British Journal of Haematology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 7, 2024
There
has
been
an
expansion
in
our
understanding
of
the
multifaceted
roles
circulating
blood
cells
regulating
haemostasis
and
contributing
to
thrombosis.
Notably,
there
is
greater
recognition
interplay
between
coagulation
with
inflammation
innate
immune
activation
contribution
leucocytes.
The
full
count
(FBC)
a
time-honoured
test
medicine;
however,
its
components
are
often
viewed
isolation
without
consideration
their
haemostatic
thrombotic
potential.
Here,
we
review
how
individual
FBC,
that
is,
haemoglobin,
platelets
leucocytes,
engage
system
focus
on
both
quantitative
qualitative
attributes.
We
also
explore
this
information
can
be
harnessed
into
better
management
people
multiple
long-term
conditions
because
higher
risk
adverse
clinical
events.
Arteriosclerosis Thrombosis and Vascular Biology,
Journal Year:
2023,
Volume and Issue:
43(8), P. 1349 - 1361
Published: June 15, 2023
Independent
of
etiology,
hemolytic
diseases
are
associated
with
thrombosis,
inflammation
and
immune
dysregulation,
all
together
contributing
to
organ
damage
poor
outcome.
Beyond
anemia
the
loss
anti-inflammatory
functions
red
blood
cells,
hemolysis
leads
release
damage-associated
molecular
patterns
including
ADP,
hemoglobin,
heme,
which
act
through
multiple
receptors
signaling
pathways
fostering
a
hyperinflammatory
hypercoagulable
state.
Extracellular
free
heme
is
promiscuous
alarmin
capable
triggering
oxido-inflammatory
thrombotic
events
by
inducing
activation
platelets,
endothelial
innate
cells
as
well
coagulation
complement
cascades.
In
this
review,
we
discuss
main
mechanisms
and,
in
particular,
drive
thrombo-inflammatory
milieu
consequences
on
host
response
secondary
infections.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(4)
Published: April 27, 2024
Abstract
Mitochondria
are
the
centers
of
energy
and
material
metabolism,
they
also
serve
as
storage
dispatch
hubs
metal
ions.
Damage
to
mitochondrial
structure
function
can
cause
abnormal
levels
distribution
ions,
leading
cell
dysfunction
even
death.
For
a
long
time,
quality
control
pathways
such
dynamics
mitophagy
have
been
considered
inhibit
metal-induced
However,
with
discovery
new
metal-dependent
death
including
ferroptosis
cuproptosis,
increasing
evidence
shows
that
there
is
complex
relationship
between
This
article
reviews
latest
research
results
mechanisms
crosstalk
in
recent
years,
well
their
involvement
neurodegenerative
diseases,
tumors
other
order
provide
ideas
for
treatment
related
diseases.
Journal of Thrombosis and Haemostasis,
Journal Year:
2024,
Volume and Issue:
22(8), P. 2140 - 2146
Published: May 28, 2024
It
is
increasingly
apparent
that
the
pathologic
interplay
between
coagulation
and
innate
immunity,
ie,
immunothrombosis,
forms
common
basis
of
many
challenges
across
boundaries
specialized
medicine
cannot
be
fully
explained
by
conventional
concepts
cascade
cell-based
coagulation.
To
improve
our
understanding
coagulation,
we
propose
a
model
converges
with
inflammation
immune
activation
as
unified
response
toward
vascular
injury.
Evolutionarily
integral
to
convergent
are
damage-associated
molecular
patterns,
which
released
consequence
Damage-associated
patterns
facilitate
diverse
interactions
within
systems,
not
only
complement
reinforce
clot
formation
but
also
steer
resolution
wound
healing.
By
extending
beyond
its
current
boundaries,
aims
deliver
novel
diagnostics
therapeutics
for
contemporary
unexpected
medicine,
exposed
COVID-19
vaccine-induced
thrombotic
thrombocytopenia.
International Wound Journal,
Journal Year:
2023,
Volume and Issue:
20(9), P. 3840 - 3854
Published: May 17, 2023
Abstract
Wound
healing
is
an
extremely
complex
process
involving
multiple
levels
of
cells
and
tissues.
It
mainly
completed
through
four
stages:
haemostasis,
inflammation,
proliferation,
remodelling.
When
any
one
these
stages
impaired,
it
may
lead
to
delayed
or
even
transformation
into
chronic
refractory
wounds.
Diabetes
a
kind
common
metabolic
disease
that
affects
approximately
500
million
people
worldwide,
25%
whom
develop
skin
ulcers
break
down
repeatedly
are
difficult
heal,
making
growing
public
health
problem.
Neutrophils
extracellular
traps
ferroptosis
new
types
programmed
cell
death
identified
in
recent
years
have
been
found
interact
with
diabetic
In
this
paper,
the
normal
wound
interfering
factors
were
outlined.
The
mechanism
two
kinds
was
also
described,
interaction
between
different
wounds
discussed.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6243 - 6243
Published: March 26, 2023
Proteostasis,
i.e.,
the
homeostasis
of
proteins,
responsible
for
ensuring
protein
turnover,
is
regulated
by
proteases,
which
also
participate
in
etiopathogenesis
multiple
conditions.
The
magic
proteases
such
that,
blood
coagulation,
one
same
molecule,
as
coagulation
factor
V,
example,
can
perform
both
a
procoagulant
and
an
anticoagulant
function
result
activity
proteases.
However,
this
has
insidious
side
to
it,
it
may
prevent
completion
clinical
value
chain
V
deficiency.
This
encompasses
discovery
knowledge,
transfer
its
translation
practice.
In
case
rare
ultra-rare
diseases
like
deficiency,
not
been
completed
knowledge
acquisition
phase
dragged
out
over
time,
holding
up
reason
related
small
number
patients
afflicted
with
these
As
result,
new
indications
must
be
found
make
therapies
cost-effective.
significant
research
efforts
have
directed
at
developing
recombinant
capable
resisting
action
inactivating
factor.
where
bioethics
health
equity
considerations
come
into
equation.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Iron
metabolism
of
neutrophils
plays
a
vital
role
in
neutrophil
extracellular
trap
(NET)
formation,
which
presents
as
one
the
major
hurdles
to
immune
response
tumor
microenvironment.
Here,
we
developed
peptide-drug
conjugate
(PDC)-based
transformable
iron
nanochelator
(TIN)
equipped
with
ability
regulate
neutrophils,
endowing
inhibition
NET
formation
and
ensuing
immunosuppression
functions.
The
TIN
could
expose
iron-binding
motifs
through
elastase-mediated
morphological
transformation
from
nanoparticles
β-sheet
nanofibers,
further
evolve
into
stable
α-helix
nanofibers
after
chelation
iron(II)
ions.
This
process
enables
highly
specific
regulation
ions
turns
an
efficient
way
inhibiting
improving
response.
Furthermore,
showed
improved
therapeutic
effect
combination
protein
arginine
deiminase
4
inhibitors
synergistically
boosted
anti-PD-L1
treatment.
study
designates
iron-regulation
strategy
inhibit
provides
alternative
approach
modulation
perspective
targeting
cancer
immunotherapy.
