Lymph node-targeting nanovaccines for cancer immunotherapy

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 102 - 122

Published: Sept. 20, 2022

Language: Английский

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Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 440 - 462

Published: Sept. 6, 2023

Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid solid cancers. However, tumor microenvironment (TME) is highly immunosuppressive hampers effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in design engineering nanomaterials opened new avenues to modulate TME. Progress current nanocomposite technology can overcome immunosuppression trigger robust immunotherapeutic responses by integrating synergistic functions different molecules. We will review recent advancements nanomedical applications discuss specifically designed nanocomposites modulating TME immunotherapy. In addition, we provide information landscape clinical-stage

Language: Английский

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Cancer cell membrane–encapsulated biomimetic nanoparticles for tumor immuno-photothermal therapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 463, P. 142495 - 142495

Published: March 20, 2023

Language: Английский

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A General Biomineralization Strategy to Synthesize Autologous Cancer Vaccines with cGAS-STING Activating Capacity for Postsurgical Immunotherapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 10496 - 10510

Published: May 15, 2023

Autologous cancer vaccines constructed by nonproliferative whole tumor cells or lysates together with appropriate adjuvants represent a promising strategy to suppress postsurgical recurrence. Inspired the potency of cytosolic double-stranded DNA (dsDNA) in initiating anticancer immunity activating cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway, we herein report concise synthesis cGAS-STING agonist through dsDNA-templated biomineralization growth calcium carbonate (CaCO3) microparticles. The yielded DNA@CaCO3 can activate intracellular pathway dendritic (DCs) promoting endosomal escape dsDNA, triggering their maturation and activation as potent immune stimulator. Upon intratumoral injection, reverse immunosuppressive microenvironment simultaneously provoking innate adaptive antitumor immunity, thereby effectively suppressing murine CT26 B16–F10 tumors mice. Furthermore, via CaCO3-based complete lysates, personalized autologous vaccine intrinsic capacity that could provoke tumor-specific responses not only delay challenged but also synergize anti-PD-1 immunotherapy This study highlights method prepare manner, which is for clinical translation.

Language: Английский

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Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 6, 2023

The advent of immunotherapy has marked a new era in cancer treatment, offering significant clinical benefits. Cell membrane as drug delivery materials played crucial role enhancing therapy because their inherent biocompatibility and negligible immunogenicity. Different cell membranes are prepared into nanovesicles (CMNs), but CMNs have limitations such inefficient targeting ability, low efficacy, unpredictable side effects. Genetic engineering deepened the critical immunotherapy, enabling genetically engineered-CMN (GCMN)-based therapeutics. To date, that surface modified by various functional proteins been developed through genetic engineering. Herein, brief overview strategies for features sources is discussed, followed description GCMN preparation methods. application GCMNs directed at different immune targets addressed challenges prospects translation.

Language: Английский

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Tumor Cell Nanovaccines Based on Genetically Engineered Antibody‐Anchored Membrane

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(13)

Published: Jan. 30, 2023

Abstract Despite the promise in whole‐tumor cell vaccines, a key challenge is to overcome lack of costimulatory signals. Here, agonistic‐antibody‐boosted tumor nanovaccines are reported by genetically engineered antibody‐anchored membrane (AAM) technology, capable effectively activating pathways. Specifically, AAM can be stably constructed following genetic engineering membranes with anti‐CD40 single chain variable fragment (scFv), an agonistic antibody induce The versatilely designed and obtained based on scFv‐anchored nanotechnology. Following vaccination, nanovaccine (Nano‐AAM/CD40) significantly facilitates dendritic maturation CD40‐humanized transgenic mice subsequent adaptive immune responses. Compared membrane‐based alone, enhanced antitumor efficacy both “hot” “cold” models Nano‐AAM/CD40 demonstrates importance antibodies development tumor‐cell‐based vaccines. To expand design nanovaccines, further incorporation lysates into conceptually construct cell‐like results boosted responses improved against malignant tumors inoculated mice. Overall, this technology provides versatile components checkpoints.

Language: Английский

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Targeted Reprogramming of Vitamin B₃ Metabolism as a Nanotherapeutic Strategy towards Chemoresistant Cancers

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(36)

Published: June 1, 2023

Cancer-associated fibroblasts (CAFs) promote cancer stem cell (CSC)-mediated chemoresistance and immunosuppressive tumor microenvironment. However, direct depletion of CAFs may increase invasiveness metastasis. As a generalized strategy against chemoresistant cancers, Gemini-like homotypic targeting nanoparticles (NPs) are designed for two-pronged CAF transformation elimination. The CAF-targeted NPs couple vitamin B3 metabolic reprogramming to epigenetic modulation secreted pro-stemness factors, thereby diminishing CSC suppressive immune populations enhance drug susceptibility cytotoxic T infiltration. In mouse models breast, liver, pancreatic colorectal cancers that resistant their respective first-line chemotherapeutics, single dose hydrogel co-delivering the can rehabilitate chemosensitivity, induce activation, achieve regression. Moreover, it stimulates robust memory long-term protection rechallenge. This study thus represents an innovative approach with broad applicability overcoming chemoresistance.

Language: Английский

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Tumor-derived systems as novel biomedical tools—turning the enemy into an ally

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.

Language: Английский

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Biomaterial-based platforms for modulating immune components against cancer and cancer stem cells

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 161, P. 1 - 36

Published: March 10, 2023

Language: Английский

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Homologous Tumor Targeting Molybdenum‐Doped Prussian Blue for Enhancing Immunotherapy via PTT/CDT and Remodeled Tumor Immune Microenvironment

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Immunotherapy offers a promising avenue for reducing tumor metastasis and recurrence but faces challenges from the immunosuppressive microenvironment (TIME) restricted antigen presentation. To address these challenges, this study have developed an innovative approach utilizing molybdenum (Mo)‐doped Prussian blue nanoparticles coated with cancer cell membrane (CCM), referred to as PMo@CCM. This novel nanoplatform excels in performing photothermal therapy (PTT), while Mo Fe components effectively deplete glutathione (GSH) generate reactive oxygen species (ROS), thereby significantly enhancing chemodynamic (CDT) remodeling TIME. The synergistic PTT/CDT not only induces immunogenic death (ICD) also facilitates CCM coating further supplies antigens prompts dendritic (DC) maturation. comprehensive strategy markedly enhances effectiveness of immunotherapy, evidenced by significant increase T activation. Moreover, use programmed protein 1 antibodies (anti PD‐1) blocks PD‐1 immune checkpoint pathway. RNA sequencing analysis has identified genes associated observed substantial reduction growth. In conclusion, PMo@CCM enables homologously targeted therapy, guided magnetic resonance imaging (PTI&MRI), impeding progression both primary metastatic tumors.

Language: Английский

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