Multifunctional nanoparticle-mediated combining therapy for human diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

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d -lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma

Science Advances, Journal Year: 2023, Volume and Issue: 9(29)

Published: July 19, 2023

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype demonstrates great potential for remodeling the immunosuppressive tumor microenvironment (TME) hepatocellular carcinoma (HCC). d-lactate (DL; a gut microbiome metabolite) acts as an endogenous immunomodulatory agent that enhances Kupffer cells clearance pathogens. In this study, DL transformation TAMs was confirmed, and mechanisms underlying such were mainly due modulation phosphatidylinositol 3-kinase/protein kinase B pathway. A poly(lactide-co-glycolide) nanoparticle (NP) used load DL, DL-loaded NP modified with HCC membrane macrophage-binding peptide (M2pep), forming nanoformulation (DL@NP-M-M2pep). DL@NP-M-M2pep transformed remodeled TME in mice, promoting efficacy anti-CD47 antibody long-term animal survival. These findings reveal TAM modulatory function provide combinatorial strategy immunotherapy.

Language: Английский

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Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 5, 2023

Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is confirmed to activate the host immune system prevent, control, and eliminate tumors. Recently, a range chemotherapeutic drugs have been repurposed ICD inducers applied for tumor immunotherapy. However, several hurdles widespread application remain, namely poor water solubility, short blood circulation, non-specific tissue distribution, severe toxicity. Recent advances in nanotechnology pharmaceutical formulation foster development nano drug delivery systems tackle aforementioned expedite safe, effective, specific delivery. This review will describe barriers chemical highlight recent nanoformulations these

Language: Английский

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Recent Advances in Nanoformulations for Quercetin Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1656 - 1656

Published: June 5, 2023

Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE's low solubility and extended first-pass metabolism limit oral administration. This review aims present potential of various nanoformulations in development QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used more efficient encapsulation, targeting, controlled release QUE. An overview primary nanosystem categories, formulation processes, characterization techniques are described. In particular, lipid-based nanocarriers, such as liposomes, nanostructured-lipid carries, solid-lipid nanoparticles, widely improve absorption increase antioxidant activity, ensure sustained release. Moreover, polymer-based nanocarriers exhibit unique properties improvement Absorption, Distribution, Metabolism, Excretion, Toxicology (ADME(T)) profile. Namely, micelles hydrogels composed natural or synthetic polymers have been applied formulations. Furthermore, cyclodextrin, niosomes, nanoemulsions proposed alternatives administration via different routes. comprehensive provides insight into role advanced

Language: Английский

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Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 94 - 114

Published: Aug. 7, 2023

Immunogenic cell death (ICD) is a unique mode of death, which can release immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens to trigger long-term protective antitumor immune responses. Thus, amplifying "eat me signal" during tumor ICD cascade critical for cancer immunotherapy. Some therapies (radiotherapy, photodynamic therapy (PDT), photothermal (PTT), etc.) inducers (chemotherapeutic agents, have enabled initiate and/or facilitate activate Recently, nanostructure-based drug delivery systems been synthesized inducing through combining treatment chemotherapeutic photosensitizers PDT, transformation agents PTT, radiosensitizers radiotherapy, etc., loaded at an appropriate dosage in the designated place time, contributing higher efficiency lower toxicity. Also, immunotherapeutic combination with produce synergetic effects, thus potentiating Overall, our review outlines emerging inducers, nanostructure loading diverse evoke chemoradiotherapy, PTT or agents. Moreover, we discuss prospects challenges harnessing induction-based immunotherapy, highlight significance multidisciplinary interprofessional collaboration promote optimal translation this strategy.

Language: Английский

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Polysaccharide-based nanocarriers for efficient transvascular drug delivery

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 167 - 187

Published: Jan. 9, 2023

Language: Английский

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Synergistic Osteogenic and Antiapoptotic Framework Nucleic Acid Complexes Prevent Diabetic Osteoporosis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(28)

Published: March 12, 2024

Abstract Diabetes mellitus (DM) is characterized by elevated blood glucose and advanced glycation end product (AGEs) levels. Increased AGEs in bone tissue inhibit osteogenic differentiation marrow mesenchymal stem cells (BMSCs), leading to loss osteoporosis diabetic patients. Enhancing the capacity of BMSCs presence abundant can improve health prevent DM The flavonoid, Quercetin, has anti‐inflammatory, antibacterial, antitumor properties; however, it insoluble water thus not easily absorbed body. Nanodrug delivery systems such as tetrahedral framework nucleic acids (tFNAs) exhibit excellent biocompatibility, efficient cell uptake, drug piggybacking. In present study, tFNAs with quercetin complexed form a novel nanodrug (tFNAs/Que) that combined features both components. tFNAs/Que promote an vitro AGEs‐rich environment, maintain mass, mice vivo. mechanism against may be related JNK signaling pathway. conclusion, shown dual regulatory role promoting inhibiting apoptosis. Such feature promising for prevention treatment osteoporosis.

Language: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

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Multifunctional Biomimetic Liposomes with Improved Tumor‐Targeting for TNBC Treatment by Combination of Chemotherapy, Anti‐Angiogenesis and Immunotherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 20, 2024

Triple negative breast cancer (TNBC) featuring high relapses and metastasis shows limited clinical therapeutic efficiency with chemotherapy for the extremely complex tumor microenvironment, especially angiogenesis immunosuppression. Combination of antiangiogenesis immunotherapy holds promise effective inhibition proliferation invasion, while it remains challenging specific targeting drug delivery to tumors metastatic lesions. Here, a multifunctional biomimetic liposome loading Gambogic acid (G/R-MLP) is developed using Ginsenoside Rg3 (Rg3) substitute cholesterol cell membrane coating, which designed increase long-circulating action by low immunogenicity specifically deliver gambogic (GA) site lesions homologous glucose transporter targeting. After G/R-MLP accumulates in primary nodules, synergistically enhances antitumor efficacy GA, effectively suppressing growth lung killing cells, inhibiting migration achieving improving immunity. All all, strategy combining chemotherapy, antiangiogenesis, improves prolonged survival, providing new perspective treatment TNBC.

Language: Английский

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Rare ginsenosides: A unique perspective of ginseng research

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 66, P. 303 - 328

Published: Jan. 7, 2024

Rare ginsenosides (Rg3, Rh2, C-K, etc.) refer to a group of dammarane triterpenoids that exist in low natural abundance, mostly produced by deglycosylation or side chain modification via physicochemical processing metabolic transformation gut, and last but not least, exhibited potent biological activity comparing the primary ginsenosides, which lead high concern both research development ginseng ginsenoside-related nutraceutical products. Nevertheless, comprehensive review on these promising compounds is available yet. Review In this review, recent advances (RGs) were summarized dealing with structurally diverse characteristics, traditional usage, drug discovery situation, clinical application, pharmacological effects underlying mechanisms, structure-activity relationship, toxicity, stereochemistry properties, production strategies. Key Scientific Concepts A total 144 RGs skeletons bioactivities isolated from Panax species. acted as ligands some specific receptors, such bile acid steroid hormone adenosine diphosphate (ADP) receptors. The showed including immunoregulatory adaptogen-like effect, anti-aging anti-tumor well their cardiovascular cerebrovascular system, central nervous obesity diabetes, interaction gut microbiota. Clinal trials indicated potential RGs, while quality data remains inadequate, no obvious was founded. properties induced at C (20) also addressed pharmacodynamics behaviors, together state-of-art analytical strategies for identification saponin stereoisomers. Finally, batch preparation targeted designated heating acid/ alkaline-assisted processes, enzymatic biotransformation biosynthesis discussed. Hopefully, present can provide more clues extensive understanding future in-depth originated worldwide recognized plants.

Language: Английский

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