Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 379 - 400
Published: Dec. 1, 2023
Language: Английский
Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 77, P. 101615 - 101615
Published: March 27, 2022
Language: Английский
Citations
31
Journal of Lipid Research, Journal Year: 2023, Volume and Issue: 65(1), P. 100486 - 100486
Published: Dec. 16, 2023
Language: Английский
Citations
19
Cells, Journal Year: 2022, Volume and Issue: 11(8), P. 1251 - 1251
Published: April 7, 2022
Oxysterols are the products of cholesterol oxidation. They have a wide range effects on several cells, organs, and systems in body. also an influence physiology immune system, from cell maturation migration to innate humoral responses. In this regard, oxysterols been involved diseases that component, autoimmune neurodegenerative inflammatory diseases, atherosclerosis, cancer. Here, we review data participation oxysterols, mainly 25-hydroxycholesterol 7α,25-dihydroxycholesterol, system related diseases. The these main oxysterol receptors, LXR EBI2, cells (B T macrophages, dendritic oligodendrocytes, astrocytes), immune-related such as intestinal cancer, respiratory discussed.
Language: Английский
Citations
26
Steroids, Journal Year: 2022, Volume and Issue: 187, P. 109093 - 109093
Published: Aug. 24, 2022
Language: Английский
Citations
24
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2021, Volume and Issue: 21(1), P. 738 - 779
Published: Dec. 25, 2021
Abstract Dietary cholesterol oxidation products (COPs) are heterogeneous compounds formed during the processing and storage of cholesterol‐rich foods, such as seafood, meat, eggs, dairy products. With increased intake COPs‐rich concern about health implications dietary COPs is rising. may exert deleterious effects on human to induce several inflammatory diseases including atherosclerosis, neurodegenerative diseases, bowel diseases. Thus, knowledge regarding conditions leading formation needed reduce levels in foods. Efficient methodologies determine foods also essential. More importantly, biological roles phytochemicals COPs‐induced need be established. This review summarizes recent information their storage, analytical methods determination COPs, metabolic fate, for health, beneficial interventions by phytochemicals. The largely dependent heating temperature, time, food matrices. Alteration one potent strategies restrict hazardous from forming, maintaining relatively low temperatures, shorter or appropriate addition antioxidants. Once absorbed into circulation, can contribute progression where inflammation, apoptosis, autophagy cells target organs tissues. Improved an effective strategy COPs.
Language: Английский
Citations
30
Journal of Alzheimer s Disease, Journal Year: 2022, Volume and Issue: 87(4), P. 1527 - 1536
Published: April 29, 2022
Background: Brain cholesterol levels are tightly regulated but increasing evidence indicates that metabolism may drive Alzheimer’s disease (AD)-associated pathological changes. Recent advances in understanding of mitochondrial dysfunction AD brain have presented a vital role played by mitochondria oxysterol biosynthesis and their involvement pathophysiology. Oxysterol accumulation is controlled various enzymatic pathways including sulfation. While research into under the areas active investigation, there less for sulfate human brain. Objective: This study investigates hypothesis detoxification via sulfation impaired later stages resulting accumulation. Methods: Lipids were extracted from postmortem frozen tissue cerebrospinal (CSF) late- (Braak stage III-IV) early- I-II) patients. Samples spiked with internal standards prior to lipid extraction. Oxysterols enriched two-step solid phase extraction using polymeric SPE column further separation was achieved LC-MS/MS. Results: Oxysterols, 26-hydroxycholesterol (26-OHC), 25-hydroxycholesterol (25-OHC), 7-oxycholesterol higher late-stage except 24S-hydroxycholesterol, which decreased late AD. However, sulfates significantly lower frontal cortex. 25-OHC, 7-oxocholesterol CSF 26-OHC not changed. Conclusion: Our results show altered mitochondria, favoring synthesis 26-OHC, 7-oxocholesterol, this influence function acceleration disease.
Language: Английский
Citations
20
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
The proportion of the elderly population is gradually increasing as a result medical care advances, leading to subsequent surge in geriatric diseases that significantly impact quality life and pose substantial healthcare burden. Sarcopenia, characterized by age-related decline skeletal muscle mass quality, affects considerable portion older adults, particularly elderly, can adverse outcomes such frailty, fractures, bedridden, hospitalization, even mortality. Skeletal aging accompanied underlying metabolic changes. Therefore, elucidating these profiles specific mechanisms holds promise for informing prevention treatment strategies sarcopenia. This review provides comprehensive overview key metabolites identified current clinical studies on sarcopenia their potential pathophysiological alterations activity. Besides, we examine therapeutic from perspective focused regulation.
Language: Английский
Citations
4
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: Oct. 30, 2024
Autophagy is a molecular process essential for maintaining cellular homeostasis, with its impairment or dysregulation linked to the progression of various diseases in mammals. Specific lipids, including phosphoinositides, sphingolipids, and oxysterols, play pivotal roles inducing regulating autophagy, highlighting their significance this intricate process. This review focuses on critical involvement these lipids autophagy lipophagy, providing comprehensive overview current understanding functions. Moreover, we delve into how abnormalities influenced by contribute pathogenesis diseases. These include age-related conditions such as cardiovascular diseases, neurodegenerative disorders, type 2 diabetes, certain cancers, well inflammatory liver skeletal muscle pathologies macular degeneration (AMD). aims highlight function potential therapeutic targets treating diverse human elucidating specific oxysterols autophagy.
Language: Английский
Citations
4
Steroids, Journal Year: 2022, Volume and Issue: 183, P. 109032 - 109032
Published: April 4, 2022
Language: Английский
Citations
17
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12236 - 12236
Published: Oct. 13, 2022
Cholesterol and its oxidized forms, oxysterols, are ingested from foods synthesized de novo. oxysterols influence molecular cellular events subsequent biological responses of immune cells. The amount dietary cholesterol on the levels LDL blood plays a significant role in induction pro-inflammatory state cells, leading to inflammatory disorders, including cardiovascular disease. novo cells stroma involved homeostasis, which may also be influenced by an excess intake cholesterol. Dietary compounds such as β-glucan, plant sterols/stanols, omega-3 lipids, polyphenols, soy proteins, could lower interfering with absorption metabolism. Such have potential exert modulation through diverse mechanisms. This review addresses current knowledge about impact dietary-derived system. Possible immunomodulatory mechanisms elicited cholesterol-lowering discussed.
Language: Английский
Citations
17