Technology and Health Care, Journal Year: 2024, Volume and Issue: 32, P. 523 - 542
Published: May 14, 2024
Colon cancer is the most prevalent and rapidly increasing malignancy globally. It has been suggested that some of ingredients in herb pair Coptidis Rhizoma ginger (Zingiber officinale), a traditional Chinese medicine, have potential anti-colon properties.
Language: Английский
Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1754 - 1754
Published: June 3, 2024
Dietary intake of natural substances to regulate physiological functions is currently regarded as a potential way promoting health. As one the recommended dietary ingredients, phytosterols that are bioactive compounds distributed in plants have received increasing attention for their health effects. Phytosterols attracted great from scientists because many functions, example, cholesterol-lowering, anticancer, anti-inflammatory, and immunomodulatory In addition, phytosterols, purification, structure analysis, synthesis, food application been widely studied. Nowadays, bioactivities assessed vivo vitro. However, mechanisms pharmacological activities not yet fully understood, in-depth investigation relationship between function crucial. Therefore, contemporaneous overview extraction, beneficial properties, mechanisms, well current states phytosterol application, field provided this review.
Language: Английский
Citations
12
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 214, P. 137 - 157
Published: Feb. 15, 2024
The exploration of drugs derived from natural sources holds significant promise in addressing current limitations ovarian cancer (OC) treatments. While previous studies have highlighted the remarkable anti-cancer properties compound β-sitosterol (SIT) across various tumors, its specific role OC treatment remains unexplored. This study aims to investigate anti-tumor activity SIT using vitro and vivo models, delineate potential mechanisms, establish a preclinical theoretical foundation for future clinical trials, thus fostering further research. Utilizing network pharmacology, we pinpoint as promising candidate predict targets pathways. Through series experiments, unveil novel mechanism through which mitigates malignant biological behaviors cells by modulating redox status. Specifically, selectively argininosuccinate synthetase 1 (ASS1), protein markedly overexpressed tissues cells. Inhibiting ASS1, enhances interaction between Nrf2 Keap1, instigating ubiquitin-dependent degradation Nrf2, subsequently diminishing transcriptional activation downstream antioxidant genes HO-1 NQO1. interruption program results substantial accumulation reactive oxygen species (ROS) This, turn, upregulates PTEN, exerting negative regulation on phosphorylation AKT. suppression AKT signaling disrupted pathways associated with cell cycle, survival, apoptosis, migration, invasion, ultimately culminating death Our research uncovers new mechanisms against OC, contributing existing knowledge effects products context OC. Additionally, this unveils ASS1 regulating Nrf2-mediated governing homeostasis providing deeper understanding complex disease.
Language: Английский
Citations
11
Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(3)
Published: Feb. 7, 2025
Artemisia campestris subsp. (tuguft) is a medicinal plant traditionally used in Algerian medicine. This study investigates the chemical composition and bioactivity of its essential oil (ACEO). Gas chromatography-mass spectrometry (GC-MS) analysis identified key compounds, including linalyl acetate (2.92%), geranyl (2.45%), eucalyptol (1.38%). ACEO demonstrated significant antioxidant activity, with IC50 values 11.09 μg/mL (DPPH), 15.81 (FRAP), 22.70 (β-carotene). It also enhanced peroxidase activity by 82.67 U/g. The anti-inflammatory effects were confirmed an 18.87 μg/mL. Notably, silico molecular docking revealed that 3-cyclopentyl-N-(2-(3,4-dimethoxyphenyl)ethyl) exhibits strong binding affinity to phosphoinositide 3-kinase gamma, target for pancreatic cancer therapy, suggesting potential anticancer activity. These findings underscore therapeutic ACEO, highlighting antioxidant, anti-inflammatory, properties.
Language: Английский
Citations
1
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(2), P. 592 - 619
Published: Nov. 6, 2023
Abstract Sterols, including β‐sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol various materials, comprehensive scientific knowledge regarding the properties β‐sitosterol its potential applications is for scholarly pursuits utilization purposes. shares similar chemical characteristics with cholesterol exhibits several pharmacological activities without toxicity. This study aims to bridge gap between phytochemistry current evidence focusing on anticancer activity other biomedical properties. The goal provide understanding β‐sitosterol's future translational approaches. A thorough examination literature was conducted gather relevant information biological particularly therapeutic potential. Various databases were searched, PubMed/MedLine, Scopus, Google Scholar, Web Science using appropriate keywords. Studies investigating effects different types cancer analyzed, mechanisms action, screening, chemosensitizing Modern screening studies have revealed against cancer, leukemia, lung, stomach, breast, colon, ovarian, prostate cancer. has demonstrated cells, interfering multiple cell signaling pathways involved proliferation, cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, inflammation. Structural derivatives also shown anti‐cancer effects. However, research field drug delivery detailed mode action β‐sitosterol‐mediated remains limited. as non‐toxic compound significant potential, promising types. relatively less potent than conventional chemotherapeutics, holds safe effective nutraceutical Further recommended explore develop novel formulations use treatment. review provides foundation investigations highlights need further superfood combating
Language: Английский
Citations
18
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116592 - 116592
Published: April 13, 2024
Multiple epigenetic factors play a regulatory role in maintaining the homeostasis of cutaneous components and are implicated aging process skin. They have been associated with activation senescence program, which is primary contributor to age-related decline Senescent species drive series interconnected processes that impact immediate surroundings, leading structural changes, diminished functionality, heightened vulnerability infections. Geroprotective medicines may restore balance represent valid therapeutic alliances against skin aging. Most them well-known Western medications such as metformin, nicotinamide adenine dinucleotide (NAD+), rapamycin, histone deacetylase inhibitors, while others belong Traditional Chinese Medicine (TCM) remedies for scientific literature provides limited information. With help Geroprotectors.org database comprehensive analysis referenced literature, we compiled data on compounds formulae shown potential preventing identified modulators.
Language: Английский
Citations
7
CyTA - Journal of Food, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 17, 2024
β-sitosterol is waxy substance, white in color distributed a variety of natural plant sources cereals, pulses, legumes, vegetables, fruits, and herbs. Several clinical preclinical investigations indicate that has wide range important health advantages. It prevents many types malignancies, lowers levels low density lipoprotein (LDL), the risk coronary artery disease, heart attacks, atherosclerosis, supports body's healing process. found to have cancer-protective properties potency be beneficial against breast, prostate, colon, lung, stomach, leukemia. The present review provides complete analysis examines literature on from different dietary sources, with focus its toxicological characteristics nutraceutical qualities. lays down theoretical basis justification for directing future planning execution studies intended confirm importance possible toxicity β-sitosterol.
Language: Английский
Citations
6
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)
Published: Dec. 4, 2023
Abstract Background Glioblastoma (GBM) is the most common primary malignant tumor in central nervous system. Paclitaxel (PTX) a well‐established and highly effective anti‐cancer drug for peripheral solid tumors. However, application of PTX GBM hindered by several limitations, including poor water solubility, restricted entry across blood–brain barrier (BBB), enhanced excretion efflux transporters. P‐glycoprotein (P‐gp) crucial transporter that abundantly present cerebral vascular endothelial cells cells. It plays significant role exocytosis within tissues. Methods Recently, we have developed novel technique creating self‐assembled nanoparticles utilizing range natural bioactive molecules. These can encapsulate insoluble drugs effectively cross BBB. In additional, revealed certain potential to act as P‐gp inhibitors, thereby reducing PTX. this study, conducted screening molecular identify those inhibit function Results Among candidates, identified ursolic acid (UA NPs) inhibitors. Furthermore, prepared co‐assembled UA NPs embedded with paclitaxel, referred UA‐PTX NPs. Our results demonstrate enhance blood concentration PTX, facilitate its into BBB, P‐gp, resulting decrease This discovery addressed above three issues associated use glioma treatment. Conclusions strong anti‐tumor effects show great treating GBM.
Language: Английский
Citations
16
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 999 - 999
Published: Jan. 13, 2024
Gastrointestinal cancers are a major global health challenge, with high mortality rates. This study investigated the anti-cancer activities of 30 monomers extracted from Morus alba L. (mulberry) against gastrointestinal cancers. Toxicological assessments revealed that most compounds, particularly immunotoxicity, exhibit some level toxicity, but it is generally not life-threatening under normal conditions. Among these components, Sanggenol L, Sanggenon C, Kuwanon H, 3′-Geranyl-3-prenyl-5,7,2′,4′-tetrahydroxyflavone, Morusinol, Mulberrin, Moracin P, E, and A demonstrate significant properties various cancers, including colon, pancreatic, gastric The mechanism chemical components was explored in cancer cells, revealing they inhibit cell cycle DNA replication-related gene expression, leading to effective suppression tumor growth. Additionally, induced unfolded protein response (UPR) endoplasmic reticulum (ER) stress, potentially resulting damage, autophagy, death. an active monomer characterized as 2-arylbenzofuran, found induce ER stress promote apoptosis confirming its potential growth vitro vivo. These findings highlight therapeutic especially focusing on P potent inducer apoptosis.
Language: Английский
Citations
5
Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 33 - 42
Published: Jan. 1, 2025
Objective: Chronic pain strongly affects the quality of life patients with liver cancer pain. Safe and effective management cancer-related is a worldwide challenge. Traditional Chinese medicine (TCM) has rich clinical experience in treatment The Fuzhengxiaoliu patch (FZXLP) compound TCM effects detoxification relief shown great efficacy cancer, but high-quality research that provides research-based evidence lacking. We designed randomized, double-blind, placebo-controlled trial to explore evaluate FZXLP for Methods: This prospective, trial. will enrol 72 participants primary (damp-heat stagnation toxin blood stasis syndrome). objective measure reduction using combination tegafur, gimeracil oteracil potassium capsule (S-1) compared placebo group S-1. Pain be measured by number opioids used, versions numerical rating scale (NRS), rate breakthrough cases (BTcP). secondary objectives include response evaluation criteria solid tumors (RECIST), tumor markers, syndrome scores, weight, functional assessment therapy-hepatobiliary (FACT-Hep) questionnaire self-rating anxiety scores. Adverse events (AEs) recorded throughout study. Discussion: study integrated assess safety addition Trial registration: registry, ChiCTR2300076951, Registered on October 25, 2023. https://www.chictr.org.cn/showproj.html?proj=209608 . Keywords: traditional medicine, herb, management, randomized controlled
Language: Английский
Citations
0
Acta Histochemica, Journal Year: 2025, Volume and Issue: 127(1), P. 152230 - 152230
Published: Jan. 16, 2025
Language: Английский
Citations
0