JMIR Human Factors, Journal Year: 2024, Volume and Issue: 11, P. e54172 - e54172
Published: April 17, 2024
Sjögren's syndrome (SS) is the second most common autoimmune rheumatic disease, and range of symptoms includes fatigue, dryness, sleep disturbances, pain. Smartphone apps may help deliver a variety cognitive behavioral techniques to support self-management in SS. However, app-based interventions must be carefully designed promote engagement motivate behavior change.
Language: Английский
The Lancet, Journal Year: 2023, Volume and Issue: 402(10397), P. 235 - 249
Published: June 23, 2023
Language: Английский
Citations
43
Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 153, P. 106117 - 106117
Published: April 19, 2023
Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework but been hampered lack consistent definition.
Language: Английский
Citations
29
JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(5), P. e2313989 - e2313989
Published: May 18, 2023
Elevated allostatic load (AL) has been associated with adverse socioenvironmental stressors and tumor characteristics that convey poor prognosis in patients breast cancer. Currently, the association between AL all-cause mortality cancer is unknown.To examine cancer.This cohort study used data from an institutional electronic medical record registry at National Cancer Institute Comprehensive Center. Participants were diagnoses (stage I-III) January 1, 2012, through December 31, 2020. Data analyzed April 2022 November 2022.AL was expressed as a summary score calculated by assigning 1 point for biomarkers worst sample quartile. High defined greater than median.The main outcome mortality. A Cox proportional hazard models robust variance tested mortality.There 4459 (median [IQR] age, 59 [49-67] years) ethnoracial distribution of 3 Hispanic Black (0.1%), 381 non-Hispanic (8.5%), 23 White (0.5%), 3861 (86.6%), 27 other race (0.6%), 164 (3.7%). The mean (SD) 2.6 (1.7). (adjusted relative ratio [aRR], those 1.11; 95% CI, 1.04-1.18), single marital status (aRR, 1.06; 1.00-1.12), government-supplied insured (Medicaid aRR, 1.14; 1.07-1.21; Medicare 1.03-1.19) had higher adjusted who White, married/living married, or privately insured, respectively. Adjusting sociodemographic, clinical, treatment factors, high 46% increase risk (hazard [HR], 1.46; 1.11-1.93) over low AL. Similarly, compared first quartile, third quartile (HR, 1.53; 1.07-2.18) fourth 1.79; 1.16-2.75) significantly increased risks There significant dose-dependent Furthermore, remained after adjusting Charlson Comorbidity Index.These findings suggest reflective socioeconomic marginalization
Language: Английский
Citations
29
Cancer Epidemiology Biomarkers & Prevention, Journal Year: 2024, Volume and Issue: 33(7), P. 870 - 873
Published: May 15, 2024
Advances in cancer prevention, early detection, and treatments have led to unprecedented progress against cancer. However, these advances not benefited everyone equally. Because of a long history structural inequities systemic injustices the United States, many segments US population continue shoulder disproportionate burden The American Association for Cancer Research (AACR) Disparities Progress Report 2024 (CancerDisparitiesProgressReport.org) outlines recent disparities, ongoing challenges faced by medically underserved populations, emphasizes vital need further research patient care benefit all populations.
Language: Английский
Citations
11
Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2267 - 2267
Published: Aug. 14, 2023
Physical activity has been demonstrated to have a significant impact on gut microbial diversity and function. Emerging research revealed certain aspects of the complex interactions between gut, exercise, microbiota, neurodegenerative diseases, suggesting that changes in metabolic function may an onset progression neurological conditions. This study aimed review current literature from several databases until 1 June 2023 (PubMed/MEDLINE, Web Science, Google Scholar) interplay physical neurodegeneration. We summarized roles exercise microbiota neurodegeneration identified ways which these are all connected. The gut–brain axis is multifaceted network gained considerable attention recent years. Research indicates plays vital shifts during physiological or pathophysiological conditions diseases; therefore, they closely related maintaining overall health well-being. Similarly, shown positive effects brain cognitive function, reduce/delay severe disorders. Exercise associated with various neurochemical changes, including alterations cortisol levels, increased production endorphins, endocannabinoids like anandamide, as well higher levels serotonin dopamine. These linked mood improvements, enhanced sleep quality, better motor control, enhancements resulting exercise-induced effects. However, further clinical necessary evaluate bacteria taxa along age- sex-based differences.
Language: Английский
Citations
21
Journal of Health and Social Behavior, Journal Year: 2024, Volume and Issue: 65(4), P. 558 - 576
Published: March 16, 2024
Observing an association between socioeconomic status (SES) and health reliably leads to the question, "What are pathways involved?" Despite enormous investment in research on characteristics, behaviors, traits of people disadvantaged with respect inequalities, issue remains unresolved. We turn our attention actions more advantaged groups by asking self-report their exposure disrespect, discrimination, exclusion, shaming (DDES) from above them SES hierarchy. developed measures these phenomena administered a cross-sectional U.S. national probability sample (N = 1,209). Consistent possibility that DDES represents pathway linking health, SES→health coefficient dropped substantially when variables were controlled: 112.9% for anxiety, 43.8% self-reported 49.4% cardiovascular-related conditions. These results illustrate need relational approach emphasizing shaping inequities.
Language: Английский
Citations
6
Circulation Research, Journal Year: 2024, Volume and Issue: 134(9), P. 1083 - 1097
Published: April 25, 2024
Poor air quality accounts for more than 9 million deaths a year globally according to recent estimates. A large portion of these are attributable cardiovascular causes, with evidence indicating that pollution may also play an important role in the genesis key cardiometabolic risk factors. Air is not experienced isolation but part complex system, influenced by host other external environmental exposures, and interacting intrinsic biologic factors susceptibility ultimately determine metabolic outcomes. Given same fossil fuel emission sources cause climate change result pollution, there need robust approaches can only limit eliminate health effects, emphasis protecting most susceptible targeting interventions at vulnerable populations. In this review, we summarize current state epidemiologic mechanistic underpinning association disease how interactions exposures individual characteristics modify associations. We identify gaps literature suggest emerging policy makers holistically approach impact assessment.
Language: Английский
Citations
6
International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(24), P. 17006 - 17006
Published: Dec. 18, 2022
Background: Neighborhoods are critical to understanding how environments influence health outcomes. Prolonged environmental stressors, such as a lack of green spaces and neighborhood socioeconomic disadvantage, have been associated with higher allostatic load levels. Since levels experienced earlier in life stronger associations mortality risk, neighborhoods may be uniquely suited monitor mitigate the impacts stressors. Researchers often study by utilizing administrative boundaries within publicly accessible databases proxies for neighborhoods. Methods: This systematic review reviews aims identify commonly used biomarkers measurement load, compare approaches, inventory spotlight considerations referenced literature where is studied The was conducted using search term “allostatic load” MEDLINE, CINAHL, PsychINFO databases. results were filtered include reviews. Results: returned 499 articles after deduplication. Overall, 18 synthesis met inclusion criteria retained extraction. analyzed represented 238 studies published from 1995 2020. original ten most measure load. More recently, body mass index C-reactive protein additionally frequently burden. Conclusions: scientific contributions this that we identified clear gap geographic when studying implication highlighted concepts conducting neighborhood-level research proxy outlined emerging future trends can enable context.
Language: Английский
Citations
27
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 148, P. 105145 - 105145
Published: March 29, 2023
Language: Английский
Citations
15
Breast Cancer Research, Journal Year: 2023, Volume and Issue: 25(1)
Published: Dec. 19, 2023
Allostatic load (AL) reflects the collective of chronic stress during lifetime. Previous studies have shown that higher AL is associated with poor clinical outcomes among breast cancer patients. However, relationship between and risk still unclear.
Language: Английский
Citations
13