SARS‐CoV‐2 infection and multi-organ system damage: a review

Bosnian Journal of Basic Medical Sciences, Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 16, 2022

The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred million people globally as of August 2022. Organs and cells harboring angiotensin-converting enzyme 2 (ACE2) surface receptors are the primary targets virus. However, once it enters body through respiratory system, virus can spread hematogenously to infect other organs. Therefore, COVID-19 affects many organs, causing severe long-term complications, even after disease ended, thus worsening quality life. Although is known that system most by infection, organs/systems in short long term. Since simultaneously redesigning diagnostic therapy policies fit damaged organs strongly recommended. Even though pathophysiology problems unknown, frequency cases rises with age existence preexisting symptoms. This study aims update our knowledge multi-organ dysfunction interaction based on clinical theoretical evidence. For this purpose, comprehensively elucidates recent studies effects multiple systems, including respiratory, cardiovascular, gastrointestinal, renal, nervous, endocrine, reproductive, immune, parts integumentary system. Understanding range atypical symptoms could improve surveillance, limit transmission, avoid additional multi-organ-system problems.

Language: Английский

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Rate of vertical transmission of coronavirus disease 2019 and effect of maternal vaccination: A prospective cohort study

Pediatrics International, Journal Year: 2025, Volume and Issue: 67(1)

Published: Jan. 1, 2025

Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers at delivery), postinfection recovered from during pregnancy), vaccinated pregnancy). Specimen collections, polymerase chain reaction assays, anti‐SARS‐CoV‐2 antibody measurements, examinations conducted for 6 months delivery. Results Sixty‐nine mothers 70 enrolled. SARS‐CoV‐2 was detected in placenta 22% 21% group. Neither nor SARS‐CoV‐2‐specific IgM infants. No anomalies, functional disorders, or developmental problems observed months. Compared group, there significant increase titers according number vaccinations, which maintained longer than first month life. Conclusions Vertical not despite protocol. more often placenta, appeared prevent vertical transmission. Maternal increased considered immunologically efficient. Vaccination pregnancy is important preventing congenital, neonatal, infantile COVID‐19.

Language: Английский

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Neonatal outcomes and indirect consequences following maternal SARS-CoV-2 infection in pregnancy: a systematic review

BMJ Open, Journal Year: 2023, Volume and Issue: 13(3), P. e063052 - e063052

Published: March 1, 2023

Objectives To identify the association between maternal SARS-CoV-2 infection in pregnancy and individual neonatal morbidities outcomes, particularly longer-term outcomes such as neurodevelopment. Design Systematic review of neonates born to pregnant women diagnosed with a at any stage during pregnancy, including asymptomatic women. Data sources MEDLINE, Embase, Global Health, WHOLIS LILACS databases, last searched on 28 July 2021. Eligibility criteria Case–control cohort studies published after 1 January 2020, preprint articles were included. Study included mortality morbidity, preterm birth, caesarean delivery, small for gestational age, admission intensive care unit, level respiratory support required, diagnosis culture-positive sepsis, evidence brain injury, necrotising enterocolitis, visual or hearing impairment, neurodevelopmental feeding method. These selected according core outcome set. extraction synthesis extracted into Microsoft Excel by two researchers, statistical analysis completed using IBM SPSS (Version 27). Risk bias was assessed modified Newcastle-Ottawa Scale. Results The search returned 3234 papers, from which 204 total 45 646 infants mothers across 36 countries. We found limited an increased risk some morbidities, disease. There minimal low-income settings (1 study) following first trimester (17 studies). Neonatal very rare. Preterm unit age status more common most larger studies. Conclusions are data morbidity infection, countries early infections. Large, representative addressing these needed understand consequences babies SARS-CoV-2. PROSPERO registration number CRD42021249818.

Language: Английский

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The silent reservoir? SARS-CoV-2 detection in the middle ear effusion of patients with Otitis media with effusion after omicron infection

American Journal of Otolaryngology, Journal Year: 2024, Volume and Issue: 45(3), P. 104229 - 104229

Published: Feb. 23, 2024

Language: Английский

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Evaluation of hearing screening results of newborns born to SARS-CoV-2 positive pregnant women

Northwestern Medical Journal, Journal Year: 2025, Volume and Issue: 5(1), P. 46 - 50

Published: Jan. 31, 2025

Aim: It is a scientific fact that certain viral infections during pregnancy cause hearing loss in newborns. The aim of this study was to investigate whether such are the congenital loss. This based on an examination screening newborns born pregnant women affected by current pandemic caused SARS-CoV-2 virus, which responsible for disease designated Coronavirus Disease 2019 (COVID-19). Materials and Methods: In retrospective case-control study, demographic data ABR test results total 81 were compared with those 101 healthy controls. mothers who tested positive polymerase chain reaction (PCR) between March September 2022. controls had no problems pregnancy. Results: prevalence PCR positivity 3.5%. A higher cesarean delivery rate observed group infection (p=0.028). failure initial both groups (22/81 vs. 25/101; p=0.712). However, subsequent analysis revealed there statistically significant difference secondary follow-up (p=0.926). Conclusion: suggest indication maternal neonatal

Language: Английский

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Updates on Auditory Outcomes of COVID-19 and Vaccine Side Effects: An Umbrella Review

Journal of Speech Language and Hearing Research, Journal Year: 2025, Volume and Issue: 68(3), P. 1311 - 1332

Published: Feb. 21, 2025

This umbrella review synthesizes and discusses systematic reviews (SRs) meta-analyses (MAs) on auditory outcomes associated with COVID-19 infection vaccination side effects. It is innovative in offering a comprehensive synthesis of evidence across adults infants while summarizing vaccine-related literature search followed the Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines, no restrictions population age or symptom severity. Four electronic databases were searched from their inception to October 2024. The Assessment Multiple 2 checklist Risk Bias tool used assess quality risk bias. identified 534 articles, narrowed down 14 SRs following full-text review: Nine focused COVID-19; two, born mothers infected during pregnancy; three, effects vaccination. A random-effects model revealed significantly high pooled estimates hearing loss (5.0%, 95% CI [1.0, 9.0], p < .012, three MAs, N = 21,932) tinnitus (13.5%, [5.9, 21.1], ≤ .001, four 36,236) adults. However, current nonhospitalized patients indicates that symptoms often improve after recovery. Studies also show low rate whose contracted pregnancy. Similarly, whereas has been linked tinnitus, these are rare, most experience improvement within weeks months. Evidence suggests adults, although remain rare newborns caution warranted due limitations variability studies.

Language: Английский

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Prenatal Maternal COVID-19 and Offspring Risk for Morbidities Up to the Age of One Year

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Background: Prenatal maternal coronavirus disease 2019 (COVID-19) infection may worsen the clinical course of and increase risk for adverse obstetric neonatal outcomes depending on severity timing exposure. Data regarding long-term impact offspring exposed to prenatal COVID-19 are still limited. Objective: To study association between infectious diseases, respiratory complications, developmental delay up age 1 year. Study design: A retrospective cohort was conducted. The included 19,050 women-offspring dyads who delivered at Soroka University Medical Center December 30, 2020, July 2022, them, 2663 (14%) women were diagnosed with during pregnancy. Pregnancy, delivery complications compared pregnancy not. Multivariable logistic regression models performed examine selected diagnoses, while adjusting background characteristics, among offspring, compare incidence diagnoses based trimester infection. Results: Offspring mothers infections higher viral [adjusted odds ratio (OR) = 1.167; 95% CI 1.028–1.325, P 0.017], specifically third trimester. lower in cases where second These increased COVID-19; however, only if infected earlier No associations observed (0.8% vs. 1.1%, OR 0.724, 0.46–1.14, 0.161) or (3.3% 4%, 0.83, 0.662–1.041, 0.107). Conclusions: year old, late gestation including first life.

Language: Английский

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Monitoring of Auditory Function in Newborns of Women Infected by SARS-CoV-2 during Pregnancy

Children, Journal Year: 2023, Volume and Issue: 10(2), P. 194 - 194

Published: Jan. 20, 2023

Gestational SARS-CoV-2 infection can impact maternal and neonatal health. The virus has also been reported to cause newborn sensorineural hearing loss, but its consequences for the auditory system are not fully understood.The aim of this study was evaluate during pregnancy on newborn' function first year life.An observational conducted from 1 November 2020 30 2021 at University Modena Hospital. All newborns whose mother had infected by were enrolled underwent audiological evaluation birth age.A total 119 neonates born mothers pregnancy. At birth, five (4.2%) presented an increased threshold ABR (Auditory Brainstem Evoked Response), results confirmed only in 1.6% cases, when repeated month later, while thresholds all other children returned normal limits. 1-year follow-up, no cases moderate or severe loss observed, concomitant disorders middle ear frequently observed.Maternal infection, regardless trimester which it contracted, appears induce infants. It is important clarify possible effect late-onset future research needed.

Language: Английский

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Effect of COVID-19 on Pregnancy and Neonate’s Vital Parameters: A Systematic Review

Journal of Pregnancy, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 21

Published: May 13, 2023

Background. COVID-19 is a new pandemic, which was declared by the World Health Organization in 2019 as threat to public health. According numerous reports, it can have negative consequences for pregnant women, labour, and neonates born infected mothers. The aim of this paper gather evidence present summary results studies concerning women their neonates. Methods. Articles from prestigious journals covering period 2020 February 2023, relevant review papers, original research articles PubMed were analysed. In order analyse available literature, Web Science, Scopus, databases used, search conducted using terms (“pregnancy,” “coronavirus,” “SARS-CoV-2,” “newborn”) PRISMA (Preferred Reporting Items Systemic Reviews Meta-Analysis) guidelines clinical trials. Meta-analyses systematic reviews (2022–2023) on symptoms, neonatal course, risk infection been summarized. Summary meta-analyses effect adverse reaction vaccination presented. Results. As result conducted, confirmed that most no serious signs observed, although isolated cases death related reported. Several authors called attention more severe course with obesity. It seemed vertical transmission mother child occurring. Nevertheless, information not clinching. condition mothers described normal; however, some papers reported deaths Conclusions. Due insufficient data, further necessary. Further follow-up are recommended, would make possible an assessment remote effects pregnancy vital parameters newborn.

Language: Английский

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Hearing screening test in neonates born to COVID-19–positive mothers

European Journal of Pediatrics, Journal Year: 2022, Volume and Issue: 182(3), P. 1077 - 1081

Published: Dec. 24, 2022

Language: Английский

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