Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

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Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 4, 2023

Abstract Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic acid drug (NAD) delivery. Although their clinical applications have achieved success, NAD delivery efficiency and safety still unsatisfactory, which are, to a large extent, due existence of multi‐level physiological barriers in vivo. It is important elucidate interactions between these LBNPs, will guide more rational design efficient with low adverse effects facilitate broader therapeutics. This review describes obstacles challenges biological at systemic, organ, sub‐organ, cellular, subcellular levels. The strategies overcome comprehensively reviewed, mainly including physically/chemically engineering LBNPs directly modifying by auxiliary treatments. Then potentials successful translation preclinical studies into clinic discussed. In end, forward look on manipulating protein corona (PC) addressed, may pull off trick overcoming those significantly improve efficacy LBNP‐based NADs

Language: Английский

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The interplay between PEGylated nanoparticles and blood immune system

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115044 - 115044

Published: Aug. 2, 2023

Language: Английский

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Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 22, 2024

Abstract Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one the few ways to overcome this barrier – approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis published data we prove efficacy technique for enhancing particle circulation blood and delivery tumours, describe a century its evolution potential combined mechanism behind it. Finally, discuss future directions research focusing on features essential successful clinical translation method.

Language: Английский

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Zwitterionic Poly(ethylene glycol) Nanoparticles Minimize Protein Adsorption and Immunogenicity for Improved Biological Fate

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.

Language: Английский

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Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138

Published: Jan. 28, 2025

Language: Английский

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Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114828 - 114828

Published: April 17, 2023

Language: Английский

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Multifunctional nanodrug performs sonodynamic therapy and inhibits TGF-β to boost immune response against colorectal cancer and liver metastasis

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 164, P. 538 - 552

Published: April 9, 2023

Language: Английский

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Engineered Bacterial Biomimetic Vesicles Reprogram Tumor-Associated Macrophages and Remodel Tumor Microenvironment to Promote Innate and Adaptive Antitumor Immune Responses

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 6863 - 6886

Published: Feb. 22, 2024

Tumor-associated macrophages (TAMs) are among the most abundant infiltrating leukocytes in tumor microenvironment (TME). Reprogramming TAMs from protumor M2 to antitumor M1 phenotype is a promising strategy for remodeling TME and promoting immunity; however, development of an efficient remains challenging. Here, genetically modified bacterial biomimetic vesicle (BBV) with IFN-γ exposed on surface nanoassembling membrane pore structure was constructed. The engineered BBV featured nanoscale protein lipid vesicle, existence rich pattern-associated molecular patterns (PAMPs), costimulation introduced molecules. In vitro, reprogrammed M1, possibly through NF-κB JAK-STAT signaling pathways, releasing nitric oxide (NO) inflammatory cytokines IL-1β, IL-6, TNF-α increasing expression IL-12 iNOS. tumor-bearing mice, demonstrated targeted enrichment tumors successfully into phenotype; notably, response antigen-specific cytotoxic T lymphocyte (CTL) promoted while immunosuppressive myeloid-derived suppressor cell (MDSC) suppressed. growth found be significantly inhibited both TC-1 CT26 tumor. It indicated that effects were macrophage-dependent. Further, modulation by produced synergistic against metastasis immune checkpoint inhibitor orthotopic 4T1 breast cancer model which insensitive anti-PD-1 mAb alone. conclusion, IFN-γ-modified strong capability efficiently targeting tuning cold hot reprogramming TAMs, providing potent approach immunotherapy.

Language: Английский

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Delivery Strategy to Enhance the Therapeutic Efficacy of Liver Fibrosis via Nanoparticle Drug Delivery Systems

ACS Nano, Journal Year: 2024, Volume and Issue: 18(32), P. 20861 - 20885

Published: July 31, 2024

Liver fibrosis (LF) is a pathological repair reaction caused by chronic liver injury that affects the health of millions people worldwide, progressing to life-threatening cirrhosis and cancer without timely intervention. Due complexity LF pathology, multiple etiological characteristics, deposited extracellular matrix, traditional drugs cannot reach appropriate targets in time-space matching way, thus decreasing therapeutic effect. Nanoparticle drug delivery systems (NDDS) enable multidrug co-therapy develop multifactor strategies targeting processes, showing great potential therapy. Based on pathogenesis current clinical treatment status LF, we systematically elucidate mechanism NDDS used LF. Subsequently, focus progress applications for including combined fibrotic environment, overcoming biological barriers, precise intracellular regulation, intelligent responsive microenvironment. We hope this review will inspire rational design future order provide ideas methods promoting regression cure.

Language: Английский

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