Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 497 - 526
Published: Nov. 29, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 13, 2024
CD4 + CD25 Foxp3 regulatory T cells (Tregs), a vital component of the immune system, are responsible for maintaining homeostasis and preventing excessive responses. This review explores signaling pathways cytokines that regulate Treg cells, including transforming growth factor beta (TGF-β), interleukin (IL)-2, IL-10, IL-35, which foster differentiation enhance immunosuppressive capabilities Tregs. It also examines how, conversely, signals mediated by IL-6 tumor necrosis -alpha (TNF-α) can undermine suppressive functions or even drive their reprogramming into effector cells. The B7 family comprises indispensable co-stimulators cell activation. Among its members, this focuses on capacity CTLA-4 PD-1 to differentiation, function, survival As Tregs play an essential role in homeostasis, dysfunction contributes pathogenesis autoimmune diseases. delves potential employing Treg-based immunotherapy treatment diseases, transplant rejection, cancer. By shedding light these topics, article aims our understanding regulation therapeutic various pathological conditions.
Language: Английский
Citations
32
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132123 - 132123
Published: May 17, 2024
Language: Английский
Citations
18
Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(10), P. 105968 - 105968
Published: Aug. 17, 2024
Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.
Language: Английский
Citations
18
Nanoscale, Journal Year: 2024, Volume and Issue: 16(35), P. 16313 - 16328
Published: Jan. 1, 2024
Carbon materials and their hybrid metal composites have garnered significant attention in biomedical applications due to exceptional biocompatibility.
Language: Английский
Citations
9
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 181, P. 46 - 66
Published: April 30, 2024
Skeletal muscle is a pro-regenerative tissue, that utilizes tissue-resident stem cell system to effect repair upon injury. Despite the demonstrated efficiency of this in restoring mass after many acute injuries, conditions severe trauma such as those evident volumetric loss (VML) (>20% by mass), self-repair capability unable restore tissue architecture, requiring interventions which currently are largely surgical. As possible alternative, generation artificial using engineering approaches may also be importance treatment VML and diseases dystrophies. Three-dimensional (3D) bioprinting has been identified promising technique for regeneration complex architecture skeletal muscle. This review discusses existing strategies following damage, recent progress techniques, bioinks used regeneration, immunogenicity scaffold materials, vitro vivo maturation techniques 3D bio-printed constructs. The pros cons these bioink formulations highlighted. Finally, we present current limitations challenges field critical factors consider become more translational produce clinically relevant engineered physiopathology injuries clinical types have applied muscle, commonly regeneration. We discussion gaps literature translation provide insights into what believe will next steps required before realization application tissue-engineered humans. manuscript an insightful, timely, instructive guide future research from fundamental construct creation approach, down pathway achieve desired impact clinic.
Language: Английский
Citations
7
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101342 - 101342
Published: Nov. 14, 2024
Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility biodegradability, closely resemble living tissues. The versatility hydrogels has fuelled application in various fields, agriculture, biomaterials, the food industry, drug delivery, tissue engineering, regenerative medicine. combination nanoparticles, specifically Mesoporous Silica Nanoparticles (MSNs), have elevated these composites to next level, since MSNs could improve hydrogel mechanical ability encapsulate controlled release great amounts different therapeutic agents, responsiveness a variety external internal stimuli. In this review, main features both introduced, followed by discussion hydrogels-MSNs structures an overview use applications, delivery technologies engineering.
Language: Английский
Citations
4
Biomaterials Research, Journal Year: 2025, Volume and Issue: 29
Published: Jan. 1, 2025
Exosomes (Exos) are tiny extracellular vesicles containing a variety of active biomolecules that play important parts in intercellular communication and influence the functions target cells. The potential Exos treatment dermatological diseases has recently been well appreciated. This review highlights constituents, function, delivery Exos, with particular focus on their applications skin therapy. Firstly, we offer concise overview biochemical properties including sources, structures, internal constituents. Subsequently, biomedical latest advances extraction purification summarized. We further discuss modes underscore biomaterials this regard. Finally, summarize application Exo-aided therapy dermatology. Overall, objective is to provide comprehensive perspective recent advancements Exo-based approaches treating diseases, intention guiding future research efforts.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3874 - 3874
Published: April 19, 2025
Spinal cord injury (SCI) remains a major clinical challenge, with limited therapeutic options for restoring lost neurological function. While efforts to mitigate secondary damage have improved early-phase management, achieving sustained neurorepair and functional recovery elusive. Advances in stem cell engineering regenerative medicine opened new avenues targeted interventions, particularly through the transplantation of neural stem/progenitor cells (NSPCs), induced pluripotent (iPSCs), mesenchymal (MSCs). However, patient-specific factors such as cellular senescence, genetic epigenetic variability, microenvironment, comorbidities influence efficacy therapies by affecting graft survival differentiation. Overcoming these challenges necessitates cutting-edge technologies, including single-cell transcriptomics, CRISPR-mediated hypoimmunogenic engineering, biomaterial-based delivery platforms, which enable personalized precision-driven SCI repair. Leveraging advancements may help overcome translational barriers establish clinically viable solutions. This review explores intersection bioengineering innovations, transcriptomic-guided precision define next frontier therapy.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 22, 2025
Metabolic syndrome (MetS) is a group of symptoms that are characterized by abnormal changes in metabolic substances such as glucose, lipids, proteins, and bile acids. MetS common complication after organ transplantation can further affect the survival physiological function graft reprograming patient's immune environment. Additionally, influence occurrence post-transplant complications, infections. In recent years, research into epidemiology mechanisms has grown significantly. this review, we summarize hyperglycemia, insulin resistance, hyperlipidemia, acids, amino acids on body's cells related to effect disorders rejection liver, kidney, heart, skin other transplantation. Finally, provide an overview current treatment strategies offer insights potential future therapies for managing transplant recipients.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 18, 2023
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes (T1DM) results from insufficient insulin secretion islets; its treatment requires lifelong use of injections, which leads to large economic burden on patients. Islet transplantation may be promising effective for T1DM. Clinically, this process currently involves directly infusing islet cells into the hepatic portal vein; however, at site often elicits immediate blood-mediated inflammatory and acute immune responses. Subcutaneous an attractive alternative because simpler, demonstrates lower surgical complication risks, enables graft monitoring removal. In article, we review current methods subcutaneous device-free transplantation. Recent techniques with success rate have involved bioengineering technology biomaterial cotransplantation—including cell growth factor co-transplantation hydrogel– or simulated extracellular matrix–wrapped co-transplantation. general, modalities can simplify improve posttransplantation survival rate, thus aiding T1DM management.
Language: Английский
Citations
7