Materials Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The pursuit of effective drug delivery systems is critical in advancing cancer therapies, particularly the realms chemotherapy, radiotherapy and immunotherapy.
Language: Английский
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 1127 - 1149
Published: Dec. 26, 2022
Language: Английский
Citations
170
Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 20(1)
Published: May 23, 2022
Abstract Background Many eukaryote cells produce membrane-enclosed extracellular vesicles (EVs) to establish cell-to-cell communication. Plant-derived EVs (P-EVs) contain proteins, RNAs, lipids, and other metabolites that can be isolated from the juice, flesh, roots of many species. Methods In present review study, we studied numerous articles over past two decades published on role P-EVs in plant physiology as well application these different diseases. Results Different types have been identified plants multiple functions including reorganization cell structure, development, facilitating crosstalk between fungi, immunity, defense against pathogens. Purified several edible species, are more biocompatible, biodegradable, extremely available plants, making them useful for cell-free therapy. Emerging evidence clinical preclinical studies suggest benefits conventional synthetic carriers, opening novel frontiers drug-delivery system. Exciting new opportunities, designing drug-loaded improve systems, already being examined, however translation P-EVs-based therapies faces challenges. Conclusion hold great promise treatment addition, despite enthusiastic results, further scrutiny should focus unravelling detailed mechanism behind biogenesis trafficking their therapeutic applications.
Language: Английский
Citations
155
Pharmacological Research, Journal Year: 2023, Volume and Issue: 190, P. 106733 - 106733
Published: March 15, 2023
Natural compounds are widely used to prevent and treat various diseases due their antioxidant anti-inflammatory effects. As a kind of promising natural compound, plant-derived exosome-like nanoparticles (PELNs) extracted from multivesicular bodies edible plants, including vegetables, foods, fruits, mainly regulate the cellular immune response pathogen attacks. Moreover, PELNs could remarkably interfere with dynamic imbalance between pro-inflammatory effects, facilitating maintain homeostasis microenvironment. may serve as better alternative animal-derived exosomes (ADEs) owing widespread sources, cost-effectiveness, easy accessibility. can mediate interspecies communication by transferring cargoes such proteins, lipids, nucleic acids plant cells mammalian cells. This review summarizes biogenesis, composition, classification exosomes; common separation, purification, characterization methods PELNs, potential advantages over ADEs; immunomodulatory functions in colitis, cancer, inflammation-associated metabolic diseases. Additionally, future perspectives challenges associated clinical application discussed.
Language: Английский
Citations
87
Nano Today, Journal Year: 2023, Volume and Issue: 49, P. 101771 - 101771
Published: Feb. 7, 2023
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the plasma membrane fuse released into surrounding body fluids. They best known for their multifunction in mediating intercellular communication by transferring various biomolecules, including DNA, RNAs, proteins, lipids, a short- long-distance manner have been identified as health disease messengers. Importantly, exosomes necessary physiological processes disease. The generation of depends on status disease, which usually exhibits opposite roles inducing enhanced cellular stress damage. Recently, exosome-based nanotechnologies provided unprecedented opportunities to boost developments exosome-related biology, chemistry, pathology, therapeutics different diseases based unique structural/compositional/morphological characteristics next-generation nanomedicines. Herein, we provide comprehensive overview recent advances exosome nanotechnology research, classification, isolation preparation, constitution, biological function, nanobiomedical applications treatment diagnosis. Furthermore, future prospects were also concluded. This review will more inspiration promoting development advanced theranostic nanoplatforms nanotechnology.
Language: Английский
Citations
84
Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(4), P. 836 - 849
Published: April 1, 2024
Abstract Exosomes, which are nanosized vesicles secreted by cells, attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capacity, and deep tissue penetration. They serve as natural signaling agents intercellular communication, inherent ability carry proteins, lipids, nucleic acids endows them with remarkable therapeutic potential. Thus, exosomes can be exploited for diverse applications, chemotherapy, gene therapy, photothermal therapy. Moreover, capacity homotypic targeting self-recognition provides opportunities personalized medicine. Despite advantages novel agents, there several challenges optimizing efficiency structural stability defining exosome origins. Future should include development large-scale, quality-controllable production methods, refinement drug strategies, extensive vivo studies clinical trials. unresolved difficulties, use efficient, stable, safe delivery systems is an interesting area research. Therefore, this review describes summarizes cutting-edge published high-impact journals that have introduced or enhanced effects using a system past 2 years. We provide informative overview current state research, highlighting properties applications exosomes. also emphasize future directions, underscoring importance addressing key issues field. With review, we encourage researchers further develop exosome-based drugs application, such may among most promising next-generation therapeutics.
Language: Английский
Citations
76
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4987 - 5009
Published: Sept. 1, 2023
Abstract: Exosomes are small extracellular vesicles, ranging in size from 30– 150nm, which can be derived various types of cells. In recent years, mammalian-derived exosomes have been extensively studied and found to play a crucial role regulating intercellular communication, thereby influencing the development progression numerous diseases. Traditional Chinese medicine has employed plant-based remedies for thousands an increasing body evidence suggests that plant-derived exosome-like nanovesicles (PELNs) share similarities with terms their structure function. this review, we provide overview advances study PELNs potential implications human health. Specifically, summarize roles respiratory, digestive, circulatory, other Furthermore, investigated shortcomings challenges current research regarding mechanism action, safety, administration routes, isolation extraction methods, characterization identification techniques, as well drug-loading capabilities. Based on these considerations, propose recommendations future directions. Overall, our review highlights promising area research, broad treatment We anticipate continued interest hope summary findings will stimulate further exploration into Keywords: exosomes, nanocarriers, nanotherapeutics, plants, vesicles
Language: Английский
Citations
75
MedComm, Journal Year: 2023, Volume and Issue: 4(4)
Published: June 17, 2023
Abstract Regeneration is a complex process affected by many elements independent or combined, including inflammation, proliferation, and tissue remodeling. Stem cells class of primitive with the potentiality differentiation, regenerate self‐replication, multidirectional immunomodulatory functions. their cytokines not only inextricably linked to regeneration ectodermal skin tissues, but also can be used for treatment variety chronic wounds. produce exosomes in paracrine manner. cell play an important role regeneration, repair, accelerated wound healing, biological properties which are similar stem cells, while safer more effective. Skin bone tissues critical organs body, essential sustaining life activities. The weak repairing ability leads pronounced impact on quality patients, could alleviated treatment. However, there obstacles that trough improved bioavailability. This paper summarizes applications mechanisms healing. We propose new ways utilizing through different nanoformulations, liposomes nanoliposomes, polymer micelles, microspheres, hydrogels, scaffold microneedles, improve use healing regeneration.
Language: Английский
Citations
60
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(10), P. 4375 - 4397
Published: July 11, 2023
Abstract Cancer is the most common cause of death worldwide, following cardiovascular diseases. a multifactorial disease and many reasons such as physical, chemical, biological, lifestyle‐related factors. Nutrition, which one various factors that play role in prevention, development, treatment types cancer, affects immune system, characterized by disproportionate pro‐inflammatory signaling cancer. Studies investigating molecular mechanisms this effect have shown foods rich bioactive compounds, green tea, olive oil, turmeric, soybean significant positively changing expression miRNAs involved regulation genes associated with oncogenic/tumor‐suppressing pathways. In addition to these foods, some diet models may change specific cancer‐related different ways. While Mediterranean has been anticancer effects, high‐fat diet, methyl‐restricted are considered negative effects. This review aims discuss effects called “immune foods,” models, components on cancer prevention
Language: Английский
Citations
58
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Aug. 31, 2023
Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof concept, we isolated and identified Portulaca oleracea L-derived (PELNs) from edible L, which exhibited desirable nano-size (~ 160 nm) negative zeta potential value (-31.4 mV). Oral administration PELNs effectively suppressed expressions pro-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-1β) myeloperoxidase (MPO), increased levels anti-inflammatory cytokine (IL-10), alleviated acute dextran sulfate sodium (DSS)-induced C57 mice IL-10-/- mice. Notably, excellent stability safety within gastrointestinal tract displayed specific targeting to inflamed sites colons Mechanistically, oral played crucial role maintaining diversity balance gut microbiota. Furthermore, enhanced Lactobacillus reuteri growth elevated indole derivative levels, might activate aryl-hydrocarbon receptor (AhR) conventional CD4+ T cells. This activation downregulated Zbtb7b expression, leading reprogramming cells into double-positive CD4+CD8+T (DP CD4+CD8+ cells). In conclusion, our findings highlighted orally administered as novel, natural, colon-targeted agent, offering promising therapeutic approach for managing UC. Schematic illustration effects L -derived natural on downregulate expression Zbtb7b, reprogram cells), decrease cytokines.
Language: Английский
Citations
57
Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 839 - 839
Published: May 15, 2023
Plant cells release tiny membranous vesicles called extracellular (EVs), which are rich in lipids, proteins, nucleic acids, and pharmacologically active compounds. These plant-derived EVs (PDEVs) safe easily extractable have been shown to therapeutic effects against inflammation, cancer, bacteria, aging. They promise preventing or treating colitis, alcoholic liver disease, even COVID-19. PDEVs can also be used as natural carriers for small-molecule drugs acids through various administration routes such oral, transdermal, injection. The unique advantages of make them highly competitive clinical applications preventive healthcare products the future. This review covers latest methods isolating characterizing PDEVs, their disease prevention treatment, potential a new drug carrier, with special attention commercial viability toxicological profile, future nanomedicine therapeutics. champions formation task force specializing address global need rigor standardization PDEV research.
Language: Английский
Citations
55