Treatment of colorectal cancer by anticancer and antibacterial effects of hemiprotonic phenanthroline-phenanthroline+ with nanomicelle delivery DOI Creative Commons
Yingying Zhang, Zizhen Zhao, Jingli Li

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100801 - 100801

Published: March 28, 2023

Colorectal cancer (CRC) is a common digestive tract tumor worldwide. Specific microorganisms, including Fusobacterium nucleatum (F. nucleatum) and Escherichia coli (E. coli), are abundant in colonic mucosa can promote the progression malignancy. Therefore, therapeutic strategy proposed to deliver effective drugs colorectum for both anticancer antibacteria. Here we used thin-film dispersion method encapsulate hemiprotonic phenanthroline-phenanthroline+ (ph-ph+) into nanomicelle. The results showed that drug-loading nanomicelle had good dispersion, particle size was about 28 nm. In vitro assay indicated active against CRC-related obligate facultative anaerobes. human CRC cells, could effectively inhibit cell proliferation induce apoptosis. vivo distribution release ph-ph+ mainly colorectum. model mice, significantly reduced number volume, decreased bacteria load colorectal inflammation. Together, study identifies ph-ph+nanomicelle has potential apply treating CRC, also suggests combined with antimicrobial therapy would be feasible way therapy.

Language: Английский

Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: novel insights and perspectives DOI Creative Commons
Haiying Wang, Qiao Chu,

Qiutong Guan

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(4), P. 100829 - 100829

Published: July 1, 2023

Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.

Language: Английский

Citations

37
Esculin induces endoplasmic reticulum stress and drives apoptosis and ferroptosis in colorectal cancer via PERK regulating eIF2α/CHOP and Nrf2/HO-1 cascades DOI Creative Commons

Xiaoke Ji,

Zongpin Chen,

Weifan Lin

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118139 - 118139

Published: March 30, 2024

Language: Английский

Citations

14
Multifunctional iron-apigenin nanocomplex conducting photothermal therapy and triggering augmented immune response for triple negative breast cancer DOI
Ruijie Chen, Zewei Jiang,

Yingfeng Cheng

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 124016 - 124016

Published: March 19, 2024

Language: Английский

Citations

12
Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy DOI Creative Commons

Afsana Sheikh,

Prashant Kesharwani, Waleed Hassan Almalki

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 2, 2024

As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.

Language: Английский

Citations

9
Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma DOI Creative Commons
Piao Luo, Qian Zhang, Shuo Shen

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(6), P. 100874 - 100874

Published: Nov. 1, 2023

Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the Tripterygium wilfordii plant, has been extensively researched for its potential effectiveness in fighting cancer. However, clinical application hindered by unclear mechanism action. Here, we used chemical proteomics to identify direct targets Cel enhanced targetability anti-tumor capacity developing Cel-based liposomes HCC. We demonstrated that selectively voltage-dependent anion channel 2 (VDAC2). directly binds cysteine residues VDAC2, induces cytochrome C release via dysregulating VDAC2-mediated mitochondrial permeability transition pore (mPTP) function. further found ROS-mediated ferroptosis apoptosis HCC cells. Moreover, coencapsulation into alkyl glucoside-modified (AGCL) improved antitumor efficacy minimized side effects. AGCL shown effectively suppress proliferation tumor In xenograft nude mice experiment, significantly inhibited growth promoted apoptosis. Our findings reveal VDAC2 induce mitochondria-dependent cell death, while enhance reduces Overall, shows promise as therapeutic agent

Language: Английский

Citations

19
Recent advancements in nanomaterial-mediated ferroptosis-induced cancer therapy: Importance of molecular dynamics and novel strategies DOI Creative Commons
Namdev Dhas, Ritu Kudarha, Ruchı Tıwarı

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122629 - 122629

Published: April 15, 2024

Ferroptosis is a novel type of controlled cell death resulting from an imbalance between oxidative harm and protective mechanisms, demonstrating significant potential in combating cancer. It differs other forms death, such as apoptosis necrosis. Molecular therapeutics have hard time playing the long-acting role ferroptosis induction due to their limited water solubility, low targeting capacity, quick metabolism vivo. To this end, small molecule inducers based on biological factors long been used strategy induce death. Research into advancements nanotechnology led discovery that nanomaterials are superior medications triggering ferroptosis. Nanomaterials derived iron can enhance by directly releasing large quantities increasing ROS levels. Moreover, utilizing promote programmed minimizes probability unfavorable effects induced mutations cancer-associated genes RAS TP53. Taken together, review summarizes molecular mechanisms involved along with classification induction. also emphasized importance organelles control cancer therapy. The trigger categorized explained. Iron-based noniron-based characterization at cellular levels explored, which will be useful for inducing leads reduced tumor growth. Within framework, we offer synopsis, traverses well-established mechanism offers practical suggestions design therapeutic use nanomaterials.

Language: Английский

Citations

7
Harnessing Ferroptosis to Overcome Drug Resistance in Colorectal Cancer: Promising Therapeutic Approaches DOI Open Access
Xiaofei Cheng, Feng Zhao, Bingxin Ke

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(21), P. 5209 - 5209

Published: Oct. 30, 2023

Drug resistance remains a significant challenge in the treatment of colorectal cancer (CRC). In recent years, emerging field ferroptosis, unique form regulated cell death characterized by iron-dependent lipid peroxidation, has offered new insights and potential therapeutic strategies for overcoming drug CRC. This review examines role ferroptosis CRC its impact on resistance. It highlights distinctive features advantages compared to other pathways, such as apoptosis necrosis. Furthermore, discusses current research advances field, including novel approaches that target ferroptosis. These involve use inducers, interventions iron metabolism combination therapies enhance efficacy The also explores immunotherapy modulating strategy. Additionally, it evaluates strengths limitations targeting selectivity, low side effects, overcome resistance, well challenges related specificity development. Looking future, this prospects ferroptosis-based CRC, emphasizing importance further elucidate interaction between proposes future directions more effective strategies, development approaches, therapies, integration with fields precision medicine. conclusion, harnessing represents promising avenue Continued efforts are crucial optimizing outcomes providing hope patients.

Language: Английский

Citations

16
Ultrafast self-assembled supramolecular nanoparticles for enhanced chemodynamic therapy and ferroptosis through lactic acid metabolism regulation DOI Open Access
Qi Meng, Jia Tan,

Weifang Tong

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 471, P. 144563 - 144563

Published: July 3, 2023

Language: Английский

Citations

15
Ferroptosis-based drug delivery system as a new therapeutic opportunity for brain tumors DOI Creative Commons
Yansheng Yao, Peng Ji, Hao Chen

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 23, 2023

The brain tumor is a kind of malignant with brutal treatment, high recurrence rate, and poor prognosis, the incidence death rate increasing yearly. Surgery often used to remove primary tumor, supplemented by radiotherapy chemotherapy, which have highly toxic side effects. Therefore, there an urgent need explore new strategies, methods, technologies that can genuinely improve treatment tumors. Ferroptosis differs from traditional apoptosis’s morphological biochemical characteristics, ferroptosis possesses its unique characteristics mechanisms, opening up field for cancer. It has been found close relationship between tumors, novel nano-drug delivery system based on tumors remarkable This review firstly analyzes ferroptosis, summarizes mechanism occurrence some factors be involved in regulation introduces potential link clarifies feasibility then presents nano drug systems developed under different metabolic pathways Finally, it current problems solutions drugs aiming provide reference developing against

Language: Английский

Citations

13
A promising new approach to cancer therapy: Manipulate ferroptosis by hijacking endogenous iron DOI
Luwen Zhu, Yong‐Zhong Du

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124517 - 124517

Published: July 29, 2024

Language: Английский

Citations

5