PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(6), P. e0304021 - e0304021
Published: June 14, 2024
Milk
thistle
seed
oil
is
still
not
a
well-known
edible
oil.
Silybum
marianum
(milk
thistle),
present
in
several
countries
and
the
only
known
representative
of
genus
.
However,
eburneum
,
which
an
endemic
plant
Spain,
Kenya,
Morocco,
Algeria,
Tunisia,
considered
marginalized
species.
The
work
first
report
that
gives
information
on
lipid
phenolic
profiles
Tunisian
S
compared
to
those
In
addition,
antioxidant
properties
these
oils
were
determined
with
DPPH,
FRAP,
KRL
assays,
their
ability
prevent
oxidative
stress
was
human
monocytic
THP-1
cells.
These
are
characterized
by
high
amounts
unsaturated
fatty
acids;
linoleic
acid
oleic
most
abundant.
Campesterol,
sitosterol,
stigmasterol,
β-amyrin
major
phytosterols
identified.
α-tocopherol
predominant
tocopherol
found.
also
contain
significant
compounds.
diversity
richness
acids,
compounds,
tocopherols
associated
activities
revealed
assays.
cells,
powerfully
reduced
induced
7-ketocholesterol
7β-hydroxycholesterol,
two
strongly
pro-oxidant
oxysterols
often
at
increased
levels
patients
age-related
diseases.
therefore
important
sources
bioactive
molecules
nutritional
interest
diseases,
frequency
increasing
all
due
length
life
expectancy.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(4), P. 3667 - 3683
Published: Jan. 17, 2023
The
brain
is
vulnerable
to
different
types
of
stresses,
particularly
oxidative
stress
as
a
result
oxygen
requirements/utilization
in
the
body.
Large
amounts
unsaturated
fatty
acids
present
increase
this
vulnerability.
Neurodegenerative
diseases
(NDDs)
are
disorders
that
characterized
by
gradual
loss
specific
neurons
and
attributed
broad
evidence
cell-level
stress.
accurate
characterization
neurological
relies
on
several
parameters
along
with
genetics
environmental
risk
factors,
making
therapies
less
efficient
fight
NDDs.
On
way
tackle
damage
discover
safe
therapies,
bioactives
at
edge
NDD
science.
Naturally
occurring
bioactive
compounds
such
polyphenols,
carotenoids,
essential
acids,
phytosterols,
oils,
etc.
interest
owing
their
potent
antioxidant
anti-inflammatory
activities,
they
offer
lots
brain-health-promoting
features.
This
Review
focuses
probing
neuroefficacy
bioefficacy
role
supporting
relatively
low
antioxidative
regenerative
capacities
brain,
neurogenesis,
neuroprotection,
ameliorating/treating
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
35, P. 495 - 516
Published: Feb. 21, 2024
During
skin
aging,
the
degeneration
of
epidermal
stem
cells
(EpiSCs)
leads
to
diminished
wound
healing
capabilities
and
disintegration.
This
study
tackles
this
issue
through
a
comprehensive
analysis
combining
transcriptomics
untargeted
metabolomics,
revealing
age-dependent
alterations
in
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(11)
Published: June 1, 2024
Abstract
Diabetic
kidney
disease
(DKD)
is
a
leading
cause
of
end
stage
renal
with
unmet
clinical
demands
for
treatment.
Lipids
are
essential
cell
survival;
however,
cells
have
limited
capability
to
metabolize
overloaded
lipids.
Dyslipidaemia
common
in
DKD
patients
and
ectopic
lipid
accumulation
associated
progression.
Unveiling
the
molecular
mechanism
involved
regulation
crucial
exploring
potential
therapeutic
targets.
In
this
review,
we
focused
on
underlying
cholesterol,
oxysterol
fatty
acid
metabolism
disorder
context
DKD.
Specific
regulators
different
compartment
TREM2
macrophages,
lipid‐related
macrophages
DKD,
were
discussed.
The
role
sodium‐glucose
transporter
2
inhibitors
improving
was
summarized.
Cells,
Journal Year:
2021,
Volume and Issue:
10(9), P. 2301 - 2301
Published: Sept. 3, 2021
Oxysterols
are
oxidized
derivatives
of
cholesterol
produced
by
enzymatic
activity
or
non-enzymatic
pathways
(auto-oxidation).
The
oxidation
processes
lead
to
the
synthesis
about
60
different
oxysterols.
Several
oxysterols
have
physiological,
pathophysiological,
and
pharmacological
activities.
effects
on
cell
death
processes,
especially
apoptosis,
autophagy,
necrosis,
oxiapoptophagy,
as
well
their
action
proliferation,
reviewed
here.
These
effects,
also
observed
in
several
cancer
lines,
could
potentially
be
useful
treatment.
differentiation
described.
Among
them,
properties
stimulating
osteogenic
mesenchymal
stem
cells
while
inhibiting
adipogenic
may
regenerative
medicine.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
The
study
explores
the
intricate
relationship
between
aging
and
development
of
noncommunicable
diseases
[NCDs],
focusing
on
whether
these
are
inevitable
consequences
or
primarily
driven
by
lifestyle
factors.
By
examining
epidemiological
data,
particularly
from
hunter-gatherer
societies,
highlights
that
many
NCDs
prevalent
in
modern
populations
rare
suggesting
a
significant
influence
choices.
It
delves
into
mechanisms
through
which
poor
diet,
smoking,
other
factors
contribute
to
systemic
physiological
imbalances,
characterized
oxidative
stress,
insulin
resistance
hyperinsulinemia,
dysregulation
sympathetic
nervous
system,
renin-angiotensin-aldosterone
immune
system.
interplay
this
pattern
individual
such
as
genetic
susceptibility,
biological
variability,
epigenetic
changes
microbiome
is
proposed
play
crucial
role
range
age-related
NCDs.
Modified
biomolecules
oxysterols
advanced
glycation
end
products
also
their
development.
Specific
benign
prostatic
hyperplasia,
Parkinson's
disease,
glaucoma
osteoarthritis
analyzed
illustrate
mechanisms.
concludes
while
contributes
risk
NCDs,
role,
offering
potential
avenues
for
prevention
intervention
healthier
living
practices.
One
possible
approach
could
be
try
restore
balance,
e.g.
dietary
measures
[e.g.
Mediterranean
Okinawan
diet
Paleolithic
diet]
conjunction
with
[a
combination
of]
pharmacological
interventions
changes.
Experimental Gerontology,
Journal Year:
2024,
Volume and Issue:
193, P. 112468 - 112468
Published: May 28, 2024
Aged
sarcopenia
is
characterized
by
loss
of
skeletal
muscle
mass
and
strength,
mitochondrial
dysregulation
in
myocyte
considered
as
a
major
factor.
Here,
we
aimed
to
analyze
the
effects
peroxisome
proliferator-activated
receptor
gamma
coactivator-1
alpha
(PGC-1α)
on
reactive
oxygen
species
(ROS)
nuclear
factor
erythroid
2-related
2
(Nrf2)
aged
muscles.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2021,
Volume and Issue:
21(1), P. 738 - 779
Published: Dec. 25, 2021
Abstract
Dietary
cholesterol
oxidation
products
(COPs)
are
heterogeneous
compounds
formed
during
the
processing
and
storage
of
cholesterol‐rich
foods,
such
as
seafood,
meat,
eggs,
dairy
products.
With
increased
intake
COPs‐rich
concern
about
health
implications
dietary
COPs
is
rising.
may
exert
deleterious
effects
on
human
to
induce
several
inflammatory
diseases
including
atherosclerosis,
neurodegenerative
diseases,
bowel
diseases.
Thus,
knowledge
regarding
conditions
leading
formation
needed
reduce
levels
in
foods.
Efficient
methodologies
determine
foods
also
essential.
More
importantly,
biological
roles
phytochemicals
COPs‐induced
need
be
established.
This
review
summarizes
recent
information
their
storage,
analytical
methods
determination
COPs,
metabolic
fate,
for
health,
beneficial
interventions
by
phytochemicals.
The
largely
dependent
heating
temperature,
time,
food
matrices.
Alteration
one
potent
strategies
restrict
hazardous
from
forming,
maintaining
relatively
low
temperatures,
shorter
or
appropriate
addition
antioxidants.
Once
absorbed
into
circulation,
can
contribute
progression
where
inflammation,
apoptosis,
autophagy
cells
target
organs
tissues.
Improved
an
effective
strategy
COPs.
