Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 14 - 29
Published: Jan. 16, 2025
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115005 - 115005
Published: July 5, 2023
Language: Английский
Citations
27
Small, Journal Year: 2023, Volume and Issue: 19(43)
Published: June 27, 2023
Transition metal ions are served as disinfectant thousand years ago. However, the in vivo antibacterial application of is strongly restricted due to its high affinity with proteins and lack appropriate bacterial targeting method. Herein, for first time, Zn2+ -gallic acid nanoflowers (ZGNFs) synthesized by a facile one-pot method without additional stabilizing agents. ZGNFs stable aqueous solution while can be easily decomposed acidic environments. Besides, specifically adhere onto Gram-positive bacteria, which mediated interaction quinone from amino groups teichoic bacteria. exhibit bactericidal effect toward various bacteria multiple environments, ascribed situ release on surface. Transcriptome studies reveal that disorder basic metabolic processes Methicillin-resistant Staphylococcus aureus (MRSA). Moreover, MRSA-induced keratitis model, long-term retention infected corneal site prominent MRSA elimination efficacy self-targeting ability. This research not only reports an innovative prepare metal-polyphenol nanoparticles, but also provides novel nanoplatform targeted delivery combating infections.
Language: Английский
Citations
26
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 446 - 467
Published: Sept. 8, 2023
Language: Английский
Citations
25
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 8, 2024
Abstract Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing development of dry eye disease (DED). The currently available drops DED treatment are palliative, short-lived and frequently administered due to short precorneal residence time. Here, we developed nanozyme-based exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) poly(vinyl alcohol) (PVA) overcome these problems. resultant formulation (PBnZ), which has dual-ROS scavenging abilities prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect alleviate DED. In vitro in vivo experiments revealed that PBnZ could eliminate ROS through both its multienzyme-like activity ROS-scavenging borate bonds. positively charged displayed longer time physical adhesion bonds phenyboronic acid PVA or o-diol with mucin. results showed These dual-function provide insights into novel strategies other ROS-mediated inflammatory diseases rationale application nanomaterials clinical settings. Graphical
Language: Английский
Citations
14
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Language: Английский
Citations
14
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)
Published: Feb. 26, 2024
As an indispensable part of the human sensory system, visual acuity may be impaired and even develop into irreversible blindness due to various ocular pathologies. Among diseases, fundus neovascularization diseases (FNDs) are prominent etiologies impairment worldwide. Intravitreal injection anti-vascular endothelial growth factor drugs remains primary therapy but is hurdled by common complications incomplete potency. To renovate current therapeutic modalities, nanomedicine emerged as times required, which endowed with advanced capabilities, able fulfill effective drug delivery achieve precise release control, thus further improving effect. This review provides a comprehensive summary advances in for FND management from state-of-the-art studies. First, modalities FNDs thoroughly introduced, focusing on key challenges delivery. Second, nanocarriers comprehensively reviewed posterior based nanostructures: polymer-based nanocarriers, lipid-based inorganic nanoparticles. Thirdly, characteristics microenvironment, their pathological changes during FNDs, corresponding strategies constructing smart elaborated. Furthermore, prospects discussed.
Language: Английский
Citations
10
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124192 - 124192
Published: May 3, 2024
Ocular delivery is the most challenging aspect in field of pharmaceutical research. The major hurdle for controlled drugs to eye includes physiological static barriers such as complex layers cornea, sclera and retina which restrict drug from permeating into anterior posterior segments eye. Recent years have witnessed inventions conventional nanocarrier shown considerable enhancement delivering small large molecules across dynamic challenges associated with systems include limited contact time inadequate ocular bioavailability resulting solution drainage, tear turnover, dilution or lacrimation. To this end, various bioactive-based nanosized carriers including liposomes, ethosomes, niosomes, dendrimer, nanogel, nanofibers, lenses, nanoprobes, selenium nanobells, nanosponge, polymeric micelles, silver nanoparticles, gold nanoparticles among others been developed circumvent limitations dosage forms. These nanocarriers achieve enhanced permeation retention prolong release tissue due their better adherence. surface charge size (10–1000 nm) are important key factors overcome barriers. Various deliver active therapeutic timolol maleate, ampicillin, natamycin, voriconazole, cyclosporine A, dexamethasone, moxifloxacin, fluconazole treatment diseases. Taken together, a nutshell, book chapter provides comprehensive perspective on numerous facets special focus bioactive nanocarrier-based approaches, difficulties constraints involved fabrication nanocarriers. This also detailed invention applications ophthalmic therapeutics.
Language: Английский
Citations
10
AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(5)
Published: May 10, 2024
Language: Английский
Citations
10
Nanotechnology, Journal Year: 2024, Volume and Issue: 35(13), P. 132001 - 132001
Published: Jan. 10, 2024
Abstract Chemotherapy is an important cancer treatment modality, but the clinical utility of chemotherapeutics limited by their toxic side effects, inadequate distribution and insufficient intracellular concentrations. Nanodrug delivery systems (NDDSs) have shown significant advantages in diagnosis treatment. Variable NDDSs that respond to endogenous exogenous triggers attracted much research interest. Here, we summarized nanomaterials commonly used for tumor therapy, such as peptides, liposomes, carbon nanotubes, well responses pH, enzymes, magnetic fields, light, multiple stimuli. Specifically, well-designed can change size or morphology rupture when induced one more The varying stimulation contribute molecular design development novel NDDSs, providing new ideas improving drug penetration accumulation, inhibiting resistance metastasis, enhancing immunotherapy.
Language: Английский
Citations
9
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26616 - e26616
Published: Feb. 18, 2024
A multitude of sight-threatening retinal diseases, affecting hundreds millions around the globe, lack effective pharmacological treatments due to ocular barriers and common drug delivery limitations. Polymeric nanoparticles (PNPs) are versatile carriers with sustained release profiles tunable physicochemical properties which have been explored for both anterior posterior tissues. PNPs can incorporate a wide range drugs overcome challenges conventional delivery. Moreover, be engineered respond specific stimuli such as ultraviolet, visible, or near-infrared light, allow precise spatiotemporal control release, enabling tailored treatment regimens reducing number required administrations. The objective this study is emphasize therapeutic potential light-triggered drug-loaded polymeric treat diseases through an exploration pathologies, in delivery, current production methodologies recent applications. Despite challenges, light-responsive hold promise substantially enhancing landscape aiming improved quality life patients.
Language: Английский
Citations
9