Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5632 - 5632

Published: May 22, 2024

Photothermal therapy (PTT) is a promising cancer modality with significant advantages such as precise targeting, convenient drug delivery, better efficacy, and minimal adverse effects. effectively absorbs the photothermal transducers in near-infrared region (NIR), which induces effect to work. Although PTT has role tumor therapy, it also suffers from low conversion efficiency, biosafety, incomplete elimination. Therefore, use of nanomaterials themselves photosensitizers, targeted modification improve targeting or combined other therapies can therapeutic effects reduce side Notably, noble metal have attracted much attention because they strong surface plasmon resonance an effective absorbance light at specific wavelengths. be used excellent photosensitizers mediate its efficiency. This paper provides comprehensive review key played by therapy. It describes major challenges encountered during implementation

Language: Английский

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Tumor-derived systems as novel biomedical tools—turning the enemy into an ally

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.

Language: Английский

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Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2071 - 2071

Published: Feb. 8, 2024

Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle faces challenges such as short circulation time immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested practical alternative. The production process involves three main stages: lysis membrane fragmentation, isolation, coating. Cell membranes are typically fragmented using hypotonic with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. Coating can be achieved extrusion, sonication, combination of both methods. Notably, this analysis reveals the absence universally applicable method for coating, stages differ significantly their procedures. This review explores current developments approaches nanoparticles, highlighting potential an effective alternative various therapeutic applications.

Language: Английский

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Engineering customized nanovaccines for enhanced cancer immunotherapy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 330 - 357

Published: March 11, 2024

Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized through modification or functionalization has emerged a promising approach. These tailored not only enhance antigen presentation, but also effectively modulate immunosuppression within the microenvironment. Specifically, they are distinguished by diverse sizes, shapes, charges, structures, unique physicochemical properties, along with ligands. features facilitate lymph node accumulation activation/regulation immune cells. This overview bespoke underscores both prophylactic therapeutic applications, offering insights into future development role cancer immunotherapy.

Language: Английский

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Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34607 - 34619

Published: June 26, 2024

Photothermal therapy (PTT), which uses the high thermal conversion ability of photothermal agents to ablate tumor cells at temperatures, has gained significant attention because it advantages selectivity and specificity, precise targeting sites, low invasiveness trauma. However, PTT guided by NIR-I limitations in tissue penetration depth, resulting limited imaging monitoring therapeutic effects on deep-seated tissues. Moreover, nanoparticles are easily cleared immune system difficult passively target sites during process treatment. To address these issues, we prepared using NIR-II dyes IR1048 DSPE-PEG-OH further encapsulated them red blood cell membranes derived from mice. These biomimetic nanoparticles, called RDIR1048, showed reduced clearance had long circulation characteristics. They effectively accumulated strong fluorescence could still be observed site 96 h after administration. Furthermore, through mouse experiments, found that RDIR1048 exhibited good ability. When used combination with an checkpoint inhibitor, anti-PD-L1 antibodies, enhanced immunogenic death caused improved effect immunotherapy, demonstrated efficacy treatment tumor-bearing This study provides a feasible basis for future development properties.

Language: Английский

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Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286

Published: May 6, 2024

Language: Английский

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Near‐Infrared Light‐Driving Organic Photothermal Agents with an 88.9% Photothermal Conversion Efficiency for Image‐Guided Synergistic Phototherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: March 23, 2024

Photothermal agents (PTAs) with desirable near-infrared (NIR) absorption and excellent photothermal conversion efficiency (PCE) are ideal candidates for cancer treatment. However, numerous PTAs still require high-intensity long-duration laser irradiation to completely ablate the tumor during therapy (PTT) process, resulting in light damage healthy skin tissue as well limiting their biomedical applications. Integrating intense NIR high PCE into a single small-molecule PTA is an important prerequisite realizing efficient PTT, but serious challenge. Herein, series of donor-acceptor type (CC1 NC4) designed through molecular engineering strategy. Theoretical calculations experimental results show that effect from CC1 NC4 significantly enhanced expected. Notably, nanoparticles exhibit absorption, superhigh up 88.9% photoacoustic imaging imaging, effective reactive oxygen species generation photodynamic (PDT). The superior PTT/PDT synergistic phototherapeutic efficacy demonstrated by complete elimination vivo upon one-time, low-intensity, short-duration (808 nm, 330 mW cm

Language: Английский

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Cancer cell membrane biomimetic nanosystem for homologous targeted dual-mode imaging and combined therapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 652, P. 770 - 779

Published: Aug. 18, 2023

Language: Английский

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Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics

Published: Feb. 2, 2024

Nanoencapsulation has emerged as a recent improvement in the delivery of drugs, offering and improving stability bioavailability, allowing for controlled targeted substances to specific cells or tissues. However, traditional nanoparticle faces challenges such short circulation time immune recognition. To address these issues, cell membrane-coated nanoparticles have been proposed promising alternative. The production involves three key stages: lysis membrane fragmentation, isolation, coating. Typically, membranes are fragmented using hypotonic combination with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. coating can be achieved extrusion, sonication, both methods. This analysis shows absence universally applicable method coating, stages exhibit notable differences their procedures. Here we review ongoing developments approaches that position this technology alternative effective drug many other therapeutic applications.

Language: Английский

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Biomimetic Nanoparticles for Cancer Therapy: A Review of Recent Advances, Applications, and Bottlenecks

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: April 8, 2024

Biomimetic nanoparticles (BioM NPs) feature functionalization that imitates the biological surroundings, endowing them with structure and functioning. BioM NPs could be covered biologically sourced materials contain synthetic antigen-presenting cells structures. Whenever used in cancer diagnostics, outperform standard medications comparable non-BioM NPs, particularly regarding circulation time, tissue penetration, delivery, toxicity. The particles achieved extraordinary results by using cell material for which avoids difficult bottom-up approaches aim to emulate such intricate diverse components. One area of this rapidly developing research has gotten a lot interest is use treatment different cancers. However, best our knowledge, no published study primarily analysed current improvements therapy, taking into account most common tumours processes. As result, purpose present review address gap first. discussion will next go numerous recent advances therapy. This cover mechanics procedures as well their utilization therapeutics. paper then summarizes existing knowledge investigates limitations promise aims provide researchers an overview technological development It serves guide integrating future nanomedicine applications.

Language: Английский

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