Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 301 - 318
Published: Jan. 1, 2025
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616
Published: April 16, 2024
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.
Language: Английский
Citations
236
AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(1)
Published: Jan. 18, 2023
Language: Английский
Citations
45
Chemistry, Journal Year: 2022, Volume and Issue: 4(3), P. 872 - 930
Published: Aug. 27, 2022
Magnetic nanoparticles (MNPs) have evolved tremendously during recent years, in part due to the rapid expansion of nanotechnology and their active magnetic core with a high surface-to-volume ratio, while surface functionalization opened door plethora drug, gene bioactive molecule immobilization. Taming reactivity was achieved by various techniques, producing MNPs tailored for diagnosis treatment cardiovascular or neurological disease, tumors cancer. Superparamagnetic iron oxide (SPIONs) are established at drug-delivery systems could act as efficient agents MFH (magnetic fluid hyperthermia). Depending on intrinsic morphological features, now cover broad scope which current review aims overview. Considering exponential field, will be limited roughly past three years.
Language: Английский
Citations
57
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 202, P. 115111 - 115111
Published: Oct. 10, 2023
Language: Английский
Citations
36
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 15 - 43
Published: June 20, 2023
Language: Английский
Citations
35
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1360 - 1360
Published: Sept. 26, 2023
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such heavy pill regimen, prolonged treatment duration, and strict schedule, to multidrug-resistant (MDR) extensively drug-resistant (XDR) strains. rise of MDR strains endangers future control. Despite these concerns, the hunt an efficient continues. One breakthrough has been use nanotechnology in medicines, presenting novel approach treatment. Nanocarriers, lipid nanoparticles, nanosuspensions, liposomes, polymeric micelles, facilitate targeted delivery anti-TB drugs. benefits nanocarriers include reduced drug doses, fewer side effects, improved solubility, better bioavailability, patient compliance, speeding up recovery. Additionally, can be made even more linking them ligands mannose or hyaluronic acid. This review explores innovative treatments, including studies on containing drugs related patents.
Language: Английский
Citations
26
Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(2), P. 829 - 852
Published: Jan. 2, 2023
Epidermal growth factor receptor (EGFR) plays a key role in signal transduction pathways associated with cell proliferation, growth, and survival. Its overexpression aberrant activation malignancy correlate poor prognosis short Targeting inhibition of EGFR by small-molecular tyrosine kinase inhibitors (TKIs) is emerging as an important treatment model besides chemotherapy, greatly reshaping the landscape cancer therapy. However, they are still challenged off-targeted toxicity, relatively limited types, drug resistance after long-term In this review, we summarize recent progress oral, pulmonary, injectable delivery systems for enhanced targeting TKI to tumors reduced side effects. Importantly, EGFR-TKI-based combination therapies not only broaden applicable types EGFR-TKI but also significantly improve anticancer effect. The mechanisms summarized, current strategies overcome well application reversing chemotherapy discussed. Finally, provide perspective on future research
Language: Английский
Citations
24
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1509 - 1538
Published: Feb. 1, 2024
Abstract: Lungs experience frequent interactions with the external environment and have an abundant supply of blood; therefore, they are susceptible to invasion by pathogenic microorganisms tumor cells. However, limited pharmacokinetics conventional drugs in lungs poses a clinical challenge. The emergence different nano-formulations has been facilitated advancements nanotechnology. Inhaled nanomedicines exhibit better targeting prolonged therapeutic effects. Although great potential, still present several unknown risks. Herein, we review (1) physiological anatomy their biological barriers, (2) toxicology nanomaterial formulations lungs; (3) current nanomaterials that can be applied respiratory system related design strategies, (4) applications inhaled treating disorders, vaccine design, imaging detection based on characteristics nanomaterials. Finally, (5) analyze summarize challenges prospects for disease applications. We believe nanomaterials, particularly nano-formulations, excellent application diseases. emphasize simultaneous toxic side effects must considered during these emerging medicines. This study aims offer comprehensive guidelines valuable insights conducting research domain system. Keywords: nanoparticles, system, lungs, nanotechnology
Language: Английский
Citations
13
Nanoscale, Journal Year: 2024, Volume and Issue: 16(6), P. 2820 - 2833
Published: Jan. 1, 2024
In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.
Language: Английский
Citations
10
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172240 - 172240
Published: April 4, 2024
Language: Английский
Citations
10