Analysis of the Associations of Measurements of Body Composition and Inflammatory Factors with Cardiovascular Disease and Its Comorbidities in a Community-Based Study DOI Creative Commons
Nader Tarabeih, Alexander Kalinkovich, Shai Ashkenazi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1066 - 1066

Published: May 11, 2024

The associations of cardiovascular disease (CVD) with comorbidities and biochemical body composition measurements are repeatedly described but have not been studied simultaneously. In the present cross-sectional study, information on CVD [type 2 diabetes mellitus (T2DM), hypertension (HTN), hyperlipidemia (HDL)], composition, levels soluble markers, other measures were collected from 1079 individuals. When we examined association each comorbidity CVD, controlling for comorbidities, observed a clear pattern comorbidity-related specific tested covariates. For example, T2DM was significantly associated GDF-15 leptin/adiponectin (L/A) ratio independently two comorbidities; HTN, similarly, extracellular water (ECW) levels, L/A ratio, age; HDL related to age only. showed very strong independent being most strongly HTN (OR = 10.89, 6.46–18.38) also (2.49, 1.43–4.33) (1.93, 1.12–3.33). An additive Bayesian network analysis suggests that all three particularly ECW content, likely main role in risk development. Other factors, lymphocyte count, systemic inflammation response index, indirectly acting through ECW.

Language: Английский

World Heart Federation Roadmap for Secondary Prevention of Cardiovascular Disease: 2023 Update DOI Creative Commons
Liliana Laranjo, Fernando Laņas, Marie Chan Sun

et al.

Global Heart, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Background: Secondary prevention lifestyle and pharmacological treatment of atherosclerotic cardiovascular disease (ASCVD) reduce a high proportion recurrent events mortality. However, significant gaps exist between guideline recommendations usual clinical practice. Objectives: Describe the state art, roadblocks, successful strategies to overcome them in ASCVD secondary management. Methods: A writing group reviewed guidelines research papers received inputs from an international committee composed health systems experts about article's structure, content, draft. Finally, external expert paper. Results: Smoking cessation, physical activity, diet weight management, antiplatelets, statins, beta-blockers, renin-angiotensin-aldosterone system inhibitors, cardiac rehabilitation Potential roadblocks may occur at individual, healthcare provider, levels include lack access medicines, inertia, primary care infrastructure or built environments that support preventive behaviours. Possible solutions improving literacy, self-management strategies, national policies improve medication (including fix-dose combination therapy), implementing programs, incorporating digital interventions. Digital tools are being examined range settings enhancing self-management, risk factor control, rehab. Conclusions: Effective for management exist, but there barriers their implementation. WHF roadmaps can facilitate development strategic plan identify implement local level approaches prevention.

Language: Английский

Citations

35
Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024 DOI Creative Commons
Harold Bays, Carol F. Kirkpatrick, Kevin C. Maki

et al.

Journal of clinical lipidology, Journal Year: 2024, Volume and Issue: 18(3), P. e320 - e350

Published: April 24, 2024

BACKGROUNDThis joint expert review by the Obesity Medicine Association (OMA) and National Lipid (NLA) provides clinicians an overview of pathophysiologic clinical considerations regarding obesity, dyslipidemia, cardiovascular disease (CVD) risk.METHODSThis is based upon scientific evidence, perspectives authors, peer OMA NLA leadership.RESULTSAmong individuals with adipose tissue may store over 50% total body free cholesterol. Triglycerides represent up to 99% lipid species in tissue. The potential for expansion accounts greatest weight variance among most individuals, percent fat ranging from less than 5% 60%. While population studies suggest a modest increase blood low-density lipoprotein cholesterol (LDL-C) levels excess adiposity, adiposopathic dyslipidemia pattern often described adiposity includes elevated triglycerides, reduced high density (HDL-C), increased non-HDL-C, apolipoprotein B, LDL particle concentration, small, dense particles.CONCLUSIONSObesity increases CVD risk, at least partially due promotion adiposopathic, atherogenic profile. also worsens other cardiometabolic risk factors. Among patients interventions that reduce improve outcomes are generally associated improved levels. Given improvement LDL-C reduction overweight or early treat both (LDL-C and/or non-HDL-C) priorities reducing CVD. This risk. leadership. particles.

Language: Английский

Citations

27
Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024 DOI Creative Commons
Harold Bays, Carol F. Kirkpatrick, Kevin C. Maki

et al.

Obesity Pillars, Journal Year: 2024, Volume and Issue: 10, P. 100108 - 100108

Published: March 12, 2024

This joint expert review by the Obesity Medicine Association (OMA) and National Lipid (NLA) provides clinicians an overview of pathophysiologic clinical considerations regarding obesity, dyslipidemia, cardiovascular disease (CVD) risk. is based upon scientific evidence, perspectives authors, peer OMA NLA leadership. Among individuals with adipose tissue may store over 50% total body free cholesterol. Triglycerides represent up to 99% lipid species in tissue. The potential for expansion accounts greatest weight variance among most individuals, percent fat ranging from less than 5% 60%. While population studies suggest a modest increase blood low-density lipoprotein cholesterol (LDL-C) levels excess adiposity, adiposopathic dyslipidemia pattern often described adiposity includes elevated triglycerides, reduced high density (HDL-C), increased non-HDL-C, apolipoprotein B, LDL particle concentration, small, dense particles. increases CVD risk, at least partially due promotion adiposopathic, atherogenic profile. also worsens other cardiometabolic risk factors. patients interventions that reduce improve outcomes are generally associated improved levels. Given improvement LDL-C reduction overweight or early treat both (LDL-C and/or non-HDL-C) priorities reducing CVD.

Language: Английский

Citations

19
Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases? DOI Creative Commons
Elena Domingo, Patrice Marqués, Vera Francisco

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 200, P. 107058 - 107058

Published: Jan. 11, 2024

Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide. While many factors can contribute to CVD, atherosclerosis is cardinal underlying pathology, its development associated with several metabolic risk including dyslipidemia obesity. Recent studies have definitively demonstrated a link between low-grade systemic inflammation two relevant abnormalities: hypercholesterolemia Interestingly, both disorders are also endothelial dysfunction/activation, proinflammatory prothrombotic phenotype endothelium that involves leukocyte infiltration into arterial wall, one earliest stages atherogenesis. This article reviews current literature on intricate relationship obesity dysfunction, discusses effectiveness present, emerging in-development pharmacological therapies used treat these focus their effects inflammatory state cardiovascular risk.

Language: Английский

Citations

11
Defining preventive cardiology: A clinical practice statement from the American Society for Preventive Cardiology DOI Creative Commons
Charles German, Seth J. Baum, Keith C. Ferdinand

et al.

American Journal of Preventive Cardiology, Journal Year: 2022, Volume and Issue: 12, P. 100432 - 100432

Published: Nov. 16, 2022

Remarkable transformations in science and healthcare have resulted declines mortality from cardiovascular disease over the past several decades, largely driven by progress prevention treatment of persons at risk. However, these trends are now beginning to stall, as our county faces increases risk factors including overweight obesity, type 2 diabetes mellitus, metabolic syndrome. Furthermore, poor long-term adherence a healthy lifestyle lifesaving pharmacotherapy exacerbated trends, with recent data suggesting unprecedented morbidity mortality. A paradigm shift is needed improve health nation. Preventive cardiology, growing subspecialty medicine, practice primordial, primary, secondary all diseases. cardiologists preventive cardiology specialists well equipped knowledge skill-set necessary reduce deaths related burden heart its factors. Despite dedicated efforts, remains leading killer men women United States. Although there little debate regarding importance prevention, many professionals question need for distinct subspecialty. Additionally, field's growth has been hampered lack organization standardization, variability training within programs across country. The purpose this document delineate key attributes that define field according American Society Cardiology.

Language: Английский

Citations

32
Obesity and hypertension: Obesity medicine association (OMA) clinical practice statement (CPS) 2023 DOI Creative Commons

Tiffany Lowe Clayton,

Angela Fitch, Harold Bays

et al.

Obesity Pillars, Journal Year: 2023, Volume and Issue: 8, P. 100083 - 100083

Published: Aug. 7, 2023

This Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) provides an overview of the mechanisms and treatment obesity hypertension.

Language: Английский

Citations

18
Electrochemical immunosensor based on ferrocene derivatives amplified signal for detection of acute myocardial infarction warning biomarker-cTnI DOI
Bolu Sun,

Liangrong Bao,

Yanlei Sun

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 199, P. 110057 - 110057

Published: Jan. 29, 2024

Language: Английский

Citations

5
Serum Inflammatory Markers Used in Cardiovascular Disease Risk Prediction Models: A Systematic Review DOI

Sofia-Panagiota Giannakopoulou,

Alexios S. Antonopoulos, Demosthenes B. Panagiotakos

et al.

Angiology, Journal Year: 2024, Volume and Issue: unknown

Published: March 14, 2024

The aim of this review was to perform a critical appraisal serum inflammatory biomarkers used for the prediction cardiovascular disease (CVD) risk. We conducted systematic studies listed on MEDLINE and Scopus from January 2000 December 2023, focused prognostic value [i.e., C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] in individuals without known CVD. Eligible multivariate model included discrimination or risk reclassification analysis. Quality Prognostic Studies (QUIPS) tool evaluate study quality potential bias. Thirty-five (i.e., total 208,897 participants) that evaluated added CRP, IL-6, TNF-α CVD were retrieved. Significant improvements model's predictive ability observed 7 out 32 relating CRP 1 8 IL-6 with single found no use model. integration into models does not appear improve models, suggesting these may act as surrogate markers, but predictors atherosclerotic

Language: Английский

Citations

5
Dietary copper intake and risk of myocardial infarction in US adults: A propensity score-matched analysis DOI Creative Commons

He Wen,

Xiaona Niu, Lang Hu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 10, 2022

Objectives Most studies have examined the association between serum copper and myocardial infarction, but there is little evidence of dietary intake infarction. Materials methods The study included a total 14,876 participants from 2011 to 2018 National Health Nutrition Examination Survey (NHANES). Multivariate logistic regression model was used analyze risk To reduce selection bias, we use nearest neighbor propensity score matching (PSM) in 1:2 ratio. Restricted cubic spline (RCS) method non-linear relationship. Subgroup stratification further investigate Results median 1.0825 mg/day. A infarction had occurred approximately 4.4% (655) participants. Before after matching, multivariate models revealed negative correlation higher quartile subjects noticeably lower comparison those first intake. According RCS findings, dose-response stratified analysis, substantial protective element for who were ≥ 50 years old, female, 25 ≤BMI <30, with history smoking, hypertension, diabetes ortholiposis. Conclusion Increased associated It especially significant elderly-aged women, overweight individuals, smokers, diabetic patients.

Language: Английский

Citations

19
Validation of the SCORE2 risk prediction algorithm in a Portuguese population: A new model to estimate 10-year cardiovascular disease incidence in Europe DOI Creative Commons
M Temtem, M I Mendonça, M Santos

et al.

Revista Portuguesa de Cardiologia, Journal Year: 2024, Volume and Issue: 43(8), P. 437 - 444

Published: Feb. 21, 2024

Subjects without cardiovascular (CV) disease (CVD) may suffer from subclinical atherosclerosis, and are at increased risk for atherosclerotic CV events (ASCVE). The ESC/EAS SCORE was updated by SCORE2, which estimates 10-year of fatal non-fatal CVD in European populations aged 40-69 years established or diabetes. Our aim to compare the two scores validate SCORE2 our population.

Language: Английский

Citations

4