination interactions between metal ions report that mixed with Zn2+ Mn2+ formed distinctive crystal structures. Further pharmaceutical engineering led development functional nanoparticle, termed Zinc–Mn–CDN Particle (ZMCP), produced by simple one-pot synthesis. Local or systemic administration ZMCP exerted robust antitumor efficacy mice. Importantly, recombinant protein antigens from SARS-CoV-2 can be simply loaded during resulting elicited strong cellular humoral responses neutralized SARS-CoV-2, highlighting as self-adjuvant vaccine platform COVID-19 other infectious pathogens. Overall, this work establishes paradigm developing translational nanomedicine drug–metal ion broadens applicability medicine proteins biologics.
Language: Английский
Citations
24
Small, Journal Year: 2024, Volume and Issue: 20(35)
Published: May 1, 2024
Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.
Language: Английский
Citations
24
BMEMat, Journal Year: 2024, Volume and Issue: 2(2)
Published: Feb. 27, 2024
Abstract Activating the stimulator of interferon genes (STING) signaling pathway is critical for enhancing antitumor immunity and remodeling immunosuppressive tumor microenvironment (TME). Herein, we report preparation STING‐activating nanoparticles via metal coordination‐driven assembly a synthetic STING agonist (i.e., SR717) chemotherapeutic drug curcumin). After intravenous administration, assembled could efficiently accumulate in tumors to improve bioavailability SR717 trigger potent activation effective immune responses. Meanwhile, released curcumin evokes immunogenic cell death regulates amino acid metabolism by inhibiting indoleamine 2,3‐dioxygenase 1, leading reversal TME. The induced significantly inhibits growth primary, recurrent, metastatic tumors. are promising co‐delivery agonists drugs improved chemo‐immunotherapy.
Language: Английский
Citations
17
Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(4), P. 1768 - 1799
Published: Feb. 7, 2024
Adjuvants are of critical value in vaccine development as they act on enhancing immunogenicity antigen and inducing long-lasting immunity. However, there only a few adjuvants that have been approved for clinical use, which highlights the need exploring developing new to meet growing demand vaccination. Recently, emerging evidence demonstrates cGAS-STING pathway orchestrates innate adaptive immunity by generating type I interferon responses. Many agonists developed tested preclinical research treatment cancer or infectious diseases with promising results. As adjuvants, demonstrated their potential activate robust defense various diseases, including COVID-19 infection. This review summarized current developments field special focus latest applications Potential challenges were also discussed hope sparking future interests further adjuvants.
Language: Английский
Citations
16
Science Advances, Journal Year: 2022, Volume and Issue: 8(51)
Published: Dec. 23, 2022
It is urgent to develop more effective mRNA vaccines against the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants owing immune escape. Here, we constructed a novel delivery system [IC8/Mn lipid nanoparticles (IC8/Mn LNPs)]with high immunogenicity, via introducing stimulator of interferon genes (STING) agonist [manganese (Mn)] based on newly synthesized ionizable (IC8). was found that Mn can not only promote maturation antigen-presenting cells activating STING pathway but also improve expression by facilitating lysosomal escape for first time. Subsequently, IC8/Mn LNPs loaded with encoding Spike protein SARS-CoV-2 Delta or Omicron variant (IC8/Mn@D IC8/Mn@O) were prepared. Both induced substantial specific immunoglobulin G responses Omicron. IC8/Mn@D displayed strong pseudovirus neutralization ability, T helper 1-biased responses, and good safety. be concluded have great potential developing Mn-coordinated robust immunogenicity
Language: Английский
Citations
56
Vaccines, Journal Year: 2022, Volume and Issue: 10(11), P. 1906 - 1906
Published: Nov. 11, 2022
With the support of modern biotechnology, vaccine technology continues to iterate. The safety and efficacy vaccines are some most important areas development in field. As a natural substance, chitosan is widely used numerous fields—such as immune stimulation, drug delivery, wound healing, antibacterial procedures—due its good biocompatibility, low toxicity, biodegradability, adhesion. Chitosan-based nanoparticles (NPs) have attracted extensive attention with respect adjuvants delivery systems due their excellent properties, which can effectively enhance responses. Here, we list classifications mechanisms action adjuvants. At same time, preparation methods chitosan, NPs, mechanism system introduced. applications NPs protein nucleic acid also This paper reviewed latest research progress chitosan-based adjuvant systems.
Language: Английский
Citations
55
Materials Horizons, Journal Year: 2022, Volume and Issue: 10(2), P. 361 - 392
Published: Nov. 29, 2022
Polymeric nanoparticle-based cancer vaccines with the components of antigens ( ex vivo and in situ ) different immune adjuvants.
Language: Английский
Citations
52
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(15), P. 5172 - 5254
Published: Jan. 1, 2023
This review provides an introduction of basic principles adjuvanted human vaccines in clinics and summarizes emerging nanotechnology adjuvants vaccine development against cancer infectious diseases.
Language: Английский
Citations
37
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100839 - 100839
Published: Oct. 21, 2023
STING (Stimulator of Interferon Genes) agonists have emerged as promising agents in the field cancer immunotherapy, owing to their excellent capacity activate innate immune response and combat tumor-induced immunosuppression. This review provides a comprehensive exploration strategies employed develop effective formulations for agonists, with particular emphasis on versatile nano-delivery systems. The recent advancements delivery systems based lipids, natural/synthetic polymers, proteins are summarized. preparation methodologies nanoprecipitation, self-assembly, hydrogel, along advantages disadvantages, also discussed. Furthermore, challenges opportunities developing next-generation agonist elaborated. aims serve reference researchers designing novel immunotherapy.
Language: Английский
Citations
37