Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 73, P. 101058 - 101058

Published: Jan. 19, 2024

Language: Английский

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tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 15, 2024

Abstract Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding (ncRNAs) produced by the specific cleavage precursor or mature tRNAs. tsRNAs involved in various basic biological processes such as epigenetic, transcriptional, post-transcriptional, and translation regulation, thereby affecting occurrence development human diseases, including cancers. Recent studies have shown that play an important role tumorigenesis regulating behaviors malignant proliferation, invasion metastasis, angiogenesis, immune response, tumor resistance, metabolism reprogramming. These may be potential targets for treatment. Furthermore, can exist abundantly stably bodily fluids (e.g., blood, serum, urine) form free encapsulated extracellular vesicles, intercellular communication microenvironment (TME). Meanwhile, their abnormal expression is closely related to clinicopathological features patients, staging, lymph node poor prognosis patients; thus, served novel liquid biopsy biomarker. This review summarizes discovery, production, analyzes molecular mechanisms applications therapy, which provide strategies early diagnosis targeted therapy tumors.

Language: Английский

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Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101004 - 101004

Published: Aug. 21, 2023

Language: Английский

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Towards understandings of serine/arginine-rich splicing factors

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(8), P. 3181 - 3207

Published: May 23, 2023

Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which regulate splice site recognition and spliceosome assembly during precursor messenger RNA splicing. SRSFs also participate in other metabolic events, such as transcription, translation nonsense-mediated decay, their shuttling between nucleus cytoplasm, making them indispensable for genome diversity cellular activity. Of note, aberrant SRSF expression and/or mutations elicit fallacies gene splicing, leading the generation of pathogenic protein isoforms, highlights therapeutic potential targeting treat diseases. In this review, we updated current understanding structures functions metabolism. Next, analyzed SRSF-induced outcomes cancers non-tumor The development some well-characterized inhibitors was discussed detail. We hope review will contribute future studies drug SRSFs.

Language: Английский

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Natural products reverse cancer multidrug resistance

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Cancer stands as a prominent global cause of death. One the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse MDR. Discovering novel potential modulators to reduce MDR by has become popular research area across globe. Numerous mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their modulatory activity. regulating signaling pathways or relevant expressed protein gene. Here we perform deep review previous achievements, advances in development treatment This aims provide some insights study products.

Language: Английский

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An insight into the dual role of MoS2-based nanocarriers in anticancer drug delivery and therapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 36 - 60

Published: March 27, 2024

Language: Английский

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A promising future of metal‐N‐heterocyclic carbene complexes in medicinal chemistry: The emerging bioorganometallic antitumor agents

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(5), P. 2194 - 2235

Published: April 9, 2024

Abstract Metal complexes based on N ‐heterocyclic carbene (NHC) ligands have emerged as promising broad‐spectrum antitumor agents in bioorganometallic medicinal chemistry. In recent decades, studies cytotoxic metal–NHC yielded numerous compounds exhibiting superior cytotoxicity compared to cisplatin. Although the molecular mechanisms of these anticancer are not fully understood, some potential targets and modes action been identified. However, a comprehensive review their biological is currently absent. general, apoptosis caused by metal–NHCs common tumor cells. They can cause series changes after entering cells, such mitochondrial membrane (MMP) variation, reactive oxygen species (ROS) generation, cytochrome c (cyt c) release, endoplasmic reticulum (ER) stress, lysosome damage, caspase activation, ultimately leading apoptosis. Therefore, detailed understanding influence cancer cell crucial. this review, we provide summary advances that trigger apoptotic death via different apoptosis‐related or signaling pathways, including B‐cell lymphoma 2 (Bcl‐2 family), p53, cyt c, ER thioredoxin reductase (TrxR) inhibition, so forth. We also discuss challenges, limitations, future directions elucidate emerging application

Language: Английский

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A hyaluronic acid modified copper-based metal-organic framework overcomes multidrug resistance via two-way redox dyshomeostasis under hypoxia

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140148 - 140148

Published: Jan. 1, 2025

Language: Английский

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Overcoming Cancer Drug Resistance with Nanoparticle Strategies for Key Protein Inhibition

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 3994 - 3994

Published: Aug. 23, 2024

Drug resistance remains a critical barrier in cancer therapy, diminishing the effectiveness of chemotherapeutic, targeted, and immunotherapeutic agents. Overexpression proteins such as B-cell lymphoma 2 (Bcl-2), inhibitor apoptosis (IAPs), protein kinase B (Akt), P-glycoprotein (P-gp) various cancers leads to by inhibiting apoptosis, enhancing cell survival, expelling drugs. Although several inhibitors targeting these have been developed, their clinical use is often hampered systemic toxicity, poor bioavailability, development. Nanoparticle-based drug delivery systems present promising solution improving solubility, stability, targeted delivery. These leverage Enhanced Permeation Retention (EPR) effect accumulate tumor tissues, reducing off-target toxicity increasing therapeutic efficacy. Co-encapsulation strategies involving anticancer drugs within nanoparticles shown potential achieving coordinated pharmacokinetic pharmacodynamic profiles. This review discusses mechanisms resistance, limitations current inhibitors, advantages nanoparticle overcoming challenges. By advancing technologies, we can enhance treatment outcomes move towards more effective therapies.

Language: Английский

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Tumor microenvironment diversity and plasticity in cancer multidrug resistance

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 188997 - 188997

Published: Oct. 12, 2023

Language: Английский

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