Recent Applications of PLGA in Drug Delivery Systems

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2606 - 2606

Published: Sept. 14, 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, end caps, that significantly influence release profiles degradation times. This review also covers extensive literature on application PLGA delivering small-molecule drugs, proteins, peptides, antibiotics, antiviral drugs. Furthermore, discuss role PLGA-based DDSs treating various diseases, cancer, neurological disorders, pain, inflammation. The incorporation drugs into nanoparticles microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, improve patient compliance. Overall, holds great promise for advancement treatment management multiple chronic conditions.

Language: Английский

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Cell-penetrating peptides for transmucosal delivery of proteins

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 864 - 878

Published: Jan. 27, 2024

Language: Английский

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Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment

Small, Journal Year: 2024, Volume and Issue: 20(29)

Published: Feb. 20, 2024

As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt homeostasis. Addressing these disorders requires exogenous strategies to regulate osteogenic microenvironment (OME). The regulation of OME can be divided into four processes: induction, modulation, protection, support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus nanomedicine, which show tremendous potential due their superior delivery capability. MOFs play numerous roles metal ion donors, drug carriers, nanozymes, photosensitizers, been extensively explored recent studies. This review presents comprehensive introduction by MOF-based nanomaterials. By discussing various functional MOF composites, work aims inspire guide creation sophisticated efficient nanomaterials for disease management.

Language: Английский

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Advancements in Protein-Based Bionanocomposites for Targeted and Controlled Drug Delivery Systems: A Comprehensive Review

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106698 - 106698

Published: Feb. 1, 2025

Language: Английский

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Advancing Nanotechnology: Targeting Biofilm-Forming Bacteria with Antimicrobial Peptides

BME Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Nanotechnology offers innovative solutions for addressing the challenges posed by biofilm-forming bacteria, which are highly resistant to conventional antimicrobial therapies. This review explores integration of pharmaceutical nanotechnology with peptides (AMPs) enhance treatment biofilm-related infections. The use various nanoparticle systems-including inorganic/metallic, polymeric, lipid-based, and dendrimer nanostructures-provides promising avenues improving drug delivery, targeting, biofilm disruption. These nanocarriers facilitate penetration biofilms, down-regulate biofilm-associated genes, such as ALS1, ALS3, EFG1, HWP1, inhibit bacterial defense mechanisms through membrane disruption, reactive oxygen species generation, intracellular targeting. Furthermore, formulations NZ2114-NPs demonstrate enhanced efficacy reducing counts several orders magnitude. highlights potential combining AMPs create novel, targeted therapeutic approaches combatting infections overcoming limitations traditional treatments.

Language: Английский

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Polymer-mediated protein/peptide therapeutic stabilization: Current progress and future directions

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: 156, P. 101867 - 101867

Published: Aug. 8, 2024

Language: Английский

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Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery

Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: 54(2), P. 145 - 160

Published: Feb. 8, 2024

Language: Английский

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Predicting Peptide Permeability Across Diverse Barriers: A Systematic Investigation

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(8), P. 4116 - 4127

Published: July 20, 2024

Peptide-based therapeutics hold immense promise for the treatment of various diseases. However, their effectiveness is often hampered by poor cell membrane permeability, hindering targeted intracellular delivery and oral drug development. This study addressed this challenge introducing a novel graph neural network (GNN) framework advanced machine learning algorithms to build predictive models peptide permeability. Our offer systematic evaluation across diverse peptides (natural, modified, linear cyclic) lines [Caco-2, Ralph Russ canine kidney (RRCK) parallel artificial permeability assay (PAMPA)]. The cyclic in Caco-2 RRCK were constructed first time, with an impressive coefficient determination (

Language: Английский

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Innovative cancer therapy: Unleashing the potential of macromolecule-loaded mesoporous bioactive glasses for precision diagnosis and treatment

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124847 - 124847

Published: Oct. 1, 2024

Language: Английский

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Advances in the preparation, applications, challenges, and future trends of polysaccharide‐based gels as food‐grade delivery systems for probiotics: A review

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

Abstract Probiotics are highly regarded for their multiple functions, such as regulating gut health, enhancing the immune system, and preventing chronic diseases. However, stability in harsh environments targeted release remain significant challenges. Therefore, exploring effective protection delivery strategies to ensure of probiotics is critically important. Polysaccharides, known non‐toxicity, excellent biocompatibility, superior biodegradability, show broad prospects probiotic by forming physical barriers protect probiotics. Particularly, polysaccharide‐based gels (PBGs), with unique “spider‐web” like structure, capture probiotics, significantly efficacy. This review discusses common polysaccharides used PBG preparation, classification synthesis food applications, advantages PBGs systems. Despite potential, challenges inconsistent gel properties need improved remain. Future research should focus on developing novel materials higher biodegradability mechanical strength, optimizing physicochemical cross‐linking methods, well designing multilayered structures more precise control. Additionally, co‐delivery prebiotics, active ingredients, or multi‐strain systems could further enhance efficacy delivery.

Language: Английский

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