A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects DOI Creative Commons
Samreen Sadiq, Shoaib Khan, Iltaf Khan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25521 - e25521

Published: Feb. 1, 2024

Nanomaterials (NMs) have garnered significant attention in recent decades due to their versatile applications a wide range of fields. Thanks tiny size, enhanced surface modifications, impressive volume-to-surface area ratio, magnetic properties, and customized optical dispersion. NMs experienced an incredible upsurge biomedical including diagnostics, therapeutics, drug delivery. This minireview will focus on notable examples that tackle important issues, demonstrating various aspects such as design, synthesis, morphology, classification, use cutting-edge applications. Furthermore, we classified outlined the distinctive characteristics advanced nanoscale particles hybrid NMs. Meanwhile, emphasize potential metal-organic frameworks (MOFs), highly group These MOFs gained recognition promising candidates for bio-applications, bioimaging, biosensing, antiviral therapy, anticancer nanomedicines, theranostics, immunotherapy, photodynamic photothermal gene Although shown great field, clinical is still limited by issues stability, cytotoxicity, biocompatibility, health concerns. review article provides thorough analysis offering valuable insights researchers investigating explore new development, expansion opportunities. Remarkably, ponder prospects nanocomposites conjunction with current technology.

Language: Английский

Nanoscale MOFs: From synthesis to drug delivery and theranostics applications DOI

Mengli Ding,

Wenbo Liu, Ruxandra Gref

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114496 - 114496

Published: Aug. 12, 2022

Language: Английский

Citations

194
Applications of Metal-Organic Frameworks as Drug Delivery Systems DOI Open Access
Bianca Maranescu, Aurelia Visa

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4458 - 4458

Published: April 18, 2022

In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of compounds. The DSSs allow release active pharmaceutical ingredient accomplish desired therapeutic response. Over past few decades, there has been exponential growth many classes coordination polymers, MOFs gained popularity over other identified higher biocompatibility versatile loading capabilities. This review presents assesses most recent research, findings, challenges associated with use DDSs. Among commonly used for investigated-purpose MOFs, polymers complexes based on synthetic natural are well known. Specific attention is given stimuli- multistimuli-responsive MOFs-based Of interest in COVID-19 pandemic combination therapy multimodal systems.

Language: Английский

Citations

143
Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review DOI Creative Commons

Miral Al Sharabati,

Rana Sabouni, Ghaleb A. Husseini

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(2), P. 277 - 277

Published: Jan. 16, 2022

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, science, and chemistry applications. Recently, these structures been thoroughly studied as promising platforms for biomedical Due to their unique physical properties, they regarded candidates disease diagnosis drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range pore shapes, ultrahigh surface area, relatively low toxicity, easy functionalization made them focus extensive research. This review highlights up-to-date progress potential delivery diseases such cancer, diabetes, neurological disorders, ocular diseases. A brief description synthesis methods is first presented. Various examples MOF-based sensors DDSs introduced different Finally, challenges perspectives discussed provide context future development efficient systems.

Language: Английский

Citations

136
Metal organic frameworks for antibacterial applications DOI
Li Yan, Ashna Gopal,

Saima Kashif

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134975 - 134975

Published: Feb. 2, 2022

Language: Английский

Citations

120
Recent advances in metal-organic frameworks: Synthesis, application and toxicity DOI
Qian Zhang,

Shuguang Yan,

Xueting Yan

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 902, P. 165944 - 165944

Published: Aug. 4, 2023

Language: Английский

Citations

114
Heterogeneous MIL-88A on MIL-88B hybrid: A promising eco-friendly hybrid from green synthesis to dual application (Adsorption and photocatalysis) in tetracycline and dyes removal DOI

Bahareh Rabeie,

Niyaz Mohammad Mahmoodi

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 654, P. 495 - 522

Published: Oct. 14, 2023

Language: Английский

Citations

104
Mutual Self-Regulation of d-Electrons of Single Atoms and Adjacent Nanoparticles for Bifunctional Oxygen Electrocatalysis and Rechargeable Zinc-Air Batteries DOI Creative Commons
Sundaram Chandrasekaran, Rong Hu, Lei Yao

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 11, 2023

Rechargeable zinc-air batteries (ZABs) are a promising energy conversion device, which rely critically on electrocatalysts to accelerate their rate-determining reactions such as oxygen reduction (ORR) and evolution (OER). Herein, we fabricate range of bifunctional M-N-C (metal-nitrogen-carbon) catalysts containing M-Nx coordination sites M/MxC nanoparticles (M = Co, Fe, Cu) using new class γ-cyclodextrin (CD) based metal-organic framework the precursor. With two types active interacting with each other in catalysts, obtained Fe@C-FeNC Co@C-CoNC display superior alkaline ORR activity terms low half-wave (E1/2) potential (~ 0.917 0.906 V, respectively), higher than Cu@C-CuNC 0.829 V) commercial Pt/C 0.861 V). As electrocatalyst, exhibits best performance, showing ORR/OER overpotential (ΔE) ~ 0.732 is much lower that 0.831 1.411 V), well most robust reported date. Synchrotron X-ray absorption spectroscopy density functional theory simulations reveal strong electronic correlation between metallic Co atomic Co-N4 catalyst can increase d-electron near Fermi level thus effectively optimize adsorption/desorption intermediates ORR/OER, resulting an enhanced electrocatalytic performance. The Co@C-CoNC-based rechargeable ZAB exhibited maximum power 162.80 mW cm-2 at 270.30 mA cm-2, combination + RuO2 158.90 265.80 cm-2) catalysts. During galvanostatic discharge 10 delivered almost stable voltage 1.2 V for 140 h, signifying virtue excellent activity.

Language: Английский

Citations

102
Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs DOI Creative Commons
Lakshmi Kumari,

Yash Choudhari,

Preeti Patel

et al.

Life, Journal Year: 2023, Volume and Issue: 13(5), P. 1099 - 1099

Published: April 27, 2023

A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it currently major hurdle bringing new drug molecules market. According some estimates, up 40% of commercialized products 70–90% candidates development stage are poorly soluble, which results low bioavailability, diminished therapeutic effects, dosage escalation. Because this, must be taken into consideration when developing fabricating pharmaceutical products. To date, number approaches have been investigated address problem poor solubility. This review article attempts summarize several conventional methods utilized increase soluble drugs. These include principles physical chemical such particle size reduction, solid dispersion, supercritical fluid technology, cryogenic inclusion complex formation techniques, floating granules. It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use co-solvents, hydrotrophy, polymorphs, amorphous dispersions, pH variation). Various nanotechnological liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, so forth also widely for enhancement. All these brought forward enhancement bioavailability orally administered drugs by improving water-soluble However, issues not completely resolved, owing challenges associated with current approaches, reproducibility large scale production. Considering that there no universal approach solving issues, more research needed simplify existing technologies, could commercially available employing techniques.

Language: Английский

Citations

82
Current research trends of nanomedicines DOI Creative Commons
Qiuyue Liu, Jiahui Zou, Zhongjian Chen

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4391 - 4416

Published: May 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Language: Английский

Citations

82
Current and promising applications of Hf(iv)-based MOFs in clinical cancer therapy DOI

Xuelin Chen,

Minmin Li,

Mingzi Lin

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(25), P. 5693 - 5714

Published: Jan. 1, 2023

Cancer is one of the greatest challenges in medical science today as it poses a serious threat to human life. In view this, myriad therapeutic strategies are being developed for treatment cancer. Despite use various approaches, they still insufficient The rapid advancement nanotechnology currently offers exciting possibilities creation novel cancer therapy approaches. Metal organic frameworks (MOFs) emerging multifunctional nanomaterials that find prospective applications biomedical field owing their porosity, large specific surface area, and diversified structures. Amongst varied categories MOFs, Hf(IV)-based MOFs have been since 2012 finding new hence this class gaining immense attention amongst material biomaterial chemists. Most importantly, Hf(IV)-MOFs comprising high Z-Hf metal content may be capable offering options therapy, nonlinear optics, fluorescent sensors, photoresponsive devices. review, progress using radiotherapy, chemotherapy, immunotherapy, phototherapeutic techniques, or combination two more these techniques explored. This review also provides insight regarding current limitations future prospects therapy.

Language: Английский

Citations

79