Extranodal Rosai-Dorfman Disease Manifesting as Sjögren’s Syndrome Combined with Panuveitis and Hypertrophic Pachymeningitis: A Case Report and Review of Literature DOI Creative Commons
Jing Xu,

Meihua Huang,

Binsong Dong

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 31, 2023

Abstract Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions. Case presentation: We present case of 28-year-old female who presented with recurrent blurred vision in her right eye for 3 months. Her left had been blinded atrophied decade prior. She subsequently developed headache, fever, impaired mental status. Cranial MRI indicated hypertrophic pachymeningitis (HP), 18 F-FDG PET/CT revealed significant FDG uptake the dura mater. Autoimmune testing elevated anti-nuclear, anti-SS-A, anti-SS-B antibodies. Incisional biopsy atrophic eyeball RDD marked polyclonal plasmacytosis. The patient was diagnosed accompanied multisystem involvement, including Sjögren’s syndrome (SS), panuveitis, HP. Treatment methylprednisolone over several weeks resulted improvement. Conclusions: This first reported presenting SS combination panuveitis Although rarely young patients, interdisciplinary collaboration essential to prevent delayed diagnosis.

Language: Английский

Surface-Charge-Driven Ferroptosis and Mitochondrial Dysfunction Is Involved in Toxicity Diversity in the Marine Bivalve Exposed to Nanoplastics DOI
Yanfei Zhou, Wenzhi Liu, Hao Jiang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2370 - 2383

Published: Jan. 8, 2024

Nanoplastics (NPs) pervade daily life, posing serious threats to marine ecosystems. Despite the crucial role that surface charge plays in NP effects, there is a substantial gap our understanding of how influences toxicity. Herein, by exposing

Language: Английский

Citations

13
CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis DOI Creative Commons

Jiannan Zhou,

Janak L. Pathak,

Tingting Cao

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(4), P. 167121 - 167121

Published: March 11, 2024

Language: Английский

Citations

8
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis DOI

Jiannan Zhou,

Janak L. Pathak, Lihong Wu

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 218, P. 1 - 15

Published: April 2, 2024

Language: Английский

Citations

6
Paeoniflorin alleviated experimental Sjögren's syndrome by inhibiting NLRP3 inflammasome activation of submandibular gland cells via activating Nrf2/HO-1 pathway DOI
Tingting Jiang, Xuanqi Liu, Shumin Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sjögren’s syndrome DOI Creative Commons
Fengtao Pang, Quan Jiang, Xiaopo Tang

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Language: Английский

Citations

0
AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein DOI Creative Commons
Claudia D’Agostino, Egor Zindy,

Louise Conrard

et al.

Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 16, 2025

Abstract Background Aquaporin-5 (AQP5) is a crucial membrane protein involved in water transport across cellular membranes, particularly within exocrine glands such as salivary glands. Dysregulation of AQP5, including its mislocalization, has been associated with various diseases, emphasizing the need to understand molecular mechanisms governing trafficking. This study investigates multifaceted regulatory AQP5 trafficking, specific emphasis on role carboxyl-terminal (C-terminal) tail and functional involvement prolactin-inducible (PIP) an interacting partner. Methods An innovative 2D-custom model employing SNAP-tag human constructs together novel automated algorithm-based methodology was used following immunofluorescence confocal microscopy assess hAQP5 localization plasma stably transfected normal gland-SV40 transformed-acinar cells (NS-SV-AC). The expression verified by Western blot analysis. Results SNAP-hAQP5 expressed NS-SV-AC allowed explore C-terminal hAQP5-hPIP interaction trafficking upon stimulation. use truncation revealed distinct responses intracellular 3’,5’-cyclic adenosine monophosphate (cAMP) calcium increase, shedding light importance regions highly flexible distal part for Furthermore, our investigation interplay between hPIP that PIP promotes translocation membrane, blunting effects calcium- cAMP-dependent pathways sub-cellular localization. Conclusion In summary, this advances understanding dynamics provides critical insights into roles PIP. sets stage future investigations identify individual amino acids phosphorylation sites C-terminus mechanism protein-protein interaction, dynamic process high resolution live cell imaging. Further research area warranted uncover regulation offering opportunities development therapeutic strategies.

Language: Английский

Citations

0
Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress DOI Open Access
Jimin Yoon, Doyeong Ku, Min-Seok Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7403 - 7403

Published: April 17, 2023

Human mitochondria contain a circular genome that encodes 13 subunits of the oxidative phosphorylation system. In addition to their role as powerhouses cells, are also involved in innate immunity mitochondrial generates long double-stranded RNAs (dsRNAs) can activate dsRNA-sensing pattern recognition receptors. Recent evidence shows these dsRNAs (mt-dsRNAs) closely associated with pathogenesis human diseases accompany inflammation and aberrant immune activation, such Huntington’s disease, osteoarthritis, autoimmune Sjögren’s syndrome. Yet, small chemicals protect cells from mt-dsRNA-mediated response remain largely unexplored. Here, we investigate potential resveratrol (RES), plant-derived polyphenol antioxidant properties, on suppressing activation. We show RES revert downstream immunogenic stressors elevate RNA expressions, stimulation by exogenous or inhibition ATP synthase. Through high-throughput sequencing, find regulate mt-dsRNA expression, interferon response, other cellular responses induced stressors. Notably, treatment fails counter effect an endoplasmic reticulum stressor does not affect expression RNAs. Overall, our study demonstrates usage alleviate stress response.

Language: Английский

Citations

5
Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice DOI Creative Commons
Ying Bai, Guohu Di, Huanhuan Ge

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2023, Volume and Issue: 64(12), P. 27 - 27

Published: Sept. 14, 2023

Dry eye disease (DED) is multifactorial and associated with nerve abnormalities. We explored an Aquaporin 5 (AQP5)-deficiency-induced JunB activation mechanism, which causes abnormal lacrimal gland (LG) distribution through Slit2 upregulation Netrin-1 repression.Aqp5 knockout (Aqp5-/-) wild-type (Aqp5+/+) mice were studied. LGs permeabilized stained neuronal class III β-tubulin, tyrosine hydroxylase (TH), vasoactive intestinal peptide (VIP), calcitonin gene-related (CGRP). Whole-mount images acquired tissue clearing 3D fluorescence imaging. Mouse primary trigeminal ganglion (TG) neurons treated LG extracts Netrin-1/Slit2 neutralizing antibody. Transcription factor (TF) prediction chromatin immunoprecipitation-polymerase chain reaction (ChIP-PCR) experiments verified the binding regulatory effect on Slit2.Three-dimensional section immunofluorescence showed reduced nerves in Aqp5-/- mice, sympathetic sensory significantly decreased. was increased LGs. Aqp5+/+ (TEs) promoted TG axon growth, but antibody (NAb) could inhibit that promotion. TEs inhibited NAb alleviated inhibition. Furthermore, JunB, a TF, bind them regulate their expression. SR11302, meanwhile, reversed shifts caused by AQP5 deficiency.AQP5 deficiency Persistent activation, common denominator for suppression induction, found epithelial cells. This affected fibers' Our findings provide insights into preventing, reversing, treating DED.

Language: Английский

Citations

4
Aquaporins in lacrimal glands and their role in dry eye disease DOI
Ying Bai, Kaier Zhang, Xin Cao

et al.

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 236, P. 109676 - 109676

Published: Oct. 10, 2023

Language: Английский

Citations

4
The Role of Aquaporin 4 in Lacrimal Gland Ductal Fluid Secretion in Mice DOI Creative Commons

Gréta Elekes,

Virág Csapó,

Dóra Szarka

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(5), P. 30 - 30

Published: May 21, 2024

Purpose: Earlier reports highlighted the predominant presence of aquaporin 4 (AQP4) in duct cells rabbit lacrimal glands (LGs). Whereas significant alterations AQP4 mRNA levels have been observed experimental dry eye and during pregnancy, impact LG ductal fluid production remains unclear. In our recent work, role secretion was investigated utilizing wild type (WT) knock out (KO) mice. Methods: Tear assessed both WT KO animals. Immunostaining used to identify protein. Duct segments were harvested from LGs Fluid filtration permeability (Pf) quantified using video-microscopy. Ductal tear production, elicited by a cell-permeable cAMP analogue (8-bromo cAMP), carbachol, vasoactive intestinal peptide (VIP), phenylephrine (PHE), ducts. Results: A higher expression protein noted mice when compared acinar cells. Pf did not show notable between Carbachol comparable secretory responses ducts However, 8-bromo cAMP, VIP, PHE stimulation resulted decreased LGs. Conclusions: Our findings underscore functional relevance mouse seems play different roles secretions secretagogues. Specifically, cAMP-mediated, adrenergic agonist-related reduced

Language: Английский

Citations

1