Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 399, P. 111135 - 111135
Published: July 4, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 23, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling that mediate cytokine signals in mammals. Existing studies show the JAK/STAT pathway regulates downstream of numerous membrane proteins such as G-protein-associated receptors, integrins so on. Mounting evidence shows play an important role human disease pathology pharmacological mechanism. The are related aspects all immune system function, fighting infection, maintaining tolerance, strengthening barrier cancer prevention, which factors involved response. In addition, extracellular mechanistic might mediator influence progression, environment. Therefore, it is understand mechanism pathways, provides ideas for us design more drugs targeting diseases based on pathway. this review, we discuss signaling, environment, therapeutic targets.
Language: Английский
Citations
139
Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)
Published: Sept. 4, 2022
Abstract Osteoporotic fractures lead to increased disability and mortality in the elderly population. With rapid increase aging population around globe, more effective treatments for osteoporosis osteoporotic are urgently required. The underlying molecular mechanisms of believed be due activity osteoclasts, decreased osteoblasts, or both, which leads an imbalance bone remodeling process with accelerated resorption attenuated formation. Currently, available clinical have mostly focused on factors influencing remodeling; however, they their own limitations side effects. Recently, cytokine immunotherapy, gene therapy, stem cell therapy become new approaches treatment various diseases. This article reviews latest research mechanisms, as well how this underpins current potential novel osteoporosis.
Language: Английский
Citations
113
Bone Research, Journal Year: 2023, Volume and Issue: 11(1)
Published: March 1, 2023
Abstract Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid the biosynthesis compounds with antioxidant activities, glutathione. In past 10 years, increasing evidence has indicated potentially strong relationship between ferroptosis onset progression age-related orthopedic diseases, such as osteoporosis osteoarthritis. Therefore, in-depth knowledge regulatory mechanisms in diseases may help improve disease treatment prevention. This review provides an overview recent research on its influences bone cartilage homeostasis. begins brief systemic metabolism ferroptosis, particularly potential ferroptosis. presents discussion role promotion loss degradation inhibition osteogenesis. Finally, it focuses future targeting treat intention inspiring further clinical development therapeutic strategies.
Language: Английский
Citations
95
Animals, Journal Year: 2022, Volume and Issue: 12(15), P. 1946 - 1946
Published: July 31, 2022
As an essential component of the skeleton, bone tissue provides solid support for body and protects vital organs. Bone is a reservoir calcium, phosphate, other ions that can be released or stored in controlled manner to provide constant concentration fluids. Normally, development osteogenesis occurs through two ossification processes (intra-articular intra-chondral), but first produces woven bone, which quickly replaced by stronger lamellar bone. Contrary commonly held misconceptions, relatively dynamic organ undergoes significant turnover compared organs body. metabolism process involves simultaneous formation resorption, numerous factors. comprises key actions. Skeletal mass, structure, quality are accrued maintained throughout life, anabolic catabolic actions mostly balanced due tight regulation activity osteoblasts osteoclasts. This also provided circulating hormones cytokines. remodeling regulated various biologically active substances secreted cells, namely RANK, RANKL, MMP-1, MMP-9, type 1 collagen. Bone-derived factors (BDF) influence function metabolism, pathophysiological conditions lead dysfunction. work aims analyze evaluate current literature on local systemic immune system interactions affect its impairments.
Language: Английский
Citations
73
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 12, 2025
Senescent mandibular bone repair poses a formidable challenge without completely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages in regeneration, disruptions these processes present significant obstacles to senescent repair. To address issues, engineered extracellular vesicles (EV) with stem functions were developed. This study demonstrated that Apt19s-engineered (Apt19s-EV) recognize recruit marrow mesenchymal cells derived from old rats (O-BMSCs) specifically effectively. MiR-376b-5p, identified by RNA sequencing transfection, was significantly decreased O-BMSCs, it selected construct miR-376b-5p-engineered (376b-EV). 376b-EV could promote osteogenesis alleviate senescence of O-BMSCs targeting Camsap1. combine the advantages Apt19s miR-376b-5p, dual (Apt-376b-EV) comprising both miR-376b-5p modifications constructed. further validate its function, Gelatin methacryloyl (GelMA) hydrogel used as carrier Apt-376b-EV@GelMA delivery system. The vitro results have sequentially. Notably, vivo also showed sequentially endogenous enhance new formation fracture critical-sized defect models. In summary, vesicles, Apt-376b-EV, offer an appealing solution for recruiting promoting microenvironment, which may broaden clinical applications EV provide valuable strategies treating bone-related diseases future work.
Language: Английский
Citations
2
Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)
Published: Oct. 27, 2023
Abstract The musculoskeletal system supports the movement of entire body and provides blood production while acting as an endocrine organ. With aging, balance bone homeostasis is disrupted, leading to loss degenerative diseases, such osteoporosis, osteoarthritis, intervertebral disc degeneration. Skeletal diseases have a profound impact on motor cognitive abilities elderly, thus creating major challenge for both global health economy. Cellular senescence caused by various genotoxic stressors results in permanent cell cycle arrest, which considered be underlying mechanism aging. During senescent cells (SnCs) tend aggregate trigger chronic inflammation releasing senescence-associated secretory phenotypic factors. Multiple signalling pathways are involved regulating cellular marrow microenvironments. Targeted SnCs alleviate age-related diseases. However, association between remains unclear. This review summarises fundamental role skeletal highlights that mediate senescence, discusses potential therapeutic strategies targeting SnCs. Graphical
Language: Английский
Citations
34
Bioengineering, Journal Year: 2023, Volume and Issue: 10(1), P. 85 - 85
Published: Jan. 9, 2023
Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor macrophages, osteoblasts and -clasts, chondrocytes to restore the osseous tissue. Particularly in long bones including tibia, clavicle, humerus femur, this fails 2-10% of all fractures, with devastating effects for patient healthcare system. Underlying reasons failure are manifold, from lack biomechanical stability impaired biological host conditions wound-immanent intricacies. In review, we describe cellular components involved bone how they interfere delicately orchestrated processes repair formation. We subsequently outline weigh risk factors development non-unions that have been established literature. Therapeutic prospects illustrated put into clinical perspective, before applicability biomarkers finally discussed.
Language: Английский
Citations
26
Bone Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Aug. 5, 2024
Abstract Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including skeletal immune systems. Recent studies have elucidated intricate bidirectional interactions between these two In this review, we provide comprehensive synthesis molecular mechanisms cell ageing. We further discuss how age-related changes influence system consequent impact alterations on system. Finally, highlight clinical implications findings propose potential strategies to promote healthy ageing reduce pathologic both
Language: Английский
Citations
13
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: March 27, 2024
Abstract Senile osteoporosis is mainly caused by osteoblasts attenuation, which results in reduced bone mass and disrupted remodeling. Numerous studies have focused on the regulatory role of m6A modification osteoporosis; however, most investigated differentiation marrow mesenchymal stem cells (BMSCs), while direct mechanism remains unknown. This study revealed that progression senile closely related to downregulation methyltransferase-like 3 (METTL3). Overexpression METTL3 inhibits osteoblast aging. Methylated RNA immunoprecipitation sequencing (MeRIP-seq) upregulates stability Hspa1a mRNA, thereby inhibiting Moreover, demonstrated enhances mRNA via regulate Notably, YTH N6-methyladenosine binding protein 2 (YTHDF2) participates stabilizing METTL3-mediated process, rather than well-known degradation function. Mechanistically, increases a YTHDF2-dependent manner inhibit Our confirmed significant aging suggested could be potential therapeutic target for osteoporosis.
Language: Английский
Citations
10
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: March 21, 2024
Introduction Osteoporosis, a disease of reduced bone mass and microstructural deterioration leading to fragility fractures, is becoming more prevalent as aging progresses, significantly increasing the socioeconomic burden. In past studies, there has been growing awareness harmful effects heavy metals on bone, with cadmium being significant exposure factor. The purpose this study was look into association between adult mineral density(BMD) blood levels. Methods Based information from 2013–2014, 2017–2018 NHANES, weighted multiple regression, generalized modeling, smoothed curve fitting were utilized investigate femur BMD. Furthermore, subgroup analyses conducted any differences in associations age, sex, race, chronic kidney disease, diabetes. Results 2,146 participants, levels total [-0.02 (-0.03, -0.01), 0.0027], femoral neck [-0.01 (-0.02, -0.00), 0.0240], trochanter 0.0042], intertrochanteric 0.0101] BMD negatively correlated. Subgroup showed that pronounced women, non-Hispanic white people other Hispanics, those Our results pointed negative relationship cadmium. This varied by diabetes, disease. particular, density affected groups diabetes Conclusion findings demonstrated population U.S. adults.
Language: Английский
Citations
9