International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 5931 - 5949
Published: June 1, 2024
Abstract:
The
self-assembling
aggregated
structures
of
natural
products
have
gained
significant
interest
due
to
their
simple
synthesis,
lack
carrier-related
toxicity,
and
excellent
biological
efficacy.
However,
the
mechanisms
assembly
ability
traverse
gastrointestinal
(GI)
barrier
remain
unclear.
This
review
summarizes
various
intermolecular
non-covalent
interactions
structures,
drawing
on
research
indexed
in
Web
Science
from
2010
2024.
Cheminformatics
analysis
self-assembly
behaviors
small
molecules
supramolecular
aggregates
reveals
assembly-favorable
conditions,
aiding
drug
formulation.
Additionally,
explores
properties
macromolecules
like
polysaccharides,
proteins,
exosomes,
highlighting
role
delivery.
Strategies
overcome
barriers
enhance
bioavailability
are
also
discussed.
work
underscores
potential
oral
delivery
offers
insights
for
designing
more
effective
systems.
Keywords:
products,
self-assembly,
supramolecules,
delivery,
Advances in Colloid and Interface Science,
Journal Year:
2023,
Volume and Issue:
322, P. 103035 - 103035
Published: Nov. 3, 2023
Surface-functionalized
nanostructures
are
at
the
forefront
of
biotechnology,
providing
new
opportunities
for
biosensors,
drug
delivery,
therapy,
and
bioimaging
applications.
The
modification
significantly
impacts
performance
success
various
applications
by
enabling
selective
precise
targeting.
This
review
elucidates
widely
practiced
surface
strategies,
including
click
chemistry,
cross-coupling,
silanization,
aldehyde
linkers,
active
ester
maleimide
epoxy
other
protein
DNA-based
methodologies.
We
also
delve
into
application-focused
landscape
nano-bio
interface,
emphasizing
four
key
domains:
therapeutics,
biosensing,
environmental
monitoring,
point-of-care
technologies,
highlighting
prominent
studies.
insights
presented
herein
pave
way
further
innovations
intersection
nanotechnology
a
useful
handbook
beginners
professionals.
draws
on
sources,
latest
research
articles
(2018-2023),
to
provide
comprehensive
overview
field.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2227 - 2227
Published: Aug. 29, 2023
Therapeutic
polysaccharide-based
coatings
have
recently
emerged
as
versatile
strategies
to
transform
a
conventional
medical
implant
into
drug
delivery
system.
However,
the
translation
of
these
clinic
systems
still
requires
deeper
understanding
their
degradation/release
profiles.
This
claim
is
supported
by
little
or
no
data.
In
this
review
paper,
comprehensive
description
benefits
and
challenges
generated
provided.
Moreover,
latest
advances
made
towards
application
most
important
representative
based
on
polysaccharide
types
for
are
debated.
Furthermore,
suggestions/recommendations
future
research
speed
up
transition
from
laboratory
testing
clinical
applications
given.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3834 - 3854
Published: June 3, 2024
Immunotherapy
is
an
important
cancer
treatment
method
that
offers
hope
for
curing
patients.
While
immunotherapy
has
achieved
initial
success,
a
major
obstacle
to
its
widespread
adoption
the
inability
benefit
majority
of
The
success
or
failure
closely
linked
tumor's
immune
microenvironment.
Recently,
there
been
significant
attention
on
strategies
regulate
tumor
microenvironment
in
order
stimulate
anti-tumor
responses
immunotherapy.
distinctive
physical
properties
and
design
flexibility
nanomedicines
have
extensively
utilized
target
cells
(including
tumor-associated
macrophages
(TAMs),
T
cells,
myeloid-derived
suppressor
(MDSCs),
fibroblasts
(TAFs)),
offering
promising
advancements
In
this
article,
we
reviewed
aimed
at
targeting
various
focus
models
are
based
nanomedicines,
with
goal
inducing
enhancing
improve
It
worth
noting
combining
other
treatments,
such
as
chemotherapy,
radiotherapy,
photodynamic
therapy,
can
maximize
therapeutic
effects.
Finally,
identified
challenges
nanotechnology-mediated
needs
overcome
more
effective
nanosystems.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(24), P. 10084 - 10091
Published: June 5, 2024
Due
to
the
potential
off-tumor
signal
leakage
and
limited
biomarker
content,
there
is
an
urgent
need
for
stimulus-responsive
amplification-based
tumor
molecular
imaging
strategies.
Therefore,
two
tetrahedral
framework
DNA
(tFNA-Hs),
tFNA-H1AP,
tFNA-H2,
were
rationally
engineered
form
a
polymeric
tFNA
network,
termed
intelligent
in
AND-gated
manner.
The
network
was
designed
tumor-specific
by
leveraging
elevated
expression
of
apurinic/apyrimidinic
endonuclease
1
(APE1)
cytoplasm
instead
normal
cells
high
miRNA-21
cytoplasm.
activation
tFNA-H1AP
can
be
achieved
through
specific
recognition
cleavage
APE1,
targeting
site
(AP
site)
modified
within
stem
region
hairpin
(H1AP).
Subsequently,
facilitates
hybridization
activated
H1AP
on
with
2
(H2)
triggering
catalytic
assembly
(CHA)
reaction
that
opens
at
vertices
bind
H2
tFNA-H2
generate
fluorescence
signals.
Upon
completion
hybridization,
released,
initiating
subsequent
cycle
CHA
reaction.
achieve
vivo
also
enables
risk
stratification
neuroblastoma
patients.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
