Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

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Immune Modulation in Alzheimer’s Disease: From Pathogenesis to Immunotherapy

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 264 - 264

Published: Feb. 12, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting significant proportion elderly population. AD characterized by cognitive decline functional impairments due to pathological hallmarks like amyloid β-peptide (Aβ) plaques neurofibrillary tangles (NFTs) composed hyperphosphorylated tau. Microglial activation, chronic neuroinflammation, disruptions in neuronal communication further exacerbate disease. Emerging research suggests that immune modulation could play key role treatment given involvement neuroinflammatory processes. This review focuses on recent advancements immunotherapy strategies aimed at modulating responses AD, with specific emphasis microglial behavior, clearance, tau pathology. By exploring these immunotherapeutic approaches, we aim provide insights into their potential alter progression improve patient outcomes, contributing evolving landscape treatment.

Language: Английский

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Probiotics: Bridging the interplay of a healthy gut and psychoneurological well‐being

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147

Published: March 1, 2024

Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.

Language: Английский

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The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.

Language: Английский

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Novelties on Neuroinflammation in Alzheimer’s Disease–Focus on Gut and Oral Microbiota Involvement

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11272 - 11272

Published: Oct. 19, 2024

Recent studies underscore the role of gut and oral microbiota in influencing neuroinflammation through microbiota–gut–brain axis, including Alzheimer’s disease (AD). This review aims to provide a comprehensive synthesis recent findings on involvement neuroinflammatory processes associated with AD, emphasizing novel insights therapeutic implications. reveals that dysbiosis AD patients’ is linked heightened peripheral central inflammatory responses. Specific bacterial taxa, such as Bacteroides Firmicutes gut, well Porphyromonas gingivalis cavity, are notably altered leading significant changes microglial activation cytokine production. Gut alterations increased intestinal permeability, facilitating translocation endotoxins like lipopolysaccharides (LPS) into bloodstream exacerbating by activating brain’s toll-like receptor 4 (TLR4) pathways. Furthermore, microbiota-derived metabolites, short-chain fatty acids (SCFAs) amyloid peptides, can cross blood-brain barrier modulate While microbial amyloids may contribute amyloid-beta aggregation brain, certain SCFAs butyrate exhibit anti-inflammatory properties, suggesting potential avenue mitigate neuroinflammation. not only highlights critical pathology but also offers ray hope modulating could represent strategy for reducing slowing progression.

Language: Английский

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Gut Microbiota and Immune System Dynamics in Parkinson’s and Alzheimer’s Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12164 - 12164

Published: Nov. 13, 2024

The gut microbiota, a diverse collection of microorganisms in the gastrointestinal tract, plays critical role regulating metabolic, immune, and cognitive functions. Disruptions composition these microbial communities, termed dysbiosis, have been linked to various neurodegenerative diseases (NDs), such as Parkinson's disease (PD) Alzheimer's (AD). One key pathological features NDs is neuroinflammation, which involves activation microglia peripheral immune cells. microbiota modulates responses through production metabolites interactions with cells, influencing inflammatory processes within central nervous system. This review explores impact dysbiosis on focusing roles microglia, potential therapeutic strategies targeting alleviate neuroinflammatory NDs.

Language: Английский

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Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer’s Disease in Experimental Rats

Assay and Drug Development Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Alzheimer's disease (AD) is a neurological disorder that results in the loss of memory and cognitive functions linked to redox disbalance, neuroinflammation, neurotransmitters changes, accumulation amyloid-beta (1–42) plaques AD. In this study, rats were administered with intracerebroventricular (ICV) streptozotocin (STZ) produce AD-like symptoms rats. ICV-STZ bilaterally, 3 mg/kg, was infused on days 1 help Hamilton syringe by fixing cannula at target position rat brain using coordinates −2 mm (anteriposterior), 1.6 Mediolateral (ML), 1.5 (dorsoventral). Learning spatial checked Morris water maze elevated plus apparatus. ICV-STZ, lost their learning memory, increased level prooxidant like Lipid peroxidation (LPO), nitrite reduced glutathione (GSH), catalase, superoxide dismutase (SOD) level. The acetylcholinesterase (AChE) catalyzed acetylcholine (ACh) concentration indicates cholinergic neuron degeneration. Furthermore, we found raised inflammatory markers altered after ICV-STZ. Administration aescin (10, 20, 30 p.o.) dose-dependently ameliorated behavioral alteration inhibited tumor necrosis factor-alpha, interleukin-6 (IL-6), IL-1β. restored antioxidants GSH, SOD, catalase lipid AChE enzyme causes degradation ACh, its declined treatment aescin. Aescin also GABA, norepinephrine, serotonin prevention glutamate Moreover, histopathological study confirmed neuronal pathogenesis, significantly achieved neuroprotective effect via preventing balancing potential, inhibiting enzyme.

Language: Английский

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Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Butyrate: a key mediator of gut-brain communication in Alzheimer’s disease

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(5)

Published: April 23, 2025

Language: Английский

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Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer’s disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut–brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood–brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

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